Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Egta-AME 2- [acetyloxymethoxycarbonylmethy l-[2-[2-[2...

Synonyms: Egta-am, EGTA/AM, AG-I-02053, AC1L3TMJ, AR-1H0518, ...

Viráģ, L. et al., Mineharu, A. et al., Naidu, P.S. et al.

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High impact information on Egta-AME

Inhibition of this early calcium signaling by cell-permeable Ca(2+) chelators [EGTA-acetoxymethyl ester (AM), 1, 2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid-AM (BAPTA-AM), 8-amino-2-[(2-amino-5-methylphenoxy)methyl]-6-methoxyquinoline-N,N , N',N'-tetraacetic acid-tetra-AM] abolished cytotoxicity as measured by propidium iodide uptake [1].
(iii) The administration of a Ca(2+) chelator, EGTA-acetoxymethyl ester (AM, 0.3 mM), to the endolymph, which produced a gradual increase in EP, suppressed significantly, by 60-80%, DeltaEP(asp) or furosemide-induced changes in EP [2].
Treatment of cells with the intracellular calcium chelator EGTA-acetoxymethyl ester inhibited BK-stimulated MAPK activation, suggesting that intracellular calcium mobilization contributes to the activation of MAPK [3].

References

Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity. Viráģ, L., Scott, G.S., Antal-Szalmás, P., O'Connor, M., Ohshima, H., Szabó, C. Mol. Pharmacol. (1999) [Pubmed]
Endolymphatic perfusion with EGTA-acetoxymethyl ester inhibits asphyxia- and furosemide-induced decrease in endocochlear potential in guinea pigs. Mineharu, A., Mori, Y., Nimura, Y., Takamaki, A., Araki, M., Yamaji, J., Yoshida, R., Takenaka, H., Kubota, T. Jpn. J. Physiol. (2005) [Pubmed]
Calcium-calmodulin mediates bradykinin-induced MAPK phosphorylation and c-fos induction in vascular cells. Naidu, P.S., Velarde, V., Kappler, C.S., Young, R.C., Mayfield, R.K., Jaffa, A.A. Am. J. Physiol. (1999) [Pubmed]

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