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Chemical Compound Review

AC1L3XLV     1-[(2R,3R,4S,5R)-5- [[[[(2R,3R,4R,5R)-5-(6...

Synonyms: 5502-96-5, Nicotinate adenine dinucleotide phosphate, Nicotinic acid adenine dinucleotide phosphate
This record was replaced with 123953.
 
 
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High impact information on C13051

  • Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP [1].
  • Cells were significantly more sensitive to NAADP than to either cADPR or InsP3, whereas higher concentrations of NAADP selectively inactivated CCK-evoked Ca2+ signals in pancreatic acinar cells, indicating that NAADP may function as an intracellular messenger in mammalian cells [2].
  • Recent investigations of the action of the brain-gut peptide cholecystokinin on pancreatic acinar cells have indicated that NAADP and cADPR receptors are essential for Ca2+ release [3].
  • The nuclear envelope contains ryanodine and IP3 receptors that can be activated separately and independently; the ryanodine receptors by either NAADP or cADPR, and the IP3 receptors by IP3 [4].
  • Nicotinic acid adenine dinucleotide phosphate (NAADP(+)) is an essential regulator of T-lymphocyte Ca(2+)-signaling [5].
 

Biological context of C13051

  • Here, we provide pharmacological evidence demonstrating that endocytosis is crucial for the generation of repetitive local Ca(2+) spikes evoked by the agonists and by NAADP and IP(3) [6].
  • Acidic Residues at the Active Sites of CD38 and ADP-ribosyl Cyclase Determine Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthesis and Hydrolysis Activities [7].
  • Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand [8].
  • Nicotinic acid adenine dinucleotide phosphate (NAADP) has recently been shown to act as a second messenger controlling intracellular Ca(2+) responses in mammalian cells [9].
  • Our results suggest that a lysosome-mediated Ca2+ regulatory mechanism via NAADP contributes to ET-1-induced Ca2+ mobilization in CASMCs and consequent vasoconstriction of coronary arteries [10].
 

Anatomical context of C13051

 

Associations of C13051 with other chemical compounds

 

Gene context of C13051

 

Analytical, diagnostic and therapeutic context of C13051

  • Jurkat T cell clones with largely reduced expression of ryanodine receptors did not respond to microinjections of NAADP [17].
  • HPLC assay showed that NAADP was produced in coronary arterial smooth muscle cells (CASMCs) via endogenous ADP-ribosyl cyclase [10].
  • In this study, we have employed Ca2+ imaging and the single-electrode voltage-clamp technique to investigate whether the NAADP-mediated Ca2+ entry discovered in our laboratory in starfish oocytes was underlain by a membrane current and whether the response to NAADP required an intact cytoskeleton [18].

References

  1. Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP. Lee, H.C. Physiol. Rev. (1997) [Pubmed]
  2. Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells. Cancela, J.M., Churchill, G.C., Galione, A. Nature (1999) [Pubmed]
  3. New Ca2+-releasing messengers: are they important in the nervous system? Petersen, O.H., Cancela, J.M. Trends Neurosci. (1999) [Pubmed]
  4. NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. Gerasimenko, J.V., Maruyama, Y., Yano, K., Dolman, N.J., Tepikin, A.V., Petersen, O.H., Gerasimenko, O.V. J. Cell Biol. (2003) [Pubmed]
  5. Nicotinic acid adenine dinucleotide phosphate (NAADP(+)) is an essential regulator of T-lymphocyte Ca(2+)-signaling. Berg, I., Potter, B.V., Mayr, G.W., Guse, A.H. J. Cell Biol. (2000) [Pubmed]
  6. Generation of specific ca(2+) signals from ca(2+) stores and endocytosis by differential coupling to messengers. Menteyne, A., Burdakov, A., Charpentier, G., Petersen, O.H., Cancela, J.M. Curr. Biol. (2006) [Pubmed]
  7. Acidic Residues at the Active Sites of CD38 and ADP-ribosyl Cyclase Determine Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthesis and Hydrolysis Activities. Graeff, R., Liu, Q., Kriksunov, I.A., Hao, Q., Lee, H.C. J. Biol. Chem. (2006) [Pubmed]
  8. Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand. Patel, S., Churchill, G.C., Galione, A. Biochem. J. (2000) [Pubmed]
  9. NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells. Soares, S., Thompson, M., White, T., Isbell, A., Yamasaki, M., Prakash, Y., Lund, F.E., Galione, A., Chini, E.N. Am. J. Physiol., Cell Physiol. (2007) [Pubmed]
  10. Production of NAADP and its role in Ca2+ mobilization associated with lysosomes in coronary arterial myocytes. Zhang, F., Zhang, G., Zhang, A.Y., Koeberl, M.J., Wallander, E., Li, P.L. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  11. NAADP receptors are present and functional in the heart. Bak, J., Billington, R.A., Timar, G., Dutton, A.C., Genazzani, A.A. Curr. Biol. (2001) [Pubmed]
  12. Suppressed insulin signaling and increased apoptosis in CD38-null islets. Johnson, J.D., Ford, E.L., Bernal-Mizrachi, E., Kusser, K.L., Luciani, D.S., Han, Z., Tran, H., Randall, T.D., Lund, F.E., Polonsky, K.S. Diabetes (2006) [Pubmed]
  13. InsP3, but not novel Ca2+ releasers, contributes to agonist-initiated contraction in rabbit airway smooth muscle. Iizuka, K., Yoshii, A., Dobashi, K., Horie, T., Mori, M., Nakazawa, T. J. Physiol. (Lond.) (1998) [Pubmed]
  14. Nicotinic acid adenine dinucleotide phosphate (NAADP) is present at micromolar concentrations in sea urchin spermatozoa. Billington, R.A., Ho, A., Genazzani, A.A. J. Physiol. (Lond.) (2002) [Pubmed]
  15. Specific Ca2+ signaling evoked by cholecystokinin and acetylcholine: the roles of NAADP, cADPR, and IP3. Cancela, J.M. Annu. Rev. Physiol. (2001) [Pubmed]
  16. Characterization of NAADP(+) binding in sea urchin eggs. Billington, R.A., Genazzani, A.A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  17. Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes. Dammermann, W., Guse, A.H. J. Biol. Chem. (2005) [Pubmed]
  18. NAADP activates a Ca2+ current that is dependent on F-actin cytoskeleton. Moccia, F., Lim, D., Nusco, G.A., Ercolano, E., Santella, L. FASEB J. (2003) [Pubmed]
 
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