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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 109 documents. Results 1 - 10.

Homo sapiens
Gene: ... efficiently metabolized by both NAT1 and NAT2. In addition, all case patients and matched control subjects...Disease relevance of NAT2 While evidence from this study cannot be conclusive, our data suggest that NAT1 and NAT2 variants may explain an approximately twofold increase in polyp number in the FAP colon... / Synonyms: NAT-2
NAT2  -  Nat2p
Saccharomyces cerevisiae S288c
Gene: ... High impact information on NAT2 We propose that NAT2 encodes the major N alpha- acetyl- transferase... of these proteins is essential for viability. NAT2, an essential gene encoding methionine N alpha- acetyltransferase in the yeast Saccharomyces cerevisiae. The NAT2 wild- type gene was cloned by complementation of the nat2- 1...
Mus musculus
Gene: ... Disease relevance of Nat2 The Nat2 promoter consists of an atypical TATA box and a Sp1[ SV40... effect on endogenous Nat2 mRNA levels. Two genes( NAT1, NAT2) have been identified and allelic variation in NAT2 has been associated with arylamine toxicity in adults. To investigate the role of prostate... / Synonyms: NAT-2
Rattus norvegicus
Gene: ... Disease relevance of Nat2 We previously reported an association between the N- acetyltransferase 2( NAT2) slow acetylator status and Parkinson' s disease( PD). The cardioprotective effects... for the 290 amino acid, 33- 34 kDa cytosolic acetyltransferases( NAT1* and NAT2 *) from rat and hamster were... / Synonyms: NAT-2
Homo sapiens
Gene: ... and/ or NAT2 loci. Beginning in January 1992, all case patients and their matched control subjects... evidence from this study cannot be conclusive, our data suggest that NAT1 and NAT2 variants may explain... higher mutagenic activity in Salmonella strains expressing human NAT1 and human NAT2, respectively, than...
MeSH term: ... statistically significant. Linear regression analysis found no association between NAT2 activity and the levels... myocardial norepinephrine depletion and left ventricular dysfunction, which was independent of all other... analyses revealed that plasma triglyceride concentrations in all fed, treated rats correlated significantly...
MeSH term: ... carcinogen metabolites by polymorphic N- acetyltransferase( NAT2) in colon tissues. This suggests... to Disease Examination of the prion protein genes of all these cases and of a single case of gonadotropin...
MeSH term: ... in the antiproliferative response of mesothelioma cell lines. Inherited GSTM1 and NAT2 defects as concurrent risk modifiers... mesothelioma and may result in the loss of p14( ARF) and the inactivation of p53. All malignant mesothelioma...
MeSH term: ... at the NAT2 gene locus. We quantitatively compared the cell- transforming activity of BP- A and 4 of its... expression. Prostate expression of N- acetyltransferase 1( NAT1) and 2( NAT2) in rapid and slow acetylator...
MeSH term: ... is expressed in the urothelium and may O- acetylate hydroxyl amines, particularly in subjects with low NAT2... and, in all cases, a strong distinct staining of invasive tumor areas and metastatic secondary tumors...

 

 
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