Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Trh-gly 2-[[(2S)-1-[(2S)-3-(3H- imidazol-4-yl)-2...

Synonyms: TRH Glycine, AC1L3TMG, AC1Q5WML, Trh, gly, AR-1G9323, ...

Pekary, A.E. et al., Mori, M. et al., Pekary, A.E. et al., Pekary, A.E. et al., Fuse, Y. et al., et al.

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Psychiatry related information on Gly-thyrotropin-releasing hormone

A possible direct precursor of thyrotropin-releasing hormone, pGlu-His-Pro-Gly, stimulates prolactin secretion in anorexia nervosa [1].
The median eminence content of pGlu-His-Pro-Gly (TRH-Gly, a presumed immediate precursor of TRH), proTRH160-169 or TRH were not affected by food deprivation [2].

High impact information on Gly-thyrotropin-releasing hormone

TRH is produced from its possible direct precursor, pGlu-His-Pro-Gly (TRH-Gly), by alpha-amidating enzyme [1].
TRH and a TRH precursor peptide, TRH-Gly (pGlu-His-Pro-Gly), were measured in ventral prostates from 2-, 5-, and 18-month-old Fisher 344 male rats using a combination of HPLC and specific RIAs for TRH and TRH-Gly [3].
In the present study we have examined the in vivo effects of thyroid hormones and TRH on tissue and blood levels of TRH and TRH-Gly (pGlu-His-Pro-Gly), a TRH precursor [4].
Predominance of pGlu-His-Pro-Gly among all TRH precursor peptides in rat limbic forebrain after electroconvulsive seizures [5].

Anatomical context of Gly-thyrotropin-releasing hormone

A thyrotropin-releasing hormone (TRH) precursor peptide, pGlu-His-Pro-Gly (TRH-Gly) and related peptides were measured in human cerebrospinal fluid (CSF) with a TRH-Gly radiommunoassay and the levels of immunoreactivity (IR) were found to be 136- to 352-fold higher than the corresponding levels of TRH-IR [6].

Associations of Gly-thyrotropin-releasing hormone with other chemical compounds

Thyrotropin releasing hormone (TRH) and its precursor peptide pGlu-His-Pro-Gly (TRH-Gly) were measured in serum and in a variety of tissues of developing rats using specific RIA [7].

Analytical, diagnostic and therapeutic context of Gly-thyrotropin-releasing hormone

Because this last step in the biosynthesis of TRH is rate limiting for pGlu-His-Pro-Gly, we have combined several chromatographic and radioimmunoassay techniques to identify this TRH precursor in rat prostate [8].

References

A possible direct precursor of thyrotropin-releasing hormone, pGlu-His-Pro-Gly, stimulates prolactin secretion in anorexia nervosa. Mori, M., Murakami, M., Satoh, T., Miyashita, K., Iriuchijima, T., Yamada, M., Inukai, T., Kobayashi, I. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
Starvation-induced changes in the hypothalamic content of prothyrotrophin-releasing hormone (proTRH) mRNA and the hypothalamic release of proTRH-derived peptides: role of the adrenal gland. van Haasteren, G.A., Linkels, E., Klootwijk, W., van Toor, H., Rondeel, J.M., Themmen, A.P., de Jong, F.H., Valentijn, K., Vaudry, H., Bauer, K. J. Endocrinol. (1995) [Pubmed]
Thyrotropin-releasing hormone (TRH)-Gly conversion to TRH in rat ventral prostate is inhibited by castration and aging. Pekary, A.E., Knoble, M., Garcia, N. Endocrinology (1989) [Pubmed]
Thyroid hormone modulation of TRH precursor levels in rat hypothalamus, pituitary, thyroid and blood. Simard, M., Pekary, A.E., Smith, V.P., Hershman, J.M. Peptides (1989) [Pubmed]
Predominance of pGlu-His-Pro-Gly among all TRH precursor peptides in rat limbic forebrain after electroconvulsive seizures. Pekary, A.E., Lloyd, R.L., Sattin, A. Ann. N. Y. Acad. Sci. (1994) [Pubmed]
High levels of thyrotropin-releasing hormone precursor peptide immunoreactivity and binding substance occur in human cerebrospinal fluid. Pekary, A.E., Gwirtsman, H., Tourtellotte, W.W., Smith, V.P., Hershman, J.M. Neuroendocrinology (1991) [Pubmed]
Ontogeny of thyrotropin releasing hormone and precursor peptide in the rat. Fuse, Y., Polk, D.H., Lam, R.W., Fisher, D.A. Pediatr. Res. (1991) [Pubmed]
Evidence for thyrotropin-releasing hormone (TRH) biosynthesis in rat prostate. Pekary, A.E., Reeve, J.R., Smith, V.P. Life Sci. (1986) [Pubmed]

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