Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL423835 2-[1-methoxy-1-[3- (naphthalen-2...

Synonyms: AG-K-34131, CHEBI:126053, ICI-211965, DNC013991, AR-1L6670, ...

Crawley, G.C. et al., Falgueyret, J.P. et al.

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High impact information on ZM 211965

Investigation of the SAR of the lead (methoxyalkyl)thiazole 1-[3-(naphth-2-ylmethoxy)phenyl]-1-thiazol-2-ylprop yl methyl ether (1, ICI 211965) led to the methoxytetrahydropyrans, a new series of 5-lipoxygenase (5-LPO) inhibitors exemplified by the parent compound 4-[3-(naphth-2-ylmethoxy)phenyl]-4- methoxy-3,4,5,6-tetrahydro-2H-pyran (4f) [1].
These three observations with ICI 211965 and L-689,065 are in contrast to the behavior of other potent 5-lipoxygenase inhibitors from other structural classes, such as L-670,630, BW A4C, and zileuton, which all function as reducing substrates for 5-lipoxygenase [2].

References

Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors. Crawley, G.C., Dowell, R.I., Edwards, P.N., Foster, S.J., McMillan, R.M., Walker, E.R., Waterson, D., Bird, T.G., Bruneau, P., Giroaeau, J.M. J. Med. Chem. (1992) [Pubmed]
Criteria for the identification of non-redox inhibitors of 5-lipoxygenase. Falgueyret, J.P., Hutchinson, J.H., Riendeau, D. Biochem. Pharmacol. (1993) [Pubmed]

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