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MeSH term: ... Disease relevance of Autophagy Here, we show that Runx1 is required to sustain muscle by preventing denervated myofibers from undergoing myofibrillar disorganization and autophagy, structural defects found in a variety of congenital myopathies. The beclin 1 autophagy gene is monoallelically deleted in 40- 75... / Synonyms: Autophagy, Cellular; Cellular Autophagy
Homo sapiens
Gene: ... . Recent studies examining cells lacking the autophagy genes Atg5 and Atg7 have demonstrated that autophagy... dramatically increased cell death. A critical role for the autophagy gene Atg5 in T cell survival...) to phosphatidylethanolamine( PE) and ATG12 to ATG5, are biochemical hallmarks for autophagy, a cellular process that degrades... / Synonyms: Autophagy protein 5
Homo sapiens
Gene: ... that all of them predominantly distributed to the plasma membrane and the endoplasmic reticulum. In contrast to findings in yeast, induction of autophagy by Atg1 is dependent on its kinase activity... and demonstrate that autophagy has the capacity to induce cell death. Direct induction of autophagy by atg1... / Synonyms: Autophagy-related protein 1 homolog
Mus musculus
Gene: ... High impact information on Atg5 A critical role for the autophagy gene Atg5 in T cell survival... and function and suggest that autophagy may be essential for both T lymphocyte survival and proliferation... examining cells lacking the autophagy genes Atg5 and Atg7 have demonstrated that autophagy plays essential... / Synonyms: Autophagy protein 5
Drosophila melanogaster
Gene: ... High impact information on Atg6 Atg6/ Beclin 1 is thought to function as a VPS and autophagy protein as part of a complex with Class III phosphatidylinositol 3 '- kinase( PI3K )/ Vps34.... / Synonyms: Autophagy protein 6-like
Homo sapiens
Gene: ... with autophagy and tumor suppressor function and is monoallelically deleted in 40- 75% of sporadic human breast... cells that express Env induced autophagy and accumulation of Beclin 1 in uninfected CD4+ T lymphocytes... feature of autophagy, and siRNA- mediated downregulation of the beclin- 1 gene, whose product is crucial...
Homo sapiens
Gene: ... High impact information on ATG10 We further show that two hydrophobic residues within the ubiquitin- fold region are important for autophagy: mutation at Y149 affects conjugate formation catalyzed by Atg... but its hydrophobic nature is essential for autophagy.... / Synonyms: Autophagy-related protein 10
Homo sapiens
Gene: ... , and execution of autophagy.... / Synonyms: Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B
Arabidopsis thaliana
Gene: ... autophagy in Arabidopsis seedlings in an AtATG18a- dependent manner and that RNAi- AtATG18a transgenic lines... / Synonyms: autophagy 18a
Homo sapiens
Gene: ... of the yeast Apg12p conjugation system essential for autophagy. The Apg12- Apg5 conjugate localizes.... Structure- Function Relationship of Atg12, a Ubiquitin- like Modifier Essential for Autophagy. Biological... for autophagy, a cellular process that degrades bulk cellular proteins and organelles. Atg12, a post... / Synonyms: Autophagy-related protein 12
Links to contributing authors:
Steven Johnsen and Donald R. Forsdyke and Kehinde Ross and Andrew Perry and Jonathan Eisen and A. Shimabukuro-Vornhagen and Giuseppe Rotondo and Gordon Laurie and Berkley Lynch and Kung-Hao Liang and Matthias Gstaiger and Thomas Pfeiffer and Marta Ramirez and Grant MacGregor and Jingyu Li and Fedik Rahimov and M El Gizouli and Marta Ramirez Gaite and Oswaldo Ribeiro-filho and Ralf Weigel and Bjoern Hamberger and Alexander Kanitz and Andreas Zankl and Chunming Ding and Maruf Yunus and Jonathan S. Berg and Michael Cariaso and Zakir Thomas and Monique Timberlake-Brady and LC Dore and Nan Shen and R. Eric Collins and Kuang-Mao Chiang and Brendan McMahon and John Chew and Wen-Ming Yang and Robert Hoffmann and J.B. Stewart and Manuela Cucerea and Ignacio García and William James and Thomas Kelder and Gregory Melahn and YINGDE ZHU and Andres Muro and Gabriel Santpere and Jeff Freilich and Junbin Qian and Steffen Poulsen and Eric Villard and Rafael Sidi and Grant Cramer and Chris Sander and Alexandre Chigaev and Florian Uhle and Carl Fulp and Andrew Brown and Xiaozhu Zhou and Corina Dutu and Hilary Spencer and david germano and Abbas Dehghan and Eung-ju PARK and Chris Sander and Albert Vilella and Miao Tian and Anjali Bheda and Michael Nevels and Jun Liu and D Delano and Chitose Taya and Soomi Cheong and David Kavanagh and Maha Karnoub and Hilmar Lapp and Christian Pallasch and Daniel Mietchen and Biju Balakrishnan and Keith Ashman and Juan Carlos Sobrino and Anshu Bhardwaj and Grzegorz Wickiel and Matthew Day and Anthony Sebastian and Vedran Katavic and Liang Long and Barry Wanner and Sarah Snelling and Fernando Montanes and Omobosede Fashedemi and Gustavo Cervantes and Manoj Kumar and Edward D Great and Paul Paukstelis and Roy Soetikno and Ana I Caño-Delgado and Minsoo Choi and Lei Wang and Brenda Riley and A Michelle Moon and Jon Moulton and Mahmoud Elshahawy and Meagan Gillespie and Banundari Rachmawati and Qian Han and Eric Danner and Xavier Fouillet and Madhusudhan Acharya and Brian Young and Chandra Sekhar Mukhopadhyay and shrawan bhattacharjee and Marieke van der Linden and cj hoban and Sandi Pniauskas and jackie gao and Metin Bilgin and Gillian L. Dalgliesh and Karl Wotton and Iveta Herichova and Yuji Morita and Marta Hernandez and Gregor Krings and Marco Briones and Tim D. Smith and Yiumo Michael Chan and Zhenyu Guo and Barry Barclay and Hong Wang and tarali chowdhury and Tilman Brummer and Nuno Faria and Tamir Ben David and Myles Axton and Yannick Fonseca and Francis Castets and Modesto Redrejo-Rodríguez and Bruce Herron and Toshio Fujita and Elena Puccetti and Zhang Zhang and John Osborne and Illes J Farkas and Fernando Andres and Phyllis Pugh and Jonathan Court and Tim Vickers and Nir Friedman and Holger Dick and Ya-Chen Liang and Jonathan Froehlich and Haitham Sobhy and David Abraham and Stephane Krief and Yaroslav Nikolaev and Qiping Feng and d gupta and R Thapar and Susan Wee and Michael Rehman and SOUMITRA GHOSH and Mohamed Eweida and Cedric Uytingco and Nie hongchuan and David Steenblock and Mark A. Kukucka and Zoli Fekete and Sergei Kozlov and Javier Jara and Osama Naguib and Felix Benninger and jean-marc lo-guidice and VASUDEVA BHAT and Anne O. Summers and Bjoern Titz and Anna Levine and Klas Udekwu and Robert Hoffmann
