Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL275313 1-azabicyclo[2.2.2]oct-8-yl 2-hydroxy-2-(4...

Synonyms: AR-1C1575, AC1L3U8P, AC1Q4PI1, 1-Ahip, 4-Iqnb, ...

Piggott, M.A. et al., Eckelman, W.C. et al., Holman, B.L. et al.

Piggott, Owens, O'Brien, Colloby, Fenwick, Wyper, Jaros, Johnson, Perry, Perry,

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Psychiatry related information on 4-Iqnb

Muscarinic acetylcholine receptors in Alzheimer's disease. In vivo imaging with iodine 123-labeled 3-quinuclidinyl-4-iodobenzilate and emission tomography [1].
Derivatives of the muscarinic antagonist 3-quinuclidinyl-4-iodobenzilate (QNB), particularly [123I]-(R,R)-I-QNB, are currently being assessed as in vivo ligands to monitor muscarinic receptors in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), relating changes to disease symptoms and to treatment response with cholinergic medication [2].

High impact information on 4-Iqnb

3-Quinuclidinyl 4-iodobenzilate was shown to bind to the muscarinic acetylcholine receptor (mAChR) by testing the saturability and the stereoselectivity in the corpus striatum, cerebellum, and the heart [3].

References

Muscarinic acetylcholine receptors in Alzheimer's disease. In vivo imaging with iodine 123-labeled 3-quinuclidinyl-4-iodobenzilate and emission tomography. Holman, B.L., Gibson, R.E., Hill, T.C., Eckelman, W.C., Albert, M., Reba, R.C. JAMA (1985) [Pubmed]
Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease. Piggott, M.A., Owens, J., O'Brien, J., Colloby, S., Fenwick, J., Wyper, D., Jaros, E., Johnson, M., Perry, R.H., Perry, E.K. J. Chem. Neuroanat. (2003) [Pubmed]
Use of 3-quinuclidinyl 4-iodobenzilate as a receptor binding radiotracer. Eckelman, W.C., Eng, R., Rzeszotarski, W.J., Gibson, R.E., Francis, B., Reba, R.C. J. Nucl. Med. (1985) [Pubmed]

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