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Chemical Compound Review

SP-Camp-S     (1R,6R,8R,9R)-8-(6- aminopurin-9-yl)-3-oxo...

Synonyms:
 
 
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High impact information on SP-Camp-S

 

Biological context of SP-Camp-S

 

Anatomical context of SP-Camp-S

  • Isoprenaline-mediated relaxation was partially reduced by endothelium removal and the presence of the NO synthase inhibitor N(G)-monomethyl-l-arginine (0.1 mmol/L), but not by the cAMP antagonist (Rp)-cyclic adenosine-3',5'-monophosphorothioate (Rp-cAMPS; 0.5 mmol/L) [6].
  • To define more clearly the role of cAMP in receptor-mediated smooth muscle relaxation, we used a specific competitive antagonist of the action of cAMP on protein kinase A, (R)-p-adenosine 3',5'-cyclic phosphorothioate [(R)-p-cAMPS], and its S isomer, (S)-p-cAMPS, which functions as a cAMP agonist [7].
  • In taenia coli muscle cells, VIP did not increase NO production or cGMP levels: relaxation was accompanied by an increase in cAMP and was partly inhibited by (R)-p-cAMPS and KT5823 and abolished by a combination of both inhibitors [8].
 

Gene context of SP-Camp-S

  • (R)-p-cAMPS inhibited VIP-induced relaxation, with a rightward shift in the VIP dose-response curve, suggesting competitive antagonism [7].

References

  1. Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. Masciarelli, S., Horner, K., Liu, C., Park, S.H., Hinckley, M., Hockman, S., Nedachi, T., Jin, C., Conti, M., Manganiello, V. J. Clin. Invest. (2004) [Pubmed]
  2. Cell signalling and the hormonal stimulation of the hepatic glycine cleavage enzyme system by glucagon. Mabrouk, G.M., Jois, M., Brosnan, J.T. Biochem. J. (1998) [Pubmed]
  3. Vasoactive intestinal polypeptide and neuropeptide Y act indirectly to increase neurite outgrowth of dissociated dorsal root ganglion cells. White, D.M., Mansfield, K. Neuroscience (1996) [Pubmed]
  4. Hypothalamic administration of cAMP agonist/PKA activator inhibits both schedule feeding and NPY-induced feeding in rats. Sheriff, S., Chance, W.T., Iqbal, S., Rizvi, T.A., Xiao, C., Kasckow, J.W., Balasubramaniam, A. Peptides (2003) [Pubmed]
  5. Galanin induces opposite effects via different intracellular pathways in smooth muscle cells from dog colon. Botella, A., Delvaux, M., Fioramonti, J., Frexinos, J., Bueno, L. Peptides (1994) [Pubmed]
  6. ENDOGENOUS NITRIC OXIDE ATTENUATES beta-ADRENOCEPTOR-MEDIATED RELAXATION IN RAT AORTA. Kang, K.B., van der Zypp, A., Majewski, H. Clin. Exp. Pharmacol. Physiol. (2007) [Pubmed]
  7. A primary role for protein kinase A in smooth muscle relaxation induced by adrenergic agonists and neuropeptides. Gu, Z.F., Jensen, R.T., Maton, P.N. Am. J. Physiol. (1992) [Pubmed]
  8. Activation of distinct cAMP- and cGMP-dependent pathways by relaxant agents in isolated gastric muscle cells. Jin, J.G., Murthy, K.S., Grider, J.R., Makhlouf, G.M. Am. J. Physiol. (1993) [Pubmed]
 
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