Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Lnfp II N-[(2R,3R,4R,5S,6R)-2- [(2R,3S,4S,5R,6R)-3...

Synonyms: Lea penta, LNF II, HMDB06577, AC1L5118, 21973-23-9, ...

Larsen, E. et al., Mårtensson, S. et al., Lamerz, R., Gnoth, M.J. et al.

Lamerz,

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Disease relevance of Lnfp II

For biliopancreatic malignancy, following CEA as more historical and basic TM of gastrointestinal diseases, the mainstay marker is CA 19-9 as monosialo-ganglioside/glycolipid and sialyl derivative of lacto-N-fucopentaose II (sialyl-Lewis(a), hapten of human Lewis(a) bloodgroup determinant) [1].

High impact information on Lnfp II

The CD15 antigen, lacto-N-fucopentaose III (Gal beta 1----4[Fuc alpha 1----3]NAcGlc beta 1----3Gal-beta 1----4Glc), inhibited the interaction of neutrophils or HL60 cells with platelets, whereas lacto-N-fucopentaose I did not; lacto-N-fucopentaose II demonstrated minimal inhibition [2].
However, the Lea-active oligosaccharide hapten, lacto-N-fucopentaose II, with the same carbohydrate structure, fails to inhibit binding of 43-9F, and a well-characterized anti-Lea monoclonal antibody blocks only 40% of 43-9F binding sites on SLC cells, suggesting that the major epitope recognized by 43-9F is more complex than the Lea epitope [3].
Furthermore, the uptake of lacto-N-fucopentaose I could be inhibited by the addition of the stereoisomer lacto-N-fucopentaose II but not by lacto-N-tetraose [4].

References

Role of tumour markers, cytogenetics. Lamerz, R. Ann. Oncol. (1999) [Pubmed]
PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15). Larsen, E., Palabrica, T., Sajer, S., Gilbert, G.E., Wagner, D.D., Furie, B.C., Furie, B. Cell (1990) [Pubmed]
A carbohydrate epitope associated with human squamous lung cancer. Mårtensson, S., Due, C., Påhlsson, P., Nilsson, B., Eriksson, H., Zopf, D., Olsson, L., Lundblad, A. Cancer Res. (1988) [Pubmed]
Investigations of the in vitro transport of human milk oligosaccharides by a Caco-2 monolayer using a novel high performance liquid chromatography-mass spectrometry technique. Gnoth, M.J., Rudloff, S., Kunz, C., Kinne, R.K. J. Biol. Chem. (2001) [Pubmed]

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