Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

pyruvate 2-oxopropanoic acid

Synonyms: Pyroracemate, Acetylformate, CH3COCOOH, Pyruvic acid, NSC-179, ...

Girbal, L. et al., Schieberle, P. et al.

Schieberle, Köhler, Granvog,

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Disease relevance of pyruvic acid

Glycerol-glucose-fed (molar ratio of 2) chemostat cultures of Clostridium acetobutylicum were glucose limited but glycerol sufficient and had a high intracellular NADH/NAD ratio (I. Vasconcelos, L. Girbal, and P. Soucaille, J. Bacteriol. 176:1443-1450, 1994) [1].

High impact information on pyruvic acid

Quantitation of AA formed either under aqueous conditions or in low water model systems revealed glucose and 2-oxopropionic acid as the most effective compounds in AA generation, when reacted in model systems with a low water content (about 1 mol-% yield) [2].

References

Regulation of Clostridium acetobutylicum metabolism as revealed by mixed-substrate steady-state continuous cultures: role of NADH/NAD ratio and ATP pool. Girbal, L., Soucaille, P. J. Bacteriol. (1994) [Pubmed]
New aspects on the formation and analysis of acrylamide. Schieberle, P., Köhler, P., Granvog, M. Adv. Exp. Med. Biol. (2005) [Pubmed]

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