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Chemical Compound Review:

p-Dithane 1,4-dithiane

Synonyms: p-Dithiane, para-Dithiane, CHEBI:540, CCRIS 3240, HSDB 7426, ...

Polce, M.J. et al., Lee, H. et al., Schieferstein, G.J. et al.

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Disease relevance of p-Dithiane

Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test [1].
Subchronic toxicity study of 1,4-dithiane in the rat [2].

High impact information on p-Dithiane

The distonic radical ion .CH2CH2SCH2+ (1+.), generated by dissociative electron ionization of 1,4-dithiane or 1,4-thioxane, is identified in the gas phase by its collisionally activated dissociation (CAD), neutralization -reionization (+NR+) and charge-reversal (+CR-) mass spectra [3].
This study reports a novel form of toxicity (deposition of anisotrophic crystals in the olfactory mucosa) from 1,4-dithiane administered by gavage [2].

Associations of p-Dithiane with other chemical compounds

1,3-Dithiane and 1,4-dithiane are the sulfur-containing Maillard reaction products (MRPs) which have been found in boiled beef extracts [1].

References

Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test. Lee, H., Bian, S.S., Chen, Y.L. Mutat. Res. (1994) [Pubmed]
Subchronic toxicity study of 1,4-dithiane in the rat. Schieferstein, G.J., Sheldon, W.G., Cantrell, S.A., Reddy, G. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1988) [Pubmed]
Distonic ion .CH2CH2SCH2+ and the isomeric trimethylene and propylene sulfide radical cations. Assessment of structures and reactivities via decomposition and redox reactions. Polce, M.J., Wesdemiotis, C. Rapid Commun. Mass Spectrom. (1996) [Pubmed]

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