Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL444589 4-(amino-carboxy-methyl)-2- hydroxy-benzoic...

Synonyms: CHEBI:242988, AR-1F9801, LS-172885, C9H9NO5, AC1L1B5Z, ...

Battaglia, G. et al., Manzoni, O. et al., D'Onofrio, M. et al.

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Disease relevance of 134052-66-7

The mGlu2/3 receptor agonists 4-carboxy-3-hydroxyphenylglycine (4C3HPG) and LY379268 attenuated NMDA toxicity in primary cultures containing both neurons and astrocytes [1].

High impact information on 134052-66-7

Some metabotropic glutamate receptor (mGluR) ligands, such as quisqualate, L-(+)-2-amino-4-phosphonobutyric acid (L-AP4), 4-carboxy-3-hydroxyphenylglycine (4C3HPG), and L-serine-O:-phosphate (L-SOP), reduced the formation of the endogenous excitatory amino acid receptor antagonist kynurenate in brain and liver slices [2].
Two selective agonists of group 2 mGluRs, (2S,1's,2's)-2-(2'-carboxycyclopropyl)glycine and 4-carboxy-3-hydroxyphenylglycine, were totally ineffective in blocking CA3-CA1-evoked synaptic transmission, excluding the involvement of mGluR2/3 subtypes at this developmental stage [3].

References

Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways. D'Onofrio, M., Cuomo, L., Battaglia, G., Ngomba, R.T., Storto, M., Kingston, A.E., Orzi, F., De Blasi, A., Di Iorio, P., Nicoletti, F., Bruno, V. J. Neurochem. (2001) [Pubmed]
Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II. Battaglia, G., Rassoulpour, A., Wu, H.Q., Hodgkins, P.S., Kiss, C., Nicoletti, F., Schwarcz, R. J. Neurochem. (2000) [Pubmed]
Metabotropic glutamate receptors inhibiting excitatory synapses in the CA1 area of rat hippocampus. Manzoni, O., Bockaert, J. Eur. J. Neurosci. (1995) [Pubmed]

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