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Chemical Compound Review

Mexate     (2S)-2-[[4-[(2,4- diaminopteridin-6...

Synonyms: Emtexate, Emthexat, Lantarel, Metolate, Metrotex, ...
 
 
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Disease relevance of methotrexate

 

Psychiatry related information on methotrexate

 

High impact information on methotrexate

 

Chemical compound and disease context of methotrexate

 

Biological context of methotrexate

 

Anatomical context of methotrexate

  • A similar organization is found in independently isolated methotrexate-resistant cell lines, in the parental sensitive cell line and in several inbred mouse strains, indicating that this organization represents that of the natural gene [29].
  • Among patients with increased risk, radiation offered greater protection to the central nervous system than methotrexate (P = 0.03); there was no difference in the rate of hematologic relapse [30].
  • RESULTS: Recipients of cord blood were younger than recipients of bone marrow (median age, 5 years vs. 8 years; P<0.001), weighed less (median weight, 17 kg vs. 26 kg; P<0.001), and were less likely to have received methotrexate for prophylaxis against GVHD (28 percent vs. 65 percent, P<0.001) [31].
  • Letter: Methotrexate in cerebrospinal fluid [32].
  • These variables, as well as the grip strength and erythrocyte sedimentation rate, showed significant (P less than 0.01) improvement at 24 weeks in the population crossed over to methotrexate [33].
 

Associations of methotrexate with other chemical compounds

 

Gene context of methotrexate

 

Analytical, diagnostic and therapeutic context of methotrexate

References

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  4. Brief report: reversible lymphomas associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis. Kamel, O.W., van de Rijn, M., Weiss, L.M., Del Zoppo, G.J., Hench, P.K., Robbins, B.A., Montgomery, P.G., Warnke, R.A., Dorfman, R.F. N. Engl. J. Med. (1993) [Pubmed]
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  12. Low-dose methotrexate therapy for ocular inflammatory disease. Shah, S.S., Lowder, C.Y., Schmitt, M.A., Wilke, W.S., Kosmorsky, G.S., Meisler, D.M. Ophthalmology (1992) [Pubmed]
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  20. A randomized clinical trial evaluating sequential methotrexate and fluorouracil in the treatment of patients with node-negative breast cancer who have estrogen-receptor-negative tumors. Fisher, B., Redmond, C., Dimitrov, N.V., Bowman, D., Legault-Poisson, S., Wickerham, D.L., Wolmark, N., Fisher, E.R., Margolese, R., Sutherland, C. N. Engl. J. Med. (1989) [Pubmed]
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  23. Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia. Evans, W.E., Relling, M.V., Rodman, J.H., Crom, W.R., Boyett, J.M., Pui, C.H. N. Engl. J. Med. (1998) [Pubmed]
  24. Memantine protects rats treated with intrathecal methotrexate from developing spatial memory deficits. Cole, P.D., Vijayanathan, V., Ali, N.F., Wagshul, M.E., Tanenbaum, E.J., Price, J., Dalal, V., Gulinello, M.E. Clin. Cancer Res. (2013) [Pubmed]
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  27. Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group. Giannini, E.H., Brewer, E.J., Kuzmina, N., Shaikov, A., Maximov, A., Vorontsov, I., Fink, C.W., Newman, A.J., Cassidy, J.T., Zemel, L.S. N. Engl. J. Med. (1992) [Pubmed]
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  30. Comparison of intermediate-dose methotrexate with cranial irradiation for the post-induction treatment of acute lymphocytic leukemia in children. Freeman, A.I., Weinberg, V., Brecher, M.L., Jones, B., Glicksman, A.S., Sinks, L.F., Weil, M., Pleuss, H., Hananian, J., Burgert, E.O., Gilchrist, G.S., Necheles, T., Harris, M., Kung, F., Patterson, R.B., Maurer, H., Leventhal, B., Chevalier, L., Forman, E., Holland, J.F. N. Engl. J. Med. (1983) [Pubmed]
  31. Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources. Rocha, V., Wagner, J.E., Sobocinski, K.A., Klein, J.P., Zhang, M.J., Horowitz, M.M., Gluckman, E. N. Engl. J. Med. (2000) [Pubmed]
  32. Letter: Methotrexate in cerebrospinal fluid. Zweig, M. N. Engl. J. Med. (1976) [Pubmed]
  33. Efficacy of low-dose methotrexate in rheumatoid arthritis. Weinblatt, M.E., Coblyn, J.S., Fox, D.A., Fraser, P.A., Holdsworth, D.E., Glass, D.N., Trentham, D.E. N. Engl. J. Med. (1985) [Pubmed]
  34. Cyclosporine and methotrexate for severe rheumatoid arthritis. Steinberg, A.D. N. Engl. J. Med. (1995) [Pubmed]
  35. Replication initiates in a broad zone in the amplified CHO dihydrofolate reductase domain. Vaughn, J.P., Dijkwel, P.A., Hamlin, J.L. Cell (1990) [Pubmed]
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  37. Extended follow-up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation. Cutler, C., Li, S., Ho, V.T., Koreth, J., Alyea, E., Soiffer, R.J., Antin, J.H. Blood (2007) [Pubmed]
  38. Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line. Hochhauser, D., Schnieders, B., Ercikan-Abali, E., Gorlick, R., Muise-Helmericks, R., Li, W.W., Fan, J., Banerjee, D., Bertino, J.R. J. Natl. Cancer Inst. (1996) [Pubmed]
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