Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

RB 38A (2S)-2-[[(2R)-2-benzyl-3...

Synonyms: RB 38 A, AC1L2V25, 105831-46-7

Tejedor-Real, P. et al., Maldonado, R. et al., Maldonado, R. et al.

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Disease relevance of RB 38 A

Lacrimation and weight loss were reduced by kelatorphan and RB 38 A whereas teeth chattering, tremor, eye twitch and rhinorrhea were decreased only by RB 38 A. The rise in plasma corticosterone levels was only slightly reduced by the three inhibitors [1].

Psychiatry related information on RB 38 A

The antidepressant-like effects induced by RB 38B, and especially by RB 38A, in the learned helplessness paradigm suggest that new mixed enkephalinase inhibitors, able to cross the blood-brain barrier, could provide a new strategy in the treatment of affective disorders [2].

High impact information on RB 38 A

Chronic i.c.v. administration of DAGO, DSTBULET and RB 38 A produced a time-dependent reduction in analgesia, but 120 h after continuous infusion only RB 38 A was able to still induce a significative antinociceptive effect [3].

References

Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter. Maldonado, R., Fournié-Zaluski, M.C., Roques, B.P. Naunyn Schmiedebergs Arch. Pharmacol. (1992) [Pubmed]
Effect of mixed (RB 38A) and selective (RB 38B) inhibitors of enkephalin degrading enzymes on a model of depression in the rat. Tejedor-Real, P., Micó, J.A., Maldonado, R., Roques, B.P., Gibert-Rahola, J. Biol. Psychiatry (1993) [Pubmed]
Differences in physical dependence induced by selective mu or delta opioid agonists and by endogenous enkephalins protected by peptidase inhibitors. Maldonado, R., Feger, J., Fournié-Zaluski, M.C., Roques, B.P. Brain Res. (1990) [Pubmed]

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