Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L51A4 (4S)-4-[[(1S)-2- aminocarbonyl-1-[[(2S)-6...

Synonyms: 80887-44-1, Neurotensin (1-8), Pglu-leu-tyr-glu-asn-lys-pro-arg

Lee, Y.C. et al., Castel, M.N. et al., Lee, Y.C. et al., McDermott, J.R. et al., Chen, L. et al., et al.

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High impact information on Pglu-leu-tyr-glu-asn-lys-pro-arg

The depolarizing effect of neurotensin could be mimicked by the C-terminal fragment, neurotensin (8-13), but not by the N-terminal fragment, neurotensin (1-8) [1].
Both gel filtration and reversed phase high-pressure liquid chromatography (HPLC) showed that the main degradation product of neurotensin in human plasma in vitro was chromatographically and immunologically identical to neurotensin 1-8 and HPLC also demonstrated the formation of neurotensin 1-11 [2].

Anatomical context of Pglu-leu-tyr-glu-asn-lys-pro-arg

Neurotensin 1-8 and NT 8-13 inhibited gastric acid secretion only at 144 pmol/kg per h, while the analogue Phe11-NT had no effect [3].

Associations of Pglu-leu-tyr-glu-asn-lys-pro-arg with other chemical compounds

Neurotensin is cleaved at Arg8-Arg9, Pro10-Tyr11 and Ile12-Leu13, giving neurotensin (1-8), neurotensin (1-10), neurotensin (1-12) and neurotensin (9-13) as major products [4].

Gene context of Pglu-leu-tyr-glu-asn-lys-pro-arg

The appearance of this labelling was prevented by injection of a large excess of unlabelled neurotensin or of neurotensin 8-13, an active neurotensin fragment, but not by neurotensin 1-8 which had no affinity for neurotensin receptors [5].

Analytical, diagnostic and therapeutic context of Pglu-leu-tyr-glu-asn-lys-pro-arg

Intact neurotensin and the N-terminal metabolic fragment, neurotensin 1-8, were quantified by radioimmunoassay with C- and N-terminally directed antisera in conjunction with gel filtration of plasma samples obtained at timed intervals [6].

References

Neurotensin depolarizes globus pallidus neurons in rats via neurotensin type-1 receptor. Chen, L., Yung, K.K., Yung, W.H. Neuroscience (2004) [Pubmed]
In vitro degradation of neurotensin in human plasma. Lee, Y.C., Uttenthal, L.O., Smith, H.A., Bloom, S.R. Peptides (1986) [Pubmed]
Effect of neurotensin and neurotensin fragments on gastric acid secretion in man. Holst Pedersen, J., Skov Olsen, P., Kirkegaard, P. Regul. Pept. (1986) [Pubmed]
Mechanism of degradation of LH-RH and neurotensin by synaptosomal peptidases. McDermott, J.R., Smith, A.I., Dodd, P.R., Hardy, J.A., Edwardson, J.A. Peptides (1983) [Pubmed]
Retrograde axonal transport of neurotensin in rat nigrostriatal dopaminergic neurons. Modulation during ageing and possible physiological role. Castel, M.N., Beaudet, A., Laduron, P.M. Biochem. Pharmacol. (1994) [Pubmed]
Quantitation and characterization of human plasma neurotensin-like immunoreactivity in response to a meal. Lee, Y.C., Allen, J.M., Uttenthal, L.O., Roberts, P.M., Gill, S.S., Bloom, S.R. Dig. Dis. Sci. (1985) [Pubmed]

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