Chemical Compound Review:
Benzamil 3,5-diamino-N-(N'- benzylcarbamimidoyl)-6...
Synonyms:
GNF-Pf-192, Lopac-B-2417, CHEMBL212579, BSPBio_000693, BSPBio_001580, ...
- Intracellular calcium levels and calcium fluxes in the CA1 region of the rat hippocampal slice during in vitro ischemia: relationship to electrophysiological cell damage. Lobner, D., Lipton, P. J. Neurosci. (1993)
- Effects of topically delivered benzamil and amiloride on nasal potential difference in cystic fibrosis. Hofmann, T., Stutts, M.J., Ziersch, A., Rückes, C., Weber, W.M., Knowles, M.R., Lindemann, H., Boucher, R.C. Am. J. Respir. Crit. Care Med. (1998)
- Brain sodium channels and central sodium-induced increases in brain ouabain-like compound and blood pressure. Wang, H., Leenen, F.H. J. Hypertens. (2003)
- Benzamil, a blocker of epithelial Na(+) channel-induced upregulation of artery oxygen pressure level in acute lung injury rabbit ventilated with high frequency oscillation. Taguchi, N., Niisato, N., Sawabe, Y., Miyazaki, H., Hirai, Y., Marunaka, Y. Biochem. Biophys. Res. Commun. (2005)
- Putative role of epithelial sodium channels (ENaC) in the afferent limb of cardio renal reflexes in rats. Ditting, T., Linz, P., Hilgers, K.F., Jung, O., Geiger, H., Veelken, R. Basic Res. Cardiol. (2003)
- rENaC is the predominant Na+ channel in the apical membrane of the rat renal inner medullary collecting duct. Volk, K.A., Sigmund, R.D., Snyder, P.M., McDonald, F.J., Welsh, M.J., Stokes, J.B. J. Clin. Invest. (1995)
- The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning. Voilley, N., Lingueglia, E., Champigny, G., Mattéi, M.G., Waldmann, R., Lazdunski, M., Barbry, P. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger. Stys, P.K., Waxman, S.G., Ransom, B.R. J. Neurosci. (1992)
- Hyposecretion, not hyperabsorption, is the basic defect of cystic fibrosis airway glands. Joo, N.S., Irokawa, T., Robbins, R.C., Wine, J.J. J. Biol. Chem. (2006)
- Epithelial Na+ channels are activated by laminar shear stress. Carattino, M.D., Sheng, S., Kleyman, T.R. J. Biol. Chem. (2004)
- Intracellular Ca2+ mediates the cytotoxicity induced by bepridil and benzamil in human brain tumor cells. Lee, Y.S., Sayeed, M.M., Wurster, R.D. Cancer Lett. (1995)
- The effects of benzamil on in vitro contracture responses of human skeletal muscle to halothane. Hopkins, P.M., Ellis, F.R., Halsall, P.J. Gen. Pharmacol. (1994)
- Benzamil blockade of brain Na+ channels averts Na(+)-induced hypertension in rats. Nishimura, M., Ohtsuka, K., Nanbu, A., Takahashi, H., Yoshimura, M. Am. J. Physiol. (1998)
- Photoaffinity labeling of the epithelial sodium channel. Kleyman, T.R., Yulo, T., Ashbaugh, C., Landry, D., Cragoe, E., Karlin, A., Al-Awqati, Q. J. Biol. Chem. (1986)
- Biochemical evidence for the presence of an amiloride binding protein in adult alveolar type II pneumocytes. Oh, Y., Matalon, S., Kleyman, T.R., Benos, D.J. J. Biol. Chem. (1992)
- Polyvalent cations inhibit human neutrophil chemotaxis by interfering with the polymerization of actin. Simchowitz, L., Cragoe, E.J. J. Biol. Chem. (1990)
- Embryonic neuroepithelial sodium transport, the resulting physiological potential, and cranial development. Shi, R., Borgens, R.B. Dev. Biol. (1994)
- A new type of amiloride-sensitive cationic channel in endothelial cells of brain microvessels. Vigne, P., Champigny, G., Marsault, R., Barbry, P., Frelin, C., Lazdunski, M. J. Biol. Chem. (1989)
- High affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles. Desir, G.V., Cragoe, E.J., Aronson, P.S. J. Biol. Chem. (1991)
- Epithelial Na+ channel mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin. Auberson, M., Hoffmann-Pochon, N., Vandewalle, A., Kellenberger, S., Schild, L. Am. J. Physiol. Renal Physiol. (2003)
- A role for Na+/Ca2+ exchange in the generation of superoxide radicals by human neutrophils. Simchowitz, L., Foy, M.A., Cragoe, E.J. J. Biol. Chem. (1990)
- Regulation of aldosterone biosynthesis by Na+/H+ antiport: relationships between intracellular pH and angiotensin II. Horiuchi, T., Nguyen, T.T., Cragoe, E.J., De Léan, A. Endocrinology (1989)
- Kinetic properties of the K+/H+ antiport of heart mitochondria. Brierley, G.P., Jung, D.W. Biochemistry (1990)
- Vascular ENaC proteins are required for renal myogenic constriction. Jernigan, N.L., Drummond, H.A. Am. J. Physiol. Renal Physiol. (2005)
- Sodium channel but neither Na(+)-H+ nor Na-glucose symport inhibitors slow neonatal lung water clearance. O'Brodovich, H., Hannam, V., Rafii, B. Am. J. Respir. Cell Mol. Biol. (1991)
- Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network. Numata, M., Orlowski, J. J. Biol. Chem. (2001)
- Activation of transepithelial ion transport by secretin in human intestinal Caco-2 cells. Fukuda, M., Ohara, A., Bamba, T., Saek, Y. Jpn. J. Physiol. (2000)
- Ca2+ uptake by the endoplasmic reticulum Ca2+-ATPase in rat microvascular endothelial cells. Moccia, F., Berra-Romani, R., Baruffi, S., Spaggiari, S., Signorelli, S., Castelli, L., Magistretti, J., Taglietti, V., Tanzi, F. Biochem. J. (2002)
- Mechanisms of inactivation of the action of aldosterone on collecting duct by TGF-beta. Husted, R.F., Sigmund, R.D., Stokes, J.B. Am. J. Physiol. Renal Physiol. (2000)
- Direct inhibition of contractile apparatus by analogues of amiloride in the smooth muscle of guinea-pig taenia caecum and chicken gizzard. Ozaki, H., Moriyama, T., Karaki, H., Kohama, K., Cragoe, E.J. Biochem. Pharmacol. (1989)
- Location and function of the epithelial Na channel in the cochlea. Couloigner, V., Fay, M., Djelidi, S., Farman, N., Escoubet, B., Runembert, I., Sterkers, O., Friedlander, G., Ferrary, E. Am. J. Physiol. Renal Physiol. (2001)
- Block by amiloride and its derivatives of mechano-electrical transduction in outer hair cells of mouse cochlear cultures. Rüsch, A., Kros, C.J., Richardson, G.P. J. Physiol. (Lond.) (1994)
- Uncoupling histogenesis from morphogenesis in the vertebrate embryo by collapse of the transneural tube potential. Borgens, R.B., Shi, R. Dev. Dyn. (1995)
- Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI. Huang, B.S., Leenen, F.H. Am. J. Physiol. Heart Circ. Physiol. (2005)