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Chemical Compound Review

Aloesin     7-hydroxy-5-methyl-2-(2- oxopropyl)-8-[(2R...

Synonyms: Aloeresin B, Aloersin B, SureCN6936841, Aloe resin B, AC1Q5CGK, ...
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Disease relevance of Aloersin B


High impact information on Aloersin B

  • Aloeresin I (1) (1 micromol/cm2) reduces in vivo the oedematous response (39 %) induced by Croton oil in the mouse ear with the same potency as aloesin, one of the most abundant Cape aloe constituents, and to a higher extent than aloeresin H (2) [4].
  • Aloesin inhibits purified tyrosinase enzyme and specifically inhibits melanin production in vitro [5].
  • Tyrosine hydroxylase and 3,4-dihydroxyphenylalanine (DOPA) oxidase activities of tyrosinase from normal human melanocyte cell lysates were inhibited by aloesin in a dose dependent manner [5].
  • Enzyme kinetics studies using normal human melanocyte cell lysates and cell-based melanin production demonstrated that aloesin is a competitive inhibitor of tyrosinase from mushroom, human and murine sources [5].
  • As A. vera has long been used to promote wound healing, the inhibitory effects of aloesin derivatives for cyclooxygenase (Cox)-2 and thromboxane (Tx) A 2 synthase were examined and the participation of p-coumaroyl and feruloyl ester groups in the aloesin skeleton was demonstrated [6].

Biological context of Aloersin B


Associations of Aloersin B with other chemical compounds

  • Instead of aloin, other aloe compounds (e.g., aloeresin A or aloesin) should perhaps be used as an index of the presence of aloe in alcoholic beverages [8].
  • Taken together, we suggest that aloesin along with arbutin inhibits in synergy melanin production by combined mechanisms of noncompetitive and competitive inhibitions of tyrosinase activity [9].

Gene context of Aloersin B

  • In addition, immuno-complex kinase assays showed that aloesin up-regulated the enzyme activity of cyclin E/CDK2 kinase in a dose-dependent manner [3].
  • The data showed that aloesin increased the levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells [3].

Analytical, diagnostic and therapeutic context of Aloersin B


  1. Effects of aloe, aloesin, or propolis on the pharmacokinetics of benzo[a]pyrene and 3-OH-benzo[a]pyrene in rats. Cao, D., Yoon, C.H., Shin, B.S., Kim, C.H., Park, E.S., Yoo, S.D. J. Toxicol. Environ. Health Part A (2005) [Pubmed]
  2. Aloesin inhibits hyperpigmentation induced by UV radiation. Choi, S., Lee, S.K., Kim, J.E., Chung, M.H., Park, Y.I. Clin. Exp. Dermatol. (2002) [Pubmed]
  3. Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells. Lee, K.Y., Park, J.H., Chung, M.H., Park, Y.I., Kim, K.W., Lee, Y.J., Lee, S.K. Biochem. Mol. Biol. Int. (1997) [Pubmed]
  4. Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe. Speranza, G., Morelli, C.F., Tubaro, A., Altinier, G., Durì, L., Manitto, P. Planta Med. (2005) [Pubmed]
  5. Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase. Jones, K., Hughes, J., Hong, M., Jia, Q., Orndorff, S. Pigment Cell Res. (2002) [Pubmed]
  6. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Yagi, A., Kabash, A., Okamura, N., Haraguchi, H., Moustafa, S.M., Khalifa, T.I. Planta Med. (2002) [Pubmed]
  7. Inhibition of mushroom-tyrosinase by aloe extract. Yagi, A., Kanbara, T., Morinobu, N. Planta Med. (1987) [Pubmed]
  8. High-performance liquid chromatographic profiles of aloe constituents and determination of aloin in beverages, with reference to the EEC regulation for flavouring substances. Zonta, F., Bogoni, P., Masotti, P., Micali, G. Journal of chromatography. A. (1995) [Pubmed]
  9. Aloesin and arbutin inhibit tyrosinase activity in a synergistic manner via a different action mechanism. Jin, Y.H., Lee, S.J., Chung, M.H., Park, J.H., Park, Y.I., Cho, T.H., Lee, S.K. Arch. Pharm. Res. (1999) [Pubmed]
  10. Determination of aloesin in plasma by high-performance liquid chromatography. Kim, M.J., Shin, W.G. Res. Commun. Mol. Pathol. Pharmacol. (1998) [Pubmed]
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