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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 23 documents. Results 1 - 10.

Mus musculus
Gene: ... Disease relevance of Ptf1a Mutations in the human and mouse PTF1A/ Ptf1a genes result in permanent diabetes mellitus and cerebellar agenesis. Inactivation of Ptf1a leads to a fate- switch in these precursors that causes them to adopt a ganglion cell fate. High impact information on Ptf1a These experiments...
Danio rerio
Gene: ... High impact information on ptf1a Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Within the endoderm, ptf1a is initially expressed at 32 hpf in the ventral portion of the pdx1 expression domain; ptf1a is expressed in a subset of cells located on the left...
Homo sapiens
Gene: ... High impact information on PTF1A Reporter- gene studies using a minimal PTF1A deletion mutant indicate that the deleted region defines a new domain that is crucial for the function of this protein. PTF1A is known to have a role in mammalian pancreatic development, and the clinical phenotype...
Rattus norvegicus
Gene: ... High impact information on Ptf1a The ptf1- p48 gene measures 1. 8 kilobases in size and occurs as a single copy in the haploid genome. The ability of Hes1 to interact with Ptf1- p48 resides within...[ also known as Ptf1a( pancreas specific transcription factor 1a )], and a class I E- box binding partner....
MeSH term: ... signals to form mesoderm and endoderm. These experiments provide evidence that Ptf1a expression... in embryogenesis causes all non- endodermal lineages to produce endoderm instead of ectoderm and/ or mesoderm. High...
MeSH term: ... information on Pancreatic Ducts We used recombination- based lineage tracing in vivo to show that Ptf1a( also... with pancreatic ducts. Large T- antigen immunoreactivity was detected in all the nuclei of neoplastic cells...
MeSH term: ... - gene studies using a minimal PTF1A deletion mutant indicate that the deleted region defines a new...
Canis lupus familiaris
Gene

 

 
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