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Herpes simplex: Host viral protein interactions.




A database of HSV-1 interacting host proteins: Genes refer to Homo sapiens : Only direct interactions are reported. If inserting a line, do so from the line below the point of insertion, otherwise the new line will be in bold.Current direct interactions ~ 376: Please change if modified. Click on History to see what's new.

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Receptors and carriers


Coagulation factors  






Retrograde transport to nucleus  


Anterograde transport to plasma membrane  

  • APP Involved in fast anterograde transport of Herpes simplex ( squid axon); Major component of viral particles [45]
  • APPBP2 Binds to tegument US11 product [46] and to APP [47]
  • KIF1A Binds to virion UL56 [48] Kinesins  
  • KIF5B Tegument, envelope proteins and viral particles associate with kinesin-1 [49]
  • Tubulins, MAPT :see above

Actin , myosin   and keratin   related


Other transport (mostly intracellular: endosome  , golgi  , ER , lysosome   )



  • ANXA1 Virion component [35] Annexins  
  • ANXA2 Virion component [35]
  • ANXA5 Virion Component [35]
  • GAP43 Tegument, envelope proteins and viral particles associate with GAP-43 [49]
  • SNAP25 associates with Tegument, envelope proteins and viral particles [49]
  • SNAPIN Binds to Glycoprotein J [55]
  • TGOLN2 associates with Tegument, envelope proteins and viral particles [49]

Intercellular spread    

  • HSV-1 binds to cell junction components [56]

HEAT SHOCK PROTEINS   and protein stress : Unfolded protein response  

HSPs can also act as viral receptors [57] [58]




Free radical Antioxidant


Ubiquitin proteasome and SUMO    


Cell cycle related  


Immune and defence


Cell signalling



  • Mitochondria, and tegument proteins UL41 and UL46, migrate to perinuclear regions, via microtubules, in infected cells [108]. Large clusters of mitochondria group around the virus [109]
  • TIMM50 Virion component [35]  
  • Mitochondrial DNA Deletion: UL12 deletes mitochondrial DNA [110]
  • SLC25A5 Binds to product of UL47 [111]
  • US3 tegument protein inhibits mitochondrial electron transport [112]  
  • Switch from aerobic to anaerobic glycolysis post-infection [113]  

Nuclear import export


Nuclear Proteins


Chromatin remodelling  


DNA Repair , replication, recombination


RNA binding splicing and Ribosomal  


Host transcription factors binding to the viral genome


HISTONES and Other DNA binding  

Histones can also act as surface receptors for bacteria [171] and viruses [172]






Viral reactivators

  • Activators of the capsaicin   receptor TRPV1 reactivate HSV-1 [205]
  • Cadmium can reactivate the virus in sensory ganglia [206]
  • CASP3 induces and inhibitors reduce reactivation [207]
  • Heat stress activates the virus in PC12 cells [208]
  • Histone deacetylase inhibitors can reactivate the virus in neuronal cells [209]  
  • CREM (ICER) represses LAT expression and reactivates the virus [210]
  • GAL9 knockdown ameliorates antiviral immune responses [211]
  • ICAM1 modifies resistance in mice [212]
  • IL6 can reactivate the virus [91]
  • Morphine can reactivate the virus in mice [213]
  • MMP9 knockdown increases survival in mice [214]
  • NGF deprivation reactivates the virus in vitro [215]
  • 17-beta-estradiol   reactivates the virus via ESR1 [216]
  • Stimulation of cAMP or protein kinase C pathways can reactivate the virus [217]
  • Theophylline, dibutyryl-cAMP and adrenaline can reactivate the virus in neuroblastoma cells [218]
  • Tetrodotoxin   and GABA   increase viral replication in neuronal culture [219]
  • Ultra-violet light can reactivate the cutaneous virus [220] and sunlight is a reactivation factor [221]
  • Stress related glucocorticoids suppress antiviral immunity [222]  

Viral inhibitors

  • Arginine   (NO precursor) suppresses viral growth [223]
  • Ascorbic acid   and dehydroascorbic acid   exert antiviral effects [224]
  • CREBZF (Zhangfei) inhibits viral replication [126]
  • PTGS2 : Cyclo-oxygenase 2 inhibition (bromfenac) can inhibit viral reactivation as can aspirin (and ibuprofen in vitro) [225] [226] [227] Indomethacin suppresses viral replication [228]
  • IFNG blocks viral reactivation (per se) [229] or with IFNA and IFNB [230]
  • IFNG induced NOS1 inhibits viral replication [231]
  • IL18 protects mice against viral infection [232]
  • CREB3 (LUMAN: human VP16 homolog) modifies latency and reactivation [233]
  • Lysine has been reported to be of benefit in human infections [234] (no clinical trial to support this)
  • NGF maintains latency in peripheral neurones [235]
  • Nitric oxide   inhibits viral replication [236] via S-nitrosylation of viral proteins [237]  
  • NOS2 knockouts are more susceptible to infection [238]
  • Ouabain   inhibits viral replication [239]
  • Poly-L-Histidine PL-lysine and PL-arginine have been reported to have antiviral properties [240]
  • Retinoic acid inhibits viral replication [241]  
  • Salivary proline-rich proteins (PRB1 e.g.) or cystatins (CST3 eg) bind to viral particles and inhibit replication [242]
  • Viral infection decreases glutathione levels: Glutathione inhibits HSV-1 replication [243]  
  • Vitamin E defficiency but not supplementation affects viral pathogenicity [244]
  • TNFR1 knockout increases viral replication and lethality [245]
  • Humic Acid exhibits viral fusion inhibition for HSV viruses

Antiviral plant and other extracts

  • Cajanus Cajan extracts [246]  
  • Carissa Edulis extracts [247]  
  • Curcumin   decreases HSV-1 infectivity [248]
  • Cyanovirin-N displays anti HSV-1 and anti HIV-1 properties [249]  
  • Humic Acid can have viral fusion inhibition activity
  • Neem extracts have antiviral activity in vitro[250]  
  • Extracts of marine alga Symphyocladia Latiuscula possess antiviral activity in vitro and in vivo [251]  
  • Pyridinium formate from coffee has antiviral activity in vitro [252]
  • Resveratrol can inhibit viral replication [253]  
  • Thai medicinal plant extracts including M.oleifera   A.odorata   and V.denticulata   active in vitro and in vivo [254]



Antiviral drugs and treatments  

  • Acyclovir and related [260]  
  • Silica gel [261]
  • No vaccine yet: Clinical trials   RSS feed  

Human diseases linked to Herpes simplex infection

  • Alzheimer's disease [262] Alzheimer's disease susceptibility genes and Herpes simplex [263]
  • HSV-1 infection in mice causes entorhinal cortex and hippocampal degeneration and memory loss as in Alzheimer's disease [264]
  • Atherosclerosis [265]
  • Bipolar disorder [266]
  • Diabetes Type 2 [267]
  • Multiple sclerosis [268]
  • Parkinson's disease [269]
  • Schizophrenia [270]

Genes modifying the risk of HSV-1 infection in Man


  1. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Shukla, D., Liu, J., Blaiklock, P., Shworak, N.W., Bai, X., Esko, J.D., Cohen, G.H., Eisenberg, R.J., Rosenberg, R.D., Spear, P.G. Cell. (1999) [Pubmed]
  2. A role for heparan sulfate in viral surfing. Oh, M.J., Akhtar, J., Desai, P., Shukla, D. Biochem. Biophys. Res. Commun. (2010) [Pubmed]
  3. Chondroitin sulfate characterized by the E-disaccharide unit is a potent inhibitor of herpes simplex virus infectivity and provides the virus binding sites on gro2C cells. Bergefall, K., Trybala, E., Johansson, M., Uyama, T., Naito, S., Yamada, S., Kitagawa, H., Sugahara, K., Bergström, T. J. Biol. Chem. (2005) [Pubmed]
  4. Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules. Tal-Singer, R., Peng, C., Ponce De Leon, M., Abrams, W.R., Banfield, B.W., Tufaro, F., Cohen, G.H., Eisenberg, R.J. J. Virol. (1995) [Pubmed]
  5. Heparan sulfate glycosaminoglycans as primary cell surface receptors for herpes simplex virus. Spear, P.G., Shieh, M.T., Herold, B.C., WuDunn, D., Koshy, T.I. Adv. Exp. Med. Biol. (1992) [Pubmed]
  6. Evidence for an interaction of herpes simplex virus with chondroitin sulfate proteoglycans during infection. Banfield, B.W., Leduc, Y., Esford, L., Visalli, R.J., Brandt, C.R., Tufaro, F. Virology. (1995) [Pubmed]
  7. Interaction of alpha-2-macroglobulin and HSV-1 during infection of neuronal cells. Alonso, M., Dimitrijevic, A., Recuero, M., Serrano, E., Valdivieso, F., López-Guerrero, J.A. J. Neurovirol. (2001) [Pubmed]
  8. Herpes simplex virus binds to human serum lipoprotein. Huemer, H.P., Menzel, H.J., Potratz, D., Brake, B., Falke, D., Utermann, G., Dierich, M.P. Intervirology. (1988) [Pubmed]
  9. Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN. de Jong, M.A., de Witte, L., Bolmstedt, A., van Kooyk, Y., Geijtenbeek, T.B. J. Gen. Virol. (2008) [Pubmed]
  10. Complement-independent binding of microorganisms to primate erythrocytes in vitro by cross-linked monoclonal antibodies via complement receptor 1. Powers, J.H., Buster, B.L., Reist, C.J., Martin, E., Bridges, M., Sutherland, W.M., Taylor, R.P., Scheld, W.M. Infect. Immun. (1995) [Pubmed]
  11. A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins. Perez, A., Li, Q.X., Perez-Romero, P., Delassus, G., Lopez, S.R., Sutter, S., McLaren, N., Fuller, A.O. J. Virol. (2005) [Pubmed]
  12. Mediation of virion penetration into vascular cells by association of basic fibroblast growth factor with herpes simplex virus type 1. Baird, A., Florkiewicz, R.Z., Maher, P.A., Kaner, R.J., Hajjar, D.P. Nature. (1990) [Pubmed]
  13. Fibroblast growth factor receptor is a portal of cellular entry for herpes simplex virus type 1. Kaner, R.J., Baird, A., Mansukhani, A., Basilico, C., Summers, B.D., Florkiewicz, R.Z., Hajjar, D.P. Science. (1990) [Pubmed]
  14. Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread. Li, Q., Ali, M.A., Cohen, J.I. Cell. (2006) [Pubmed]
  15. Herpes simplex virus glycoprotein D acquires mannose 6-phosphate residues and binds to mannose 6-phosphate receptors. Brunetti, C.R., Burke, R.L., Kornfeld, S., Gregory, W., Masiarz, F.R., Dingwell, K.S., Johnson, D.C. J. Biol. Chem. (1994) [Pubmed]
  16. Herpes simplex virus type 1 glycoprotein H binds to alphavbeta3 integrins. Parry, C., Bell, S., Minson, T., Browne, H. J. Gen. Virol. (2005) [Pubmed]
  17. Structurally homologous ligand binding of integrin Mac-1 and viral glycoprotein C receptors. Altieri, D.C., Etingin, O.R., Fair, D.S., Brunck, T.K., Geltosky, J.E., Hajjar, D.P., Edgington, T.S. Science. (1991) [Pubmed]
  18. Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses. Suenaga, T., Satoh, T., Somboonthum, P., Kawaguchi, Y., Mori, Y., Arase, H. Proc. Natl. Acad. Sci. U. S. A. (2010) [Pubmed]
  19. Nucleolin is required for efficient nuclear egress of herpes simplex virus type 1 nucleocapsids. Sagou, K., Uema, M., Kawaguchi, Y. J. Virol. (2010) [Pubmed]
  20. The anti-HIV cytokine midkine binds the cell surface-expressed nucleolin as a low affinity receptor. Said, E.A., Krust, B., Nisole, S., Svab, J., Briand, J.P., Hovanessian, A.G. J. Biol. Chem. (2002) [Pubmed]
  21. Entry of herpes simplex virus 1 and other alphaherpesviruses via the paired immunoglobulin-like type 2 receptor alpha. Arii, J., Uema, M., Morimoto, T., Sagara, H., Akashi, H., Ono, E., Arase, H., Kawaguchi, Y. J. Virol. (2009) [Pubmed]
  22. Glycoprotein D homologs in herpes simplex virus type 1, pseudorabies virus, and bovine herpes virus type 1 bind directly to human HveC(nectin-1) with different affinities. Connolly, S.A., Whitbeck, J.J., Rux, A.H., Krummenacher, C., van Drunen Littel-van den Hurk, S., Cohen, G.H., Eisenberg, R.J. Virology. (2001) [Pubmed]
  23. A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus. Warner, M.S., Geraghty, R.J., Martinez, W.M., Montgomery, R.I., Whitbeck, J.C., Xu, R., Eisenberg, R.J., Cohen, G.H., Spear, P.G. Virology. (1998) [Pubmed]
  24. Multiple receptor interactions trigger release of membrane and intracellular calcium stores critical for herpes simplex virus entry. Cheshenko, N., Liu, W., Satlin, L.M., Herold, B.C. Mol. Biol. Cell. (2007) [Pubmed]
  25. Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry. Krummenacher, C., Nicola, A.V., Whitbeck, J.C., Lou, H., Hou, W., Lambris, J.D., Geraghty, R.J., Spear, P.G., Cohen, G.H., Eisenberg, R.J. J. Virol. (1998) [Pubmed]
  26. Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry. Bender, F.C., Whitbeck, J.C., Ponce de Leon, M., Lou, H., Eisenberg, R.J., Cohen, G.H. J. Virol. (2003) [Pubmed]
  27. Anti-HSV activity of lactoferrin and lactoferricin is dependent on the presence of heparan sulphate at the cell surface. Andersen, J.H., Jenssen, H., Sandvik, K., Gutteberg, T.J. J. Med. Virol. (2004) [Pubmed]
  28. Herpes simplex virus triggers activation of calcium-signaling pathways. Cheshenko, N., Del Rosario, B., Woda, C., Marcellino, D., Satlin, L.M., Herold, B.C. J. Cell. Biol. (2003) [Pubmed]
  29. Coagulation initiated on herpesviruses. Sutherland, M.R., Raynor, C.M., Leenknegt, H., Wright, J.F., Pryzdial, E.L. Proc. Natl. Acad. Sci. U. S. A. (1997) [Pubmed]
  30. Involvement of the contact phase and intrinsic pathway in herpes simplex virus-initiated plasma coagulation. Gershom, E.S., Sutherland, M.R., Lollar, P., Pryzdial, E.L. J. Thromb. Haemost. (2010) [Pubmed]
  31. Herpes simplex virus type 1-encoded glycoprotein C contributes to direct coagulation factor X-virus binding. Livingston, J.R., Sutherland, M.R., Friedman, H.M., Pryzdial, E.L. Biochem. J. (2006) [Pubmed]
  32. Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells. Cheung, P., Panning, B., Smiley, J.R. J. Virol. (1997) [Pubmed]
  33. Activation of cellular promoters during herpes virus infection of biochemically transformed cells. Everett, R.D. EMBO. J. (1985) [Pubmed]
  34. Herpes simplex virus type 1 production requires a functional ESCRT-III complex but is independent of TSG101 and ALIX expression. Pawliczek, T., Crump, C.M. J. Virol. (2009) [Pubmed]
  35. Comprehensive characterization of extracellular herpes simplex virus type 1 virions. Loret, S., Guay, G., Lippé, R. J. Virol. (2008) [Pubmed]
  36. Cellular internalization of green fluorescent protein fused with herpes simplex virus protein VP22 via a lipid raft-mediated endocytic pathway independent of caveolae and Rho family GTPases but dependent on dynamin and Arf6. Nishi, K., Saigo, K. J. Biol. Chem. (2007) [Pubmed]
  37. The human DnaJ protein, hTid-1, enhances binding of a multimer of the herpes simplex virus type 1 UL9 protein to oris, an origin of viral DNA replication. Eom, C.Y., Lehman, I.R. Proc. Natl. Acad. Sci. U. S. A. (2002) [Pubmed]
  38. The herpes simplex virus 1 U(L)34 protein interacts with a cytoplasmic dynein intermediate chain and targets nuclear membrane. Ye, G.J., Vaughan, K.T., Vallee, R.B., Roizman, B. J. Virol. (2000) [Pubmed]
  39. Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport. Douglas, M.W., Diefenbach, R.J., Homa, F.L., Miranda-Saksena, M., Rixon, F.J., Vittone, V., Byth, K., Cunningham, A.L. J. Biol. Chem. (2004) [Pubmed]
  40. Eclipse phase of herpes simplex virus type 1 infection: Efficient dynein-mediated capsid transport without the small capsid protein VP26. Döhner, K., Radtke, K., Schmidt, S., Sodeik, B. J. Virol. (2006) [Pubmed]
  41. Herpes simplex virus tegument protein VP22 contains overlapping domains for cytoplasmic localization, microtubule interaction, and chromatin binding. Martin, A., O'Hare, P., McLauchlan, J., Elliott, G. J. Virol. (2002) [Pubmed]
  42. Herpes simplex virus type 1 tegument protein VP22 induces the stabilization and hyperacetylation of microtubules. Elliott, G., O'Hare, P. J. Virol. (1998) [Pubmed]
  43. Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1. Wozniak, M.A., Frost, A.L., Itzhaki, R.F. J. Alzheimers. Dis. (2009) [Pubmed]
  44. ICP0 dismantles microtubule networks in herpes simplex virus-infected cells. Liu, M., Schmidt, E.E., Halford, W.P. PLoS. One. (2010) [Pubmed]
  45. Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease. Satpute-Krishnan, P., DeGiorgis, J.A., Bearer, E.L. Aging. Cell. (2003) [Pubmed]
  46. Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides. Benboudjema, L., Mulvey, M., Gao, Y., Pimplikar, S.W., Mohr, I. J. Virol. (2003) [Pubmed]
  47. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Zheng, P., Eastman, J., Vande Pol, S., Pimplikar, S.W. Proc. Natl. Acad. Sci. U. S. A. (1998) [Pubmed]
  48. Herpes simplex virus type 2 membrane protein UL56 associates with the kinesin motor protein KIF1A. Koshizuka, T., Kawaguchi, Y., Nishiyama, Y. J. Gen. Virol. (2005) [Pubmed]
  49. Herpes simplex virus utilizes the large secretory vesicle pathway for anterograde transport of tegument and envelope proteins and for viral exocytosis from growth cones of human fetal axons. Miranda-Saksena, M., Boadle, R.A., Aggarwal, A., Tijono, B., Rixon, F.J., Diefenbach, R.J., Cunningham, A.L. J. Virol. (2009) [Pubmed]
  50. Evidence of a role for nonmuscle myosin II in herpes simplex virus type 1 egress. van Leeuwen, H., Elliott, G., O'Hare, P. J. Virol. (2002) [Pubmed]
  51. Alpha-herpesvirus infection induces the formation of nuclear actin filaments. Feierbach, B., Piccinotti, S., Bisher, M., Denk, W., Enquist, L.W. PLoS. Pathog. (2006) [Pubmed]
  52. Phosphorylation of cytokeratin 17 by herpes simplex virus type 2 US3 protein kinase. Murata, T., Goshima, F., Nishizawa, Y., Daikoku, T., Takakuwa, H., Ohtsuka, K., Yoshikawa, T., Nishiyama, Y. Microbiol. Immunol. (2002) [Pubmed]
  53. Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cells. Hoppe, S., Schelhaas, M., Jaeger, V., Liebig, T., Petermann, P., Knebel-Mörsdorf, D. J. Gen. Virol. (2006) [Pubmed]
  54. Protein kinase D-dependent trafficking of the large Herpes simplex virus type 1 capsids from the TGN to plasma membrane. Rémillard-Labrosse, G., Mihai, C., Duron, J., Guay, G., Lippé, R. Traffic. (2009) [Pubmed]
  55. The antiapoptotic herpes simplex virus glycoprotein J localizes to multiple cellular organelles and induces reactive oxygen species formation. Aubert, M., Chen, Z., Lang, R., Dang, C.H., Fowler, C., Sloan, D.D., Jerome, K.R. J. Virol. (2008) [Pubmed]
  56. The herpes simplex virus gE-gI complex facilitates cell-to-cell spread and binds to components of cell junctions. Dingwell, K.S., Johnson, D.C. J. Virol. (1998) [Pubmed]
  57. Heat shock protein 70 on Neuro2a cells is a putative receptor for Japanese encephalitis virus. Das, S., Laxminarayana, S.V., Chandra, N., Ravi, V., Desai, A. Virology. (2009) [Pubmed]
  58. GRP78, a coreceptor for coxsackievirus A9, interacts with major histocompatibility complex class I molecules which mediate virus internalization. Triantafilou, K., Fradelizi, D., Wilson, K., Triantafilou, M. J. Virol. (2002) [Pubmed]
  59. Herpes simplex virus type 1 glycoprotein B requires a cysteine residue at position 633 for folding, processing, and incorporation into mature infectious virus particles. Laquerre, S., Anderson, D.B., Argnani, R., Glorioso, J.C. J. Virol. (1998) [Pubmed]
  60. Calnexin associates with the precursors of glycoproteins B, C, and D of herpes simplex virus type 1. Yamashita, Y., Yamada, M., Daikoku, T., Yamada, H., Tadauchi, A., Tsurumi, T., Nishiyama, Y. Virology. (1996) [Pubmed]
  61. Activation of the herpes simplex virus type-1 origin-binding protein (UL9) by heat shock proteins. Tanguy Le Gac, N., Boehmer, P.E. J. Biol. Chem. (2002) [Pubmed]
  62. Nuclear sequestration of cellular chaperone and proteasomal machinery during herpes simplex virus type 1 infection. Burch, A.D., Weller, S.K. J. Virol. (2004) [Pubmed]
  63. Herpes simplex virus type 1 DNA polymerase requires the mammalian chaperone hsp90 for proper localization to the nucleus. Burch, A.D., Weller, S.K. J. Virol. (2005) [Pubmed]
  64. Conformation-defective herpes simplex virus 1 glycoprotein B activates the promoter of the grp94 gene that codes for the 94-kD stress protein in the endoplasmic reticulum. Ramakrishnan, M., Tugizov, S., Pereira, L., Lee, A.S. DNA. Cell. Biol. (1995) [Pubmed]
  65. Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor. Mulvey, M., Arias, C., Mohr, I. J. Virol. (2007) [Pubmed]
  66. Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8. Taylor, T.J., Knipe, D.M. J. Virol. (2004) [Pubmed]
  67. The principal hydrogen donor for the herpes simplex virus type 1-encoded ribonucleotide reductase in infected cells is a cellular thioredoxin. Darling, A.J. J. Gen. Virol. (1988) [Pubmed]
  68. [Herpes simplex virus type 1 ICP27 induces apoptotic cell death by increasing intracellular reactive oxygen species]. Kim, J.C., Choi, S.H., Kim, J.K., Kim, Y., Kim, H.J., Im, J.S., Lee, S.Y., Choi, J.M., Lee, H.M., Ahn, J.K. Mol. Biol. (Mosk). (2008) [Pubmed]
  69. Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces. Liang, Y., Kurakin, A., Roizman, B. Proc. Natl. Acad. Sci. U. S. A. (2005) [Pubmed]
  70. The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity. Van Sant, C., Hagglund, R., Lopez, P., Roizman, B. Proc. Natl. Acad. Sci. U. S. A. (2001) [Pubmed]
  71. Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway. Eom, C.Y., Lehman, I.R. Proc. Natl. Acad. Sci. U. S. A. (2003) [Pubmed]
  72. Herpes simplex virus UL56 interacts with and regulates the Nedd4-family ubiquitin ligase Itch. Ushijima, Y., Luo, C., Kamakura, M., Goshima, F., Kimura, H., Nishiyama, Y. Virol. J. (2010) [Pubmed]
  73. A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. Lilley, C.E., Chaurushiya, M.S., Boutell, C., Landry, S., Suh, J., Panier, S., Everett, R.D., Stewart, G.S., Durocher, D., Weitzman, M.D. EMBO. J. (2010) [Pubmed]
  74. Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease. Bailey, D., O'Hare, P. J. Gen. Virol. (2002) [Pubmed]
  75. Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0. Hagglund, R., Roizman, B. Proc. Natl. Acad. Sci. U. S. A. (2002) [Pubmed]
  76. The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a. Gu, H., Roizman, B. Proc. Natl. Acad. Sci. U. S. A. (2003) [Pubmed]
  77. Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7. Boutell, C., Canning, M., Orr, A., Everett, R.D. J. Virol. (2005) [Pubmed]
  78. ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells. Kalamvoki, M., Roizman, B. Proc. Natl. Acad. Sci. U. S. A. (2009) [Pubmed]
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