Disease relevance of HSDB 1337

• Substrate selectivity of a 3-nitrophenol-induced metabolic system in Pseudomonas putida 2NP8 transforming nitroaromatic compounds into ammonia under aerobic conditions [1].
• 3-Hydroxylaminophenol mutase from Ralstonia eutropha JMP134 is involved in the degradative pathway of 3-nitrophenol, in which it catalyzes the conversion of 3-hydroxylaminophenol to aminohydroquinone [2].
• Glucose amendment (0.5%) to the culture medium of Chlorella vulgaris reversed the algal toxicity caused by p-nitrophenol (PNP) and m-nitrophenol (MNP), only at their algistatic levels [3].
• Concentration-dependent inhibition of the photosynthetic electron transport chain (photosystem I (PS I), photosystem II (PS II) and whole chain reaction) and ATP content was observed in Nostoc muscorum and Chlorella vulgaris grown with o-nitrophenol, m-nitrophenol, or 2,4-dinitrophenol [4].

High impact information on HSDB 1337

• The G103L isoform has enhanced selectivity for ortho hydroxylation with all substrates tested except nitrobenzene, which gives only m-nitrophenol [5].
• Based on these transformation products, we propose a new ammonia release pathway via oxidation of aminophenol to benzoquinone monoimine and subsequent hydrolysis for transformation of nitroaromatic compounds by 3-nitrophenol-grown cells of P. putida 2NP8 [6].
• Biotransformation products of hydroxylaminobenzene and aminophenol produced by 3-nitrophenol-grown cells of Pseudomonas putida 2NP8, a strain grown on 2- and 3-nitrophenol, were characterized [6].
• 3-Nitrophenol nitroreductase is active with a variety of mono-, di-, and trinitroaromatic compounds, demonstrating a relaxed substrate specificity of the enzyme [7].
• This catalytic support was used to degrade 3-nitrophenol (3-NP) using two different hydrogen donors (hydrogen gas and sodium formate) [8].

Chemical compound and disease context of HSDB 1337

• A strain of Pseudomonas putida (2NP8) capable of growing on both 2-nitrophenol and 3-nitrophenol, but not on nitrobenzene (NB), was isolated from municipal activated sludge [9].
• Degradation of 3-nitrophenol by Pseudomonas putida B2 occurs via 1,2,4-benzenetriol [10].

Associations of HSDB 1337 with other chemical compounds

• Interestingly, m-nitrophenol, known for its resistance to biodegradation because of meta substitution, was decomposed by Bacillus sp., resulting in the formation of nitrite and phenol; o-nitrophenol and 2,4-dinitrophenol resisted degradation by this bacterium [11].
• After exposure of benzene to synthesised peroxynitrite, phenol, nitrophenols (p-nitrophenol, o-nitrophenol and m-nitrophenol) and nitrobenzene were identified in the reaction mixture by HPLC separation and single UV wavelength and diode array detection [12].
• Determination of m-nitrophenol and nipecotic acid in mouse tissues by high-performance liquid chromatography after administration of the anticonvulsant m-nitrophenyl-3-piperidinecarboxylate hydrochloride [13].

Gene context of HSDB 1337

• The partial least squares regression method (PLS) was tested as a calibration procedure for the simultaneous determination of phenol, o-nitrophenol, m-nitrophenol and p-nitrophenol by both conventional and first derivative UV/Vis spectrophotometry [14].

References