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Chemical Compound Review

AGN-PC-00JB7A     [5-(6-aminopurin-9-yl)-2- [[[[3-[2-(2...

Synonyms: A7925_SIGMA, AR-1H5727, AC1L18NR, AC1Q68Z5, 72-89-9, ...
 
 
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Disease relevance of acetyl-CoA

  • Thus, acetylcoenzyme A binding to type II E. coli citrate synthase would require substantial structural shifts and a concerted refolding of the polypeptide chain to form an appropriate binding subsite [1].
  • These data suggest that acetylator genotype-dependent expression of AcCoA-dependent N-acetyltransferase activity in extrahepatic tissues may play an important role in hereditary predisposition to toxicity and/or carcinogenesis in extrahepatic organs following exposure to arylamine drugs and foreign chemicals [2].
 

High impact information on acetyl-CoA

  • RbAp48 lowered the K(m) of CBP histone acetylase activity and facilitated p300-mediated in vitro transcription of a chromatinized template in the presence of acetylcoenzyme A [3].
  • We report the molecular cloning and sequence of the cDNA coding for the biotin-containing subunit of the chloroplastic acetylcoenzyme A (CoA) carboxylase (ACCase) of Arabidopsis thaliana (CAC1) [4].
  • The contribution of exogenous acetate to acetylcoenzyme A was nearly equal in skeletal muscle and heart in vivo (83-87%, measured in tissue extracts), comparable with earlier perfused heart studies in which acetate was the sole available substrate [5].
  • The inhibition of ChA by both alpha- and beta-NETA was noncompetitive with acetylcoenzyme A or choline as the variable substrate [6].
  • However, the reduction in the enzymatic affinity constant and its smaller change following in vitro stimulation suggest that alterations in the affinity of acetyltransferase for acetylcoenzyme A (CoA) and in the regulation of enzyme activity may be occurring during acute asthma [7].
 

Biological context of acetyl-CoA

 

Anatomical context of acetyl-CoA

 

Associations of acetyl-CoA with other chemical compounds

 

Gene context of acetyl-CoA

 

Analytical, diagnostic and therapeutic context of acetyl-CoA

References

  1. Comparative analysis of folding and substrate binding sites between regulated hexameric type II citrate synthases and unregulated dimeric type I enzymes. Nguyen, N.T., Maurus, R., Stokell, D.J., Ayed, A., Duckworth, H.W., Brayer, G.D. Biochemistry (2001) [Pubmed]
  2. Extrahepatic expression of N-acetylator genotype in the inbred hamster. Hein, D.W., Kirlin, W.G., Ogolla, F., Trinidad, A. Drug Metab. Dispos. (1987) [Pubmed]
  3. Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB. Zhang, Q., Vo, N., Goodman, R.H. Mol. Cell. Biol. (2000) [Pubmed]
  4. Molecular cloning and characterization of the cDNA coding for the biotin-containing subunit of the chloroplastic acetyl-coenzyme A carboxylase. Choi, J.K., Yu, F., Wurtele, E.S., Nikolau, B.J. Plant Physiol. (1995) [Pubmed]
  5. Oxidation of acetate in rabbit skeletal muscle: detection by 13C NMR spectroscopy in vivo. Szczepaniak, L., Babcock, E.E., Malloy, C.R., Sherry, A.D. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1996) [Pubmed]
  6. 2-(alpha-Naphthoyl)ethyltrimethylammonium iodide and its beta-isomer: new selective, stable and fluorescent inhibitors of choline acetyltransferase. Sastry, B.V., Jaiswal, N., Owens, L.K., Janson, V.E., Moore, R.D. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  7. Lyso-PAF acetyltransferase activity in neutrophils of patients during acute asthma and after recovery. Misso, N.L., Gillon, R.L., Stewart, G.A., Thompson, P.J. Eur. Respir. J. (1996) [Pubmed]
  8. Mechanisms of toxicity, clinical features, and management of acute chlorophenoxy herbicide poisoning: a review. Bradberry, S.M., Watt, B.E., Proudfoot, A.T., Vale, J.A. J. Toxicol. Clin. Toxicol. (2000) [Pubmed]
  9. Nourseothricin (streptothricin) inactivated by a plasmid pIE636 encoded acetyl transferase of Escherichia coli: location of the acetyl group. Zähringer, U., Voigt, W., Seltmann, G. FEMS Microbiol. Lett. (1993) [Pubmed]
  10. Partial purification and characterization of histidine acetyltransferase in brain of Nile tilapia (Oreochromis niloticus). Yamada, S., Tanaka, Y., Furuichi, M. Biochim. Biophys. Acta (1995) [Pubmed]
  11. Utilization of volatile fatty acide in ruminants. IV. Purification of acetylcoenzyme A synthetase from mitochondria of lactating goat mammary gland. Cook, R.M., Simon, S., Ricks, C.A. J. Agric. Food Chem. (1975) [Pubmed]
  12. Effect of the source of dietary fat on postweaning lipogenesis in lean and fat pigs. Freire, J.P., Mourot, J., Cunha, L.F., Almeida, J.A., Aumaitre, A. Ann. Nutr. Metab. (1998) [Pubmed]
  13. Acetylcoenzyme A and the synthesis of acetylcholine in neurones: review of recent progress. Tucek, S. Gen. Physiol. Biophys. (1983) [Pubmed]
  14. Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells. Libby, P.R., Ganis, B., Bergeron, R.J., Porter, C.W. Arch. Biochem. Biophys. (1991) [Pubmed]
  15. Molecular evidence for the aerobic expression of nifJ, encoding pyruvate:ferredoxin oxidoreductase, in cyanobacteria. Schmitz, O., Gurke, J., Bothe, H. FEMS Microbiol. Lett. (2001) [Pubmed]
  16. Characterization of Bradyrhizobium japonicum pcaBDC genes involved in 4-hydroxybenzoate degradation. Lorite, M.J., Sanjuan, J., Velasco, L., Olivares, J., Bedmar, E.J. Biochim. Biophys. Acta (1998) [Pubmed]
  17. Direct inhibition of choline acetyltransferase activity by a monoclonal antibody raised against the plasma membrane of cholinergic nerve terminals. Eder-Colli, L., Froment, Y., Monsurro, M.R. Brain Res. (1989) [Pubmed]
  18. Purification and characterization of acetylcoenzyme A: deacetylvindoline 4-O-acetyltransferase from Catharanthus roseus. Power, R., Kurz, W.G., De Luca, V. Arch. Biochem. Biophys. (1990) [Pubmed]
  19. 1(2-benzoylethyl)pyridinium chloride: a new potent and selective inhibitor of bovine brain and human placental choline acetyltransferase. Choudhuri, M.S., Chaturvedi, A.K. Brain Res. Bull. (1991) [Pubmed]
  20. Dietary protein source affects lipid metabolism in the European seabass (Dicentrarchus labrax). Dias, J., Alvarez, M.J., Arzel, J., Corraze, G., Diez, A., Bautista, J.M., Kaushik, S.J. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2005) [Pubmed]
  21. Immobilization of acetylcoenzyme A synthetase and the preparation of an enzyme reactor for the synthesis of [11C]acetylcoenzyme A. Mannens, G., Slegers, G., Lambrecht, R., Claeys, A. Biochim. Biophys. Acta (1988) [Pubmed]
 
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