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Chemical Compound Review

Funduscein     disodium 2-(6-oxido-3-oxo-xanthen-9...

Synonyms: Ak-Fluor, Ful-Glo, AC1MVAYI, Floures (TN), Aizen uranine, ...
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Disease relevance of fluorescein


Psychiatry related information on fluorescein


High impact information on fluorescein

  • The capillaries within the metastatic foci were enlarged and irregular, but there was no leakage of sodium fluorescein, showing that the blood-brain barrier was intact [1].
  • Moreover, when alphaIIb(P145A) and beta3 were stably coexpressed in Chinese hamster ovary cells, alphaIIbbeta3 was readily detected on the cell surface, but the cells were unable to adhere to immobilized fibrinogen or to bind soluble fluorescein isothiocyanate-fibrinogen after alphaIIbbeta3 activation by the activating monoclonal antibody PT25-2 [7].
  • Extravasation of sodium fluorescein (MW, 386), but not 150 kDa (MW) fluorescein isothiocyanate-dextran, occurred in the area postrema under control conditions [8].
  • After a certain period of time filtered ultraviolet light produces platelet aggregation in microvessels on the cerebral surface of the mouse, but only when sodium fluorescein is first injected intravascularly to provide a light-absorbing, heat-generating target [9].
  • The low vascular permeability of HGL21, which was also confirmed by both sodium fluorescein and Lissamine green injections, suggests that not all tumors are leaky to tracer molecules and that the blood-tumor barrier of this tumor still possesses some characteristics of blood-brain barrier as observed in other intracranial tumors [10].

Chemical compound and disease context of fluorescein


Biological context of fluorescein


Anatomical context of fluorescein


Associations of fluorescein with other chemical compounds


Gene context of fluorescein


Analytical, diagnostic and therapeutic context of fluorescein


  1. Macrophage infiltration into experimental brain metastases: occurrence through an intact blood-brain barrier. Schackert, G., Simmons, R.D., Buzbee, T.M., Hume, D.A., Fidler, I.J. J. Natl. Cancer Inst. (1988) [Pubmed]
  2. Sympathetic mediated vasomotion and skin capillary permeability in diabetic patients with peripheral neuropathy. Lefrandt, J.D., Bosma, E., Oomen, P.H., Hoeven, J.H., Roon, A.M., Smit, A.J., Hoogenberg, K. Diabetologia (2003) [Pubmed]
  3. Systemically expressed soluble Tie2 inhibits intraocular neovascularization. Hangai, M., Moon, Y.S., Kitaya, N., Chan, C.K., Wu, D.Y., Peters, K.G., Ryan, S.J., Hinton, D.R. Hum. Gene Ther. (2001) [Pubmed]
  4. Digital cutaneous fluorometry: correlation between blood flow and fluorescence. Bongard, F.S., Upton, R.A., Elings, V.B., Lewis, F.R. J. Vasc. Surg. (1984) [Pubmed]
  5. Evaluation of sodium fluorescein for quantitative diagnosis of root caries. van der Veen, M.H., Tsuda, H., Arends, J., ten Bosch, J.J. J. Dent. Res. (1996) [Pubmed]
  6. On the mechanism of potentiation of apomorphine-induced stereotypy due to electroconvulsive shock. Gulati, A., Srimal, R.C., Dhawan, K.N., Dhawan, B.N. Neuropharmacology (1987) [Pubmed]
  7. A naturally occurring mutation near the amino terminus of alphaIIb defines a new region involved in ligand binding to alphaIIbbeta3. Basani, R.B., French, D.L., Vilaire, G., Brown, D.L., Chen, F., Coller, B.S., Derrick, J.M., Gartner, T.K., Bennett, J.S., Poncz, M. Blood (2000) [Pubmed]
  8. Microcirculation of the area postrema. Permeability and vascular responses. Faraci, F.M., Choi, J., Baumbach, G.L., Mayhan, W.G., Heistad, D.D. Circ. Res. (1989) [Pubmed]
  9. Platelet aggregation in the cerebral microcirculation: effect of aspirin and other agents. Rosenblum, W.I., El-Sabban, F. Circ. Res. (1977) [Pubmed]
  10. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Yuan, F., Salehi, H.A., Boucher, Y., Vasthare, U.S., Tuma, R.F., Jain, R.K. Cancer Res. (1994) [Pubmed]
  11. Blood-brain barrier changes during compensated and decompensated hemorrhagic shock. Krizbai, I.A., Lenzser, G., Szatmari, E., Farkas, A.E., Wilhelm, I., Fekete, Z., Erdos, B., Bauer, H., Bauer, H.C., Sandor, P., Komjati, K. Shock (2005) [Pubmed]
  12. Effect of MK-801 and U83836E on a porcine brain capillary endothelial cell barrier during hypoxia. Giese, H., Mertsch, K., Blasig, I.E. Neurosci. Lett. (1995) [Pubmed]
  13. The survival of adenovirus in multidose bottles of topical fluorescein. Kowalski, R.P., Romanowski, E.G., Waikhom, B., Gordon, Y.J. Am. J. Ophthalmol. (1998) [Pubmed]
  14. Permeability of small coronary arteries and myocardial injury in hypertensive diabetic rats. Kubota, I., Fukuhara, T., Kinoshita, M. International journal of cardiology. (1990) [Pubmed]
  15. Acute onset of halos and glare: bilateral corneal epithelial edema with cystic eruptions--atypical presentation of amiodarone keratopathy. Dovie, J.M., Gurwood, A.S. Optometry (St. Louis, Mo.) (2006) [Pubmed]
  16. Puromycin-based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood-brain barrier-specific properties. Perrière, N., Demeuse, P., Garcia, E., Regina, A., Debray, M., Andreux, J.P., Couvreur, P., Scherrmann, J.M., Temsamani, J., Couraud, P.O., Deli, M.A., Roux, F. J. Neurochem. (2005) [Pubmed]
  17. Fluorescein and fluorescein glucuronide pharmacokinetics after intravenous injection. Blair, N.P., Evans, M.A., Lesar, T.S., Zeimer, R.C. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
  18. First clinical implications of perioperative red cell volume measurement with a nonradioactive marker (sodium fluorescein). Orth, V.H., Rehm, M., Thiel, M., Kreimeier, U., Haller, M., Brechtelsbauer, H., Finsterer, U. Anesth. Analg. (1998) [Pubmed]
  19. Adrenomedullin regulates blood-brain barrier functions in vitro. Kis, B., Deli, M.A., Kobayashi, H., Abrahám, C.S., Yanagita, T., Kaiya, H., Isse, T., Nishi, R., Gotoh, S., Kangawa, K., Wada, A., Greenwood, J., Niwa, M., Yamashita, H., Ueta, Y. Neuroreport (2001) [Pubmed]
  20. Transport of a hydrophilic compound into the cerebrospinal fluid during experimental allergic encephalomyelitis and after lipopolysaccharide administration. de Vries, H.E., Eppens, E.F., Prins, M., Kuiper, J., van Berkel, T.J., de Boer, A.G., Breimer, D.D. Pharm. Res. (1995) [Pubmed]
  21. Biliary secretion of sodium fluorescein in primary monolayer cultures of adult rat hepatocytes and its stimulation by nicotinamide. Gebhardt, R., Jung, W. J. Cell. Sci. (1982) [Pubmed]
  22. Nitric oxide and cGMP regulate endothelial permeability and F-actin distribution in hydrogen peroxide-treated endothelial cells. Liu, S.M., Sundqvist, T. Exp. Cell Res. (1997) [Pubmed]
  23. Passage of molecules across the intercellular bridge between post-mitotic daughter cells. Schulze, E.S., Blose, S.H. Exp. Cell Res. (1984) [Pubmed]
  24. Ultrastructure of blood-retinal barrier permeability in rat phototoxic retinopathy. Korte, G.E., Bellhorn, R.W., Burns, M.S. Invest. Ophthalmol. Vis. Sci. (1983) [Pubmed]
  25. Comparison of prednisolone and RMI-1068 in the ocular irritative response in dogs. Dziezyc, J., Millichamp, N.J., Rohde, B.H., Smith, W.B. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  26. Hepatic transport of fluorescent molecules: in vivo studies using intravital TV microscopy. Sherman, I.A., Fisher, M.M. Hepatology (1986) [Pubmed]
  27. Bovine and Porcine Transscleral Solute Transport: Influence of Lipophilicity and the Choroid-Bruch's Layer. Cheruvu, N.P., Kompella, U.B. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  28. Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro. Hermanns, M.I., Unger, R.E., Kehe, K., Peters, K., Kirkpatrick, C.J. Lab. Invest. (2004) [Pubmed]
  29. Evaluation of the dye-protein tracers in pathophysiology of the blood-brain barrier. Wolman, M., Klatzo, I., Chui, E., Wilmes, F., Nishimoto, K., Fujiwara, K., Spatz, M. Acta Neuropathol. (1981) [Pubmed]
  30. Flow cytometric detection of some activation and proliferation markers in human hematopoietic cell lines. Glasová, M., Koníková, E., Kusenda, J., Babusíková, O. Neoplasma (1996) [Pubmed]
  31. Polarized secretion of IL-6 by IEC-6 intestinal epithelial cells: differential effects of IL-1 beta and TNF-alpha. Mascarenhas, J.O., Goodrich, M.E., Eichelberger, H., McGee, D.W. Immunol. Invest. (1996) [Pubmed]
  32. Structural mechanisms of acute VEGF effect on microvessel permeability. Fu, B.M., Shen, S. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  33. Hemorheological effects of sodium fluorescein in rats. Sargento, L., Sobral do Rosário, H., Saldanha, C., Martins-Silva, J. Clin. Hemorheol. Microcirc. (2001) [Pubmed]
  34. Interleukin-1beta and barrier function of retinal pigment epithelial cells (ARPE-19): aberrant expression of junctional complex molecules. Abe, T., Sugano, E., Saigo, Y., Tamai, M. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  35. In situ measurement of solute transport in the bone lacunar-canalicular system. Wang, L., Wang, Y., Han, Y., Henderson, S.C., Majeska, R.J., Weinbaum, S., Schaffler, M.B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  36. Treatment with insulin-like growth factor I alters capillary permeability in skin and retina. Hussain, M.A., Studer, K., Messmer, E.P., Froesch, E.R. Diabetes (1995) [Pubmed]
  37. Vitreous fluorescein accumulation determined by in vivo fluorophotometry and by vitreous extraction in normal and diabetic rats. Kaufmann, F., Lacoste, C. Diabetologia (1986) [Pubmed]
  38. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Zhang, J., Benveniste, H., Klitzman, B., Piantadosi, C.A. Stroke (1995) [Pubmed]
  39. Effects of perfusion rate on permeability of frog and rat mesenteric microvessels to sodium fluorescein. Montermini, D., Winlove, C.P., Michel, C. J. Physiol. (Lond.) (2002) [Pubmed]
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