Chemical Compound Review:
SureCN1807093 3-[3-butylsulfanyl-1-[(4...
Synonyms:
AC1L2XXZ, LS-183392
- Prevention of endogenous leukotriene production during anaphylaxis in the guinea pig by an inhibitor of leukotriene biosynthesis (MK-886) but not by dexamethasone. Guhlmann, A., Keppler, A., Kästner, S., Krieter, H., Brückner, U.B., Messmer, K., Keppler, D. J. Exp. Med. (1989)
- Induction by chemokines of lipid mediator synthesis in granulocyte-macrophage colony-stimulating factor-treated human neutrophils. McDonald, P.P., Pouliot, M., Borgeat, P., McColl, S.R. J. Immunol. (1993)
- Phorbol ester-induced leukotriene biosynthesis and tumor promotion in mouse epidermis. Fürstenberger, G., Csuk-Glänzer, B.I., Marks, F., Keppler, D. Carcinogenesis (1994)
- Suppression of intimal hyperplasia by a 5-lipoxygenase inhibitor, MK-886: studies with a photochemical model of endothelial injury. Kondo, K., Umemura, K., Ohmura, T., Hashimoto, H., Nakashima, M. Thromb. Haemost. (1998)
- Role of leukotrienes in airway hyperresponsiveness in guinea-pigs. Ishida, K., Thomson, R.J., Schellenberg, R.R. Br. J. Pharmacol. (1993)
- Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Dixon, R.A., Diehl, R.E., Opas, E., Rands, E., Vickers, P.J., Evans, J.F., Gillard, J.W., Miller, D.K. Nature (1990)
- Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. Voelkel, N.F., Tuder, R.M., Wade, K., Höper, M., Lepley, R.A., Goulet, J.L., Koller, B.H., Fitzpatrick, F. J. Clin. Invest. (1996)
- 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. Woods, J.W., Coffey, M.J., Brock, T.G., Singer, I.I., Peters-Golden, M. J. Clin. Invest. (1995)
- Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Lam, B.K., Penrose, J.F., Freeman, G.J., Austen, K.F. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Activation of the human neutrophil 5-lipoxygenase by leukotriene B4. McDonald, P.P., McColl, S.R., Naccache, P.H., Borgeat, P. Br. J. Pharmacol. (1992)
- Chronic leukotriene inhibition in the rat fails to modify the toxicological effects of a cyclooxygenase inhibitor. Ford-Hutchinson, A.W., Tagari, P., Ching, S.V., Anderson, C.A., Coleman, J.B., Peter, C.P. Can. J. Physiol. Pharmacol. (1993)
- Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis. Benjamim, C.F., Canetti, C., Cunha, F.Q., Kunkel, S.L., Peters-Golden, M. J. Immunol. (2005)
- In vitro airway and tissue response to antigen in sensitized rats. Role of serotonin and leukotriene D4. Nagase, T., Fukuchi, Y., Dallaire, M.J., Martin, J.G., Ludwig, M.S. Am. J. Respir. Crit. Care Med. (1995)
- Biochemical activity, pharmacokinetics, and tolerability of MK-886, a leukotriene biosynthesis inhibitor, in humans. Depre, M., Friedman, B., Tanaka, W., Van Hecken, A., Buntinx, A., DeSchepper, P.J. Clin. Pharmacol. Ther. (1993)
- Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents. Rioux, N., Castonguay, A. Carcinogenesis (1998)
- 5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae. Mancuso, P., Standiford, T.J., Marshall, T., Peters-Golden, M. Infect. Immun. (1998)
- Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. Weddle, D.L., Tithoff, P., Williams, M., Schuller, H.M. Carcinogenesis (2001)
- The importance of leukotrienes in mast cell-mediated Toxoplasma gondii cytotoxicity. Henderson, W.R., Chi, E.Y. J. Infect. Dis. (1998)
- Nordihydroguaiaretic acid (NDGA) blocks the differentiation of C2C12 myoblast cells. Ito, H., Ueda, H., Iwamoto, I., Inaguma, Y., Takizawa, T., Asano, T., Kato, K. J. Cell. Physiol. (2005)
- Inhibitory effects of MK-886 on arachidonic acid metabolism in human phagocytes. Ménard, L., Pilote, S., Naccache, P.H., Laviolette, M., Borgeat, P. Br. J. Pharmacol. (1990)
- Calcium-dependent eicosanoid metabolism by concanavalin A-stimulated human monocytes in vitro. Synergism with phorbol ester indicates separate regulation of leukotriene B4 synthesis and release. Hoffman, T., Brando, C., Lizzio, E.F., Lee, Y.L., Hansen, M., Tripathi, A.K., Taplits, M., Puri, J., Bonvini, E., Abrahamsen, T.G. J. Immunol. (1991)
- Cellular oxygenation of 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid by 5-lipoxygenase is stimulated by 5-lipoxygenase-activating protein. Mancini, J.A., Waterman, H., Riendeau, D. J. Biol. Chem. (1998)
- Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis. Mancini, J.A., Blood, K., Guay, J., Gordon, R., Claveau, D., Chan, C.C., Riendeau, D. J. Biol. Chem. (2001)
- 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors. Evans, J.F., Lévillé, C., Mancini, J.A., Prasit, P., Thérien, M., Zamboni, R., Gauthier, J.Y., Fortin, R., Charleson, P., MacIntyre, D.E. Mol. Pharmacol. (1991)
- Tumour necrosis factor-alpha mediates carrageenin-induced knee-joint incapacitation and also triggers overt nociception in previously inflamed rat knee-joints. Tonussi, C.R., Ferreira, S.H. Pain (1999)
- Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity. Werz, O., Szellas, D., Henseler, M., Steinhilber, D. Mol. Pharmacol. (1998)
- Chemokine secretion by human polymorphonuclear granulocytes after stimulation with Mycobacterium tuberculosis and lipoarabinomannan. Riedel, D.D., Kaufmann, S.H. Infect. Immun. (1997)
- Induced microsomal PGE synthase-1 is involved in cyclooxygenase-2-dependent PGE2 production in gastric fibroblasts. Shinji, Y., Tsukui, T., Tatsuguchi, A., Shinoki, K., Kusunoki, M., Suzuki, K., Hiratsuka, T., Wada, K., Futagami, S., Miyake, K., Gudis, K., Sakamoto, C. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice. Jawien, J., Gajda, M., Rudling, M., Mateuszuk, L., Olszanecki, R., Guzik, T.J., Cichocki, T., Chlopicki, S., Korbut, R. Eur. J. Clin. Invest. (2006)
- Do eicosanoids cause colonic dysfunction in experimental E coli O157:H7 (EHEC) infection? Bell, C.J., Elliott, E.J., Wallace, J.L., Redmond, D.M., Payne, J., Li, Z., O'Loughlin, E.V. Gut (2000)
- Platelets, neutrophils, and vasoconstriction after arterial injury by angioplasty in pigs: effects of MK-886, a leukotriene biosynthesis inhibitor. Provost, P., Borgeat, P., Merhi, Y. Br. J. Pharmacol. (1998)