Chemical Compound Review:
CHEMBL16192 (7S,8S)-7-benzhydryl-N-[(2...
Synonyms:
SureCN675159, SureCN675160, CHEBI:116524, AC1L2XRE, CP-96345, ...
Tan-No,
Taira,
Wako,
Niijima,
Nakagawasai,
Tadano,
Sakurada,
Sakurada,
Kisara,
Wershil,
Castagliuolo,
Pothoulakis,
- Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist. Gether, U., Johansen, T.E., Snider, R.M., Lowe, J.A., Nakanishi, S., Schwartz, T.W. Nature (1993)
- Selective inhibition of the carotid body sensory response to hypoxia by the substance P receptor antagonist CP-96,345. Prabhakar, N.R., Cao, H., Lowe, J.A., Snider, R.M. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes. Lai, J.P., Ho, W.Z., Zhan, G.X., Yi, Y., Collman, R.G., Douglas, S.D. Proc. Natl. Acad. Sci. U.S.A. (2001)
- CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. Pothoulakis, C., Castagliuolo, I., LaMont, J.T., Jaffer, A., O'Keane, J.C., Snider, R.M., Leeman, S.E. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Synergistic role of muscarinic acetylcholine and tachykinin NK-2 receptors in intestinal peristalsis. Holzer, P., Maggi, C.A. Naunyn Schmiedebergs Arch. Pharmacol. (1994)
- Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. Fong, T.M., Cascieri, M.A., Yu, H., Bansal, A., Swain, C., Strader, C.D. Nature (1993)
- Functional neurokinin 1 receptors for substance P are expressed by human vascular endothelium. Greeno, E.W., Mantyh, P., Vercellotti, G.M., Moldow, C.F. J. Exp. Med. (1993)
- Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs. Solway, J., Kao, B.M., Jordan, J.E., Gitter, B., Rodger, I.W., Howbert, J.J., Alger, L.E., Necheles, J., Leff, A.R., Garland, A. J. Clin. Invest. (1993)
- Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice. Wershil, B.K., Castagliuolo, I., Pothoulakis, C. Gastroenterology (1998)
- Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea. Bertrand, C., Geppetti, P., Baker, J., Yamawaki, I., Nadel, J.A. J. Immunol. (1993)
- An isobolographic analysis of the effects of N-methyl-D-aspartate and NK1 tachykinin receptor antagonists on inflammatory hyperalgesia in the rat. Ren, K., Iadarola, M.J., Dubner, R. Br. J. Pharmacol. (1996)
- Effect of bradykinin and tachykinin receptor antagonist on xylene-induced cystitis in rats. Giuliani, S., Santicioli, P., Lippe, I.T., Lecci, A., Maggi, C.A. J. Urol. (1993)
- Comparison of antagonistic effects of sendide and CP-96,345 on a spinally mediated behavioural response in mice. Sakurada, T., Manome, Y., Katsumata, K., Tan-No, K., Sakurada, S., Ohba, M., Kisara, K. Eur. J. Pharmacol. (1994)
- Effect of CP-96,345, a nonpeptide substance P receptor antagonist, on salivation in rats. Snider, R.M., Longo, K.P., Drozda, S.E., Lowe, J.A., Leeman, S.E. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Role of substance P in blood pressure regulation in salt-dependent experimental hypertension. Kohlmann, O., Cesaretti, M.L., Ginoza, M., Tavares, A., Zanella, M.T., Ribeiro, A.B., Ramos, O.L., Leeman, S.E., Gavras, I., Gavras, H. Hypertension (1997)
- Multiple mechanisms of arachidonic acid release in Chinese hamster ovary cells transfected with cDNA of substance P receptor. Garcia, M., Sakamoto, K., Shigekawa, M., Nakanishi, S., Ito, S. Biochem. Pharmacol. (1994)
- A non-peptide substance P antagonist down-regulates SP mRNA expression in human mononuclear phagocytes. Lai, J.P., Ho, W.Z., Yang, J.H., Wang, X., Song, L., Douglas, S.D. J. Neuroimmunol. (2002)
- Non-peptide antagonists, CP-96,345 and RP 67580, distinguish species variants in tachykinin NK1 receptors. Barr, A.J., Watson, S.P. Br. J. Pharmacol. (1993)
- Injury-induced plasticity of spinal reflex activity: NK1 neurokinin receptor activation and enhanced A- and C-fiber mediated responses in the rat spinal cord in vitro. Thompson, S.W., Dray, A., Urban, L. J. Neurosci. (1994)
- Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission. Haddjeri, N., Blier, P. Biol. Psychiatry (2001)
- Involvement of tachykinin receptors (NK1 and NK2) in sodium metabisulfite-induced airway effects. Sakamoto, T., Tsukagoshi, H., Barnes, P.J., Chung, K.F. Am. J. Respir. Crit. Care Med. (1994)
- Cardiovascular effects of a specific nonpeptide antagonist of substance P (NK-1) receptor in DOCA-salt hypertension. Kohlmann, O., Ginoza, M., Cezaretti, M.L., Zanella, M.T., Ribeiro, A.B., Tavares, A., Ramos, O.L., Leeman, S.E., Gavras, I., Gavras, H. Hypertension (1995)
- The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors. Jensen, C.J., Gerard, N.P., Schwartz, T.W., Gether, U. Mol. Pharmacol. (1994)
- Intrathecally administered spermine produces the scratching, biting and licking behaviour in mice. Tan-No, K., Taira, A., Wako, K., Niijima, F., Nakagawasai, O., Tadano, T., Sakurada, C., Sakurada, T., Kisara, K. Pain (2000)
- Substance P and somatostatin can modulate the amount of IgG2a secreted in response to schistosome egg antigens in murine schistosomiasis mansoni. Blum, A.M., Metwali, A., Mathew, R.C., Elliott, D., Weinstock, J.V. J. Immunol. (1993)
- Substance P modulates antigen-induced, IFN-gamma production in murine Schistosomiasis mansoni. Blum, A.M., Metwali, A., Cook, G., Mathew, R.C., Elliott, D., Weinstock, J.V. J. Immunol. (1993)
- Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences. Belvisi, M.G., Patacchini, R., Barnes, P.J., Maggi, C.A. Br. J. Pharmacol. (1994)
- Characterization of guinea pig pulmonary neurokinin type 1 receptors using a novel antagonist ligand, [3H]FK888. Miyayasu, K., Mak, J.C., Nishikawa, M., Barnes, P.J. Mol. Pharmacol. (1993)
- Nonadrenergic, noncholinergic contractile responses of the guinea pig hilar bronchus involve the preferential activation of tachykinin neurokinin2 receptors. Renzetti, L.M., Shenvi, A., Buckner, C.K. J. Pharmacol. Exp. Ther. (1992)
- Effects of FK224, a novel cyclopeptide NK1 and NK2 antagonist, and CP-96,345, a nonpeptide NK1 antagonist, on development and maintenance of thermal hyperesthesia evoked by carrageenan injection in the rat paw. Yamamoto, T., Shimoyama, N., Mizuguchi, T. Anesthesiology (1993)