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Chemical Compound Review

Favistan     1-methyl-3H-imidazole-2-thione

Synonyms: Mercazol, Methizol, Tapazole, Thimazol, Thyrozol, ...
 
 
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Disease relevance of Strumazol

 

Psychiatry related information on Strumazol

 

High impact information on Strumazol

 

Chemical compound and disease context of Strumazol

 

Biological context of Strumazol

 

Anatomical context of Strumazol

 

Associations of Strumazol with other chemical compounds

 

Gene context of Strumazol

  • Activity studies were done with two selective functional FMO substrates, methimazole, and 10-(N,N-dimethylaminopentyl)-2-(trifluoromethyl)phenothiazine and exon 3- (exon 4 for FMO4) deleted FMOs were not able to catalyze the S- and N-oxygenation of these substrates, respectively [30].
  • Methimazole (MMI) and PTU had similar potencies in inhibiting the TPO-catalyzed coupling reaction, whereas MMI was distinctly more potent than PTU as an inhibitor of TPO-mediated iodination in vitro [31].
  • In addition, serum anti-TSH receptor antibody levels were directly correlated with the absolute numbers of T cells bound to IL-2 (r = 0.565, P < 0.05) and to IL-6 (r = 0.653), P = 0.02) in the hyperthyroid untreated patients, but not in long-term remission euthyroid GD patients or in patients treated with methimazole [32].
  • Following antithyroid drug treatment with methimazole, GH responses to GHRH increased in these patients in comparison to pretreatment values [33].
  • Our results show that methimazole therapy downregulates the abnormally high expression of the CD69 early activation antigen on T cells, being less effective on inducing changes in other T cell activation markers and in NK cells [34].
 

Analytical, diagnostic and therapeutic context of Strumazol

References

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  17. Oxidative decarboxylation of free and peptide-linked amino acids in phagocytizing guinea pig granulocytes. Adeniyi-Jones, S.K., Karnovsky, M.L. J. Clin. Invest. (1981) [Pubmed]
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  19. Modulation by the thyroid state of intracellular calcium and contractility in ferret ventricular muscle. MacKinnon, R., Gwathmey, J.K., Allen, P.D., Briggs, G.M., Morgan, J.P. Circ. Res. (1988) [Pubmed]
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  22. Phenyl methimazole inhibits TNF-alpha-induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and reduces monocytic cell adhesion to endothelial cells. Dagia, N.M., Harii, N., Meli, A.E., Sun, X., Lewis, C.J., Kohn, L.D., Goetz, D.J. J. Immunol. (2004) [Pubmed]
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  24. Treatment of methimazole-induced agranulocytosis using recombinant human granulocyte colony-stimulating factor (rhG-CSF). Tamai, H., Mukuta, T., Matsubayashi, S., Fukata, S., Komaki, G., Kuma, K., Kumagai, L.F., Nagataki, S. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  25. Identification and characterization of novel genes modulated in the thyroid of dogs treated with methimazole and propylthiouracil. Wilkin, F., Savonet, V., Radulescu, A., Petermans, J., Dumont, J.E., Maenhaut, C. J. Biol. Chem. (1996) [Pubmed]
  26. Thyroid hormone stimulation of NADPH P450 reductase expression in liver and extrahepatic tissues. Regulation by multiple mechanisms. Ram, P.A., Waxman, D.J. J. Biol. Chem. (1992) [Pubmed]
  27. Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. Magnusson, R.P., Taurog, A., Dorris, M.L. J. Biol. Chem. (1984) [Pubmed]
  28. Reactions of purified hog thyroid peroxidase with H2O2, tyrosine, and methylmercaptoimidazole (goitrogen) in comparison with bovine lactoperoxidase. Ohtaki, S., Nakagawa, H., Nakamura, M., Yamazaki, I. J. Biol. Chem. (1982) [Pubmed]
  29. Iodide binding and regulation of lactoperoxidase activity toward thyroid goitrogens. Michot, J.L., Nunez, J., Johnson, M.L., Irace, G., Edelhoch, H. J. Biol. Chem. (1979) [Pubmed]
  30. Alternative processing events in human FMO genes. Lattard, V., Zhang, J., Cashman, J.R. Mol. Pharmacol. (2004) [Pubmed]
  31. Coupling of iodotyrosine catalyzed by human thyroid peroxidase in vitro. Sugawara, M. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  32. Analysis of IL-2 and IL-6 binding to peripheral blood lymphocytes in Graves disease: relationship with disease activity. Corrales, J.J., Orfao, A., López, A., Mories, M.T., Miralles, J.M., Ciudad, J. Cytometry. (1997) [Pubmed]
  33. Influence of hyperthyroidism on growth hormone secretion. Valcavi, R., Dieguez, C., Zini, M., Muruais, C., Casanueva, F., Portioli, I. Clin. Endocrinol. (Oxf) (1993) [Pubmed]
  34. Methimazole therapy in Graves' disease influences the abnormal expression of CD69 (early activation antigen) on T cells. Corrales, J.J., López, A., Ciudad, J., Mories, M.T., Miralles, J.M., Orfao, A. J. Endocrinol. (1997) [Pubmed]
  35. Frequency of antineutrophil cytoplasmic antibody in Graves' disease patients treated with methimazole. Gumà, M., Salinas, I., Reverter, J.L., Roca, J., Valls-Roc, M., Juan, M., Olivé, A. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  36. Enhanced activity of the purine nucleotide cycle of the exercising muscle in patients with hyperthyroidism. Fukui, H., Taniguchi , S., Ueta, Y., Yoshida, A., Ohtahara, A., Hisatome, I., Shigemasa, C. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  37. Arterial embolization: a novel approach to thyroid ablative therapy for Graves' disease. Xiao, H., Zhuang, W., Wang, S., Yu, B., Chen, G., Zhou, M., Wong, N.C. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  38. Methimazole has no dose-related effect on the intensity of the intrathyroidal autoimmune process in relapsing Graves' disease. Paschke, R., Vogg, M., Kristoferitsch, R., Aktuna, D., Wawschinek, O., Eber, O., Usadel, K.H. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  39. Methimazole pharmacology in man: studies using a newly developed radioimmunoassay for methimazole. Cooper, D.S., Bode, H.H., Nath, B., Saxe, V., Maloof, F., Ridgway, E.C. J. Clin. Endocrinol. Metab. (1984) [Pubmed]
 
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