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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 104 documents. Results 1 - 10.

Homo sapiens
Gene: ... Disease relevance of PF4 Pertussis toxin did not block the PF4- derived IL- 8 production in NK...- kinase in the intracellular signaling pathway triggered by PF4. Plasma levels of PF4, beta TG, TAT, FPA... %) and PF4 was found in eight( 21. 6 %). The effect of human platelet factor 4( PF4) and beta... / Synonyms: PF-4
Mus musculus
Gene: ... propose that the main biological role of PF4 and the basis for its presence in the alpha granules of all...Disease relevance of Cxcl4 These studies support an important role for PF4 in thrombosis, and show that neutralization of PF4 is an important component of heparin' s anticoagulant effect. Our results suggested... / Synonyms: PF-4
Rattus norvegicus
Gene: ... and is not neutralised by PF4. High impact information on Cxcl4 The subdomain from- 380 to- 362 is most critical in restricting gene expression driven either by the PF4 promoter or by a heterologous promoter... enhancer/ silencer domain and the GATA site are responsible for high- level expression of the PF4 gene... / Synonyms: PF-4; Pf4a
Homo sapiens
Gene: ... that were all conserved among human, bovine, and rat PF4s. Other interactions of PF4V1 Here, the product...Disease relevance of PF4V1 Thus, activated platelets release CXCL4L1, a potent regulator of endothelial cell biology, which affects angiogenesis and vascular diseases. High impact information on PF4V1... / Synonyms: PF4-ALT; PF4A; PF4alt
Chemical compound: ... may be due in part to requirements for specific biophysical parameters of the PF4/ heparin complexes that occur in settings of intense platelet activation and PF4 release. Mutations that affect the heparin...
Bos taurus
Gene: ... of the heparin binding protein, bovine platelet factor 4. At 37 degrees C, PF- 4 was internalized by confluent... library demonstrated the existence of a variant of platelet factor 4, designated PF4var1. A short peptide... line. To examine the interactions of PF- 4 with the GAGs present on endothelial cell surfaces, we...
Chemical compound: ... malignancies. All 11 patients with elevated urinary PF4 excretion exhibited myelofibrosis, whereas 11 of 22... potential genetic regulatory regions for PF4var1. All 19 samples with a positive platelet aggregation test...Disease relevance of tetrafluorophosphanium Since anti- H/ PF4 Abs are mainly IgG1 and IgG3... / Synonyms: PF4+; PF4(+); [PF4](+)
MeSH term: ... mitogenesis; this activity coeluted with PF 4 upon gel filtration, heparin- agarose, and ion- exchange... normal mice, all of it intact by gel exclusion chromatography. The gamma- aminobutyric acid binding... was fractionated to identify the factor that corrects all the abnormalities in Williams trait plasma, the Williams...
Homo sapiens
Gene: ... thrombosis during heparin treatment, which is not statistically different from the patients with H- PF4... and H- PF4 autoantibodies( n= 72 ), patients with autoimmune diseases( n= 21 ), or patients with non... compound and disease context of PPBP The mean values of the plasma BTG, PF4, and 5- HT concentrations... / Synonyms: LA-PF4
MeSH term: ... library demonstrated the existence of a variant of platelet factor 4, designated PF4var1. Due...

 

 
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