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Chemical Compound Review

Ethylnitrosourea     1-ethyl-1-nitroso-urea

Synonyms: Aenh, NE-Urea, CCRIS 302, CHEMBL167667, AG-H-02971, ...
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Disease relevance of N-Ethyl-N-nitrosourea


Psychiatry related information on N-Ethyl-N-nitrosourea

  • A small fraction of the animals develop B and T cell lymphomas after a long latency period, but the incidence is dramatically enhanced following administration of N-ethyl-N-nitrosourea, a carcinogen that induces DNA mutations [6].
  • Using the alkaline filter elution technique we determined the induction and disappearance of DNA single-strand breaks (SSB) in freshly isolated peripheral blood lymphocytes (PBL) from 43 Alzheimer's disease (AD) patients and 48 normal, healthy age- and sex-matched control subjects following in vitro exposure to N-ethyl-N-nitrosourea (ENU) [7].

High impact information on N-Ethyl-N-nitrosourea

  • Other mutations, induced by the random germ line mutagen ENU (N-ethyl-N-nitrosourea), have disclosed key molecules in the TLR signaling pathways and helped us to construct a reasonably sophisticated portrait of the afferent innate immune response [8].
  • Here, we report the identification of a hyperactive N-ethyl-N-nitrosourea (ENU)-induced mouse mutant with abnormalities in the laminar architecture of the hippocampus and cortex, accompanied by impaired neuronal migration [9].
  • ABL-1 does not antagonize germline apoptosis induced by the DNA-alkylating agent ethylnitrosourea [10].
  • Conventional germ-cell mutagenesis with N-ethyl-N-nitrosourea (ENU) is compromised by an inability to monitor mutation efficiency, strain and interlocus variation in mutation induction, and extensive husbandry requirements [11].
  • Phenotype-driven approaches using the chemical mutagen ethylnitrosourea (ENU) represent a potentially efficient route for the generation of large numbers of mutant mice that can be screened for novel phenotypes [12].

Chemical compound and disease context of N-Ethyl-N-nitrosourea


Biological context of N-Ethyl-N-nitrosourea


Anatomical context of N-Ethyl-N-nitrosourea


Associations of N-Ethyl-N-nitrosourea with other chemical compounds


Gene context of N-Ethyl-N-nitrosourea


Analytical, diagnostic and therapeutic context of N-Ethyl-N-nitrosourea


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