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Chemical Compound Review

INDICAN     potassium 3-sulfonatooxy-1H-indole

Synonyms:
 
 
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Disease relevance of INDICAN

 

Psychiatry related information on INDICAN

  • When Id and NaS were ingested together, the bladder mass increase was additive, but the epithelial hyperplasia was not exacerbated over that observed with each alone, and the urinary indican was equivalent to that produced by Id alone [2].
 

High impact information on INDICAN

  • Dietary soybean trypsin inhibitor in the dose range of 17-713 mg/100 g diet was associated with parallel dose-dependent increases in urinary indican and pancreatic acinar cell size (assessed histologically) [1].
  • These findings suggest that a high level of urinary indican excretion is associated with an increase in bladder mass and epithelial hyperplasia (Id treatment) but indicate that the relatively low urinary indican level obtained by NaS feeding alone is unlikely to be responsible for the bladder responses noted with this compound [2].
  • Establishment of the gut flora in pups at weaning in the presence of saccharin was associated with increased caecal size and caecal protein, decreased caecal tryptophanase activity, and increased urine volume and urinary indican excretion [5].
  • Effect of lactobacilli on urinary indican excretion in gnotobiotic rats and in man [3].
  • Urinary indican as a screening index of jejunal bacterial flora in Indian adulthood cirrhosis [6].
 

Anatomical context of INDICAN

 

Associations of INDICAN with other chemical compounds

  • Tests of intestinal function included blood xylose and iron absorption curves, a double isotope Schilling test, faecal fat, urinary indican and small bowel radiology, with duodenal aspiration and jejunal biopsy in some cases [8].
 

Analytical, diagnostic and therapeutic context of INDICAN

  • Intestinal protein metabolism and bile acid deconjugation (measured by urinary indican excretion and 14C-glycocholic acid breath test) was significantly enhanced in bypass patients [9].

References

  1. Trypsin inhibitor ingestion-induced urinary indican excretion and pancreatic acinar cell hypertrophy. Anderson, R.L., Maurer, J.K., Francis, W.R., Buring, S.L. Nutrition and cancer. (1986) [Pubmed]
  2. Comparison of the bladder response to indole and sodium saccharin ingestion by male rats. Anderson, R.L., Lefever, F.R., Miller, N.S., Maurer, J.K. Food Chem. Toxicol. (1989) [Pubmed]
  3. Effect of lactobacilli on urinary indican excretion in gnotobiotic rats and in man. Tohyama, K., Kobayashi, Y., Kan, T., Yazawa, K., Terashima, T., Mutai, M. Microbiol. Immunol. (1981) [Pubmed]
  4. Urinary indican excretion in cirrhosis of liver. Patney, N.L., Mehrotra, M.P., Khanna, H.K., Kumar, A. The Journal of the Association of Physicians of India. (1976) [Pubmed]
  5. The microbial metabolism of tryptophan in rats fed a diet containing 7.5% saccharin in a two-generation protocol. Sims, J., Renwick, A.G. Food Chem. Toxicol. (1985) [Pubmed]
  6. Urinary indican as a screening index of jejunal bacterial flora in Indian adulthood cirrhosis. Patney, N.L., Mehrotra, M.P., Khanna, H.K., Goyal, S.P., Kumar, A. Indian journal of medical sciences. (1979) [Pubmed]
  7. The role of urinary indican as a predictor of bacterial colonization in the human jejunum. Mayer, P.J., Beeken, W.L. The American journal of digestive diseases. (1975) [Pubmed]
  8. The ageing gut: a study of intestinal absorption in relation to nutrition in the elderly. Montgomery, R.D., Haeney, M.R., Ross, I.N., Sammons, H.G., Barford, A.V., Balakrishnan, S., Mayer, P.P., Culank, L.S., Field, J., Gosling, P. Q. J. Med. (1978) [Pubmed]
  9. Intestinal bacterial metabolism of protein and bile acids: role in pathogenesis of hepatic disease after jejuno-ileal bypass surgery. Powell-Jackson, P.R., Maudgal, D.P., Sharp, D., Goldie, A., Maxwell, J.D. The British journal of surgery. (1979) [Pubmed]
 
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