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Chemical Compound Review

G(Anh)mtetra     6-[[4-[2-[2-[2-acetamido-4- [3-acetamido-4...

Synonyms: AC1Q5SCS, AR-1G4898, AC1L3YW1, A833491, Disaccharide tetrapeptide
 
 
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Disease relevance of Disaccharide tetrapeptide

 

High impact information on Disaccharide tetrapeptide

  • Furthermore, maximal G(Anh)MTetra-induced IL-1 beta and IL-6 mRNA expression could be enhanced by co-stimulation with LPS or MDP, suggesting that different receptors and/or transduction pathways were involved [3].
  • G(Anh)MTetra, a natural bacterial cell wall breakdown product, induces interleukin-1 beta and interleukin-6 expression in human monocytes. A study of the molecular mechanisms involved in inflammatory cytokine expression [3].
  • Experiments with the protein synthesis inhibitor cycloheximide revealed that G(Anh)MTetra-induced G-CSF mRNA expression was independent of new protein synthesis [5].
 

Anatomical context of Disaccharide tetrapeptide

 

Gene context of Disaccharide tetrapeptide

  • G(Anh)MTetra was found to strongly induce interleukin (IL)-1 beta and IL-6 mRNA expression after 2 h and IL-1 beta and IL-6 protein secretion after 48 h of activation [3].

References

  1. A structure-activity relationship for induction of meningeal inflammation by muramyl peptides. Burroughs, M., Rozdzinski, E., Geelen, S., Tuomanen, E. J. Clin. Invest. (1993) [Pubmed]
  2. Bordetella pertussis tracheal cytotoxin and other muramyl peptides: distinct structure-activity relationships for respiratory epithelial cytopathology. Luker, K.E., Collier, J.L., Kolodziej, E.W., Marshall, G.R., Goldman, W.E. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. G(Anh)MTetra, a natural bacterial cell wall breakdown product, induces interleukin-1 beta and interleukin-6 expression in human monocytes. A study of the molecular mechanisms involved in inflammatory cytokine expression. Dokter, W.H., Dijkstra, A.J., Koopmans, S.B., Stulp, B.K., Keck, W., Halie, M.R., Vellenga, E. J. Biol. Chem. (1994) [Pubmed]
  4. Tracheal cytotoxin structural requirements for respiratory epithelial damage in pertussis. Luker, K.E., Tyler, A.N., Marshall, G.R., Goldman, W.E. Mol. Microbiol. (1995) [Pubmed]
  5. G(AnH)MTetra, a naturally occurring 1,6-anhydro muramyl dipeptide, induces granulocyte colony-stimulating factor expression in human monocytes: a molecular analysis. Dokter, W.H., Dijkstra, A.J., Koopmans, S.B., Mulder, A.B., Stulp, B.K., Halie, M.R., Keck, W., Vellenga, E. Infect. Immun. (1994) [Pubmed]
 
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