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Chemical Compound Review

Aciclovir     2-amino-9-(2- hydroxyethoxymethyl)-3H- purin...

Synonyms: Activir, Virolex, Zovirax, acyclovir, Avirax, ...
 
 
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Disease relevance of Vipral

 

Psychiatry related information on Vipral

 

High impact information on Vipral

 

Chemical compound and disease context of Vipral

 

Biological context of Vipral

 

Anatomical context of Vipral

 

Associations of Vipral with other chemical compounds

  • We conclude that acyclovir is better than vidarabine for the treatment of varicella-zoster infection in immunocompromised patients [28].
  • Thus, we conducted a controlled trial comparing long-term administration of ganciclovir with high-dose acyclovir for prevention of CMV infection and disease in liver transplant recipients [29].
  • The 3.3-kbp BamHI fragment containing most of the DNA polymerase gene from isolate 615.8 was purified and used to successfully transfer both acyclovir and foscarnet resistance [30].
  • Time to total crusting and healing was accelerated for patients receiving acyclovir plus prednisone compared with patients receiving two placebos; the risk ratios were 2.27 (95% Cl, 1.46 to 3.55) for total crusting and 2.07 (Cl, 1.26 to 3.38) for healing [31].
  • The resultant 100-fold increase in the ratio of the concentrations of acyclovir triphosphate to dGTP should facilitate the binding of the fraudulent nucleotide to its target enzyme, herpes virus-encoded DNA polymerase, and could account for the synergy between A1110U and acyclovir [32].
  • Mitochondrial toxicity is relatively low because acyclovir is activated only in infected cells by the promiscuous viral thymidine kinase and otherwise, mitochondrial toxicity would accumulate during long term treatment [33].
 

Gene context of Vipral

 

Analytical, diagnostic and therapeutic context of Vipral

References

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  5. Vidarabine versus acyclovir therapy in herpes simplex encephalitis. Whitley, R.J., Alford, C.A., Hirsch, M.S., Schooley, R.T., Luby, J.P., Aoki, F.Y., Hanley, D., Nahmias, A.J., Soong, S.J. N. Engl. J. Med. (1986) [Pubmed]
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  8. Hepatic veno-occlusive disease--liver toxicity syndrome after bone marrow transplantation. Shulman, H.M., Hinterberger, W. Bone Marrow Transplant. (1992) [Pubmed]
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  13. A randomized trial of acyclovir for 7 days or 21 days with and without prednisolone for treatment of acute herpes zoster. Wood, M.J., Johnson, R.W., McKendrick, M.W., Taylor, J., Mandal, B.K., Crooks, J. N. Engl. J. Med. (1994) [Pubmed]
  14. A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection. Infectious Diseases Collaborative Antiviral Study Group. Whitley, R., Arvin, A., Prober, C., Burchett, S., Corey, L., Powell, D., Plotkin, S., Starr, S., Alford, C., Connor, J. N. Engl. J. Med. (1991) [Pubmed]
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  16. A controlled trial comparing foscarnet with vidarabine for acyclovir-resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. Safrin, S., Crumpacker, C., Chatis, P., Davis, R., Hafner, R., Rush, J., Kessler, H.A., Landry, B., Mills, J. N. Engl. J. Med. (1991) [Pubmed]
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  18. Acyclovir treatment of the chronic fatigue syndrome. Lack of efficacy in a placebo-controlled trial. Straus, S.E., Dale, J.K., Tobi, M., Lawley, T., Preble, O., Blaese, R.M., Hallahan, C., Henle, W. N. Engl. J. Med. (1988) [Pubmed]
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  20. Suppression of frequently recurring genital herpes. A placebo-controlled double-blind trial of oral acyclovir. Straus, S.E., Takiff, H.E., Seidlin, M., Bachrach, S., Lininger, L., DiGiovanna, J.J., Western, K.A., Smith, H.A., Lehrman, S.N., Creagh-Kirk, T. N. Engl. J. Med. (1984) [Pubmed]
  21. Possible drug interaction during therapy with azidothymidine and acyclovir for AIDS. Bach, M.C. N. Engl. J. Med. (1987) [Pubmed]
  22. Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance. Darby, G., Field, H.J., Salisbury, S.A. Nature (1981) [Pubmed]
  23. Prophylactic acyclovir in patients receiving bone marrow transplants. Trigg, M.E., Finlay, J.L., Sondel, P.M. N. Engl. J. Med. (1985) [Pubmed]
  24. Epstein-Barr virus-induced B-cell lymphoma after renal transplantation: acyclovir therapy and transition from polyclonal to monoclonal B-cell proliferation. Hanto, D.W., Frizzera, G., Gajl-Peczalska, K.J., Sakamoto, K., Purtilo, D.T., Balfour, H.H., Simmons, R.L., Najarian, J.S. N. Engl. J. Med. (1982) [Pubmed]
  25. A randomized, placebo-controlled trial of oral acyclovir for the prevention of cytomegalovirus disease in recipients of renal allografts. Balfour, H.H., Chace, B.A., Stapleton, J.T., Simmons, R.L., Fryd, D.S. N. Engl. J. Med. (1989) [Pubmed]
  26. Herpes simplex virus infection of human fibroblasts and keratinocytes inhibits recognition by cloned CD8+ cytotoxic T lymphocytes. Koelle, D.M., Tigges, M.A., Burke, R.L., Symington, F.W., Riddell, S.R., Abbo, H., Corey, L. J. Clin. Invest. (1993) [Pubmed]
  27. Drugs five years later: acyclovir. Dorsky, D.I., Crumpacker, C.S. Ann. Intern. Med. (1987) [Pubmed]
  28. Treatment of varicella-zoster virus infection in severely immunocompromised patients. A randomized comparison of acyclovir and vidarabine. Shepp, D.H., Dandliker, P.S., Meyers, J.D. N. Engl. J. Med. (1986) [Pubmed]
  29. Randomised comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients. Winston, D.J., Wirin, D., Shaked, A., Busuttil, R.W. Lancet (1995) [Pubmed]
  30. Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Sacks, S.L., Wanklin, R.J., Reece, D.E., Hicks, K.A., Tyler, K.L., Coen, D.M. Ann. Intern. Med. (1989) [Pubmed]
  31. Acyclovir with and without prednisone for the treatment of herpes zoster. A randomized, placebo-controlled trial. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Whitley, R.J., Weiss, H., Gnann, J.W., Tyring, S., Mertz, G.J., Pappas, P.G., Schleupner, C.J., Hayden, F., Wolf, J., Soong, S.J. Ann. Intern. Med. (1996) [Pubmed]
  32. 2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir. Spector, T., Harrington, J.A., Morrison, R.W., Lambe, C.U., Nelson, D.J., Averett, D.R., Biron, K., Furman, P.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  33. Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity. Hanes, J.W., Zhu, Y., Parris, D.S., Johnson, K.A. J. Biol. Chem. (2007) [Pubmed]
  34. Inhibition of tumor growth by direct intratumoral gene transfer of herpes simplex virus thymidine kinase gene with DNA-liposome complexes. Sugaya, S., Fujita, K., Kikuchi, A., Ueda, H., Takakuwa, K., Kodama, S., Tanaka, K. Hum. Gene Ther. (1996) [Pubmed]
  35. Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters. Landowski, C.P., Sun, D., Foster, D.R., Menon, S.S., Barnett, J.L., Welage, L.S., Ramachandran, C., Amidon, G.L. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  36. Inhibitory effects of IFN-gamma and acyclovir on the glioblastoma cell cycle. Kominsky, S.L., Subramaniam, P.S., Johnson, H.M., Torres, B.A. J. Interferon Cytokine Res. (2000) [Pubmed]
  37. Identification and analysis of the simian varicella virus thymidine kinase gene. Pumphrey, C.Y., Gray, W.L. Arch. Virol. (1996) [Pubmed]
  38. Adenovirus-mediated suicide-gene therapy using the herpes simplex virus thymidine kinase gene in cell and animal models of human prostate cancer: changes in tumour cell proliferative activity. Cheon, J., Kim, H.K., Moon, D.G., Yoon, D.K., Cho, J.H., Koh, S.K. BJU international. (2000) [Pubmed]
  39. Acyclovir for prevention of cytomegalovirus infection and disease after allogeneic marrow transplantation. Meyers, J.D., Reed, E.C., Shepp, D.H., Thornquist, M., Dandliker, P.S., Vicary, C.A., Flournoy, N., Kirk, L.E., Kersey, J.H., Thomas, E.D. N. Engl. J. Med. (1988) [Pubmed]
  40. Persistence of immunity to varicella in children with leukemia immunized with live attenuated varicella vaccine. Gershon, A.A., Steinberg, S.P. N. Engl. J. Med. (1989) [Pubmed]
  41. A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. Douglas, J.M., Critchlow, C., Benedetti, J., Mertz, G.J., Connor, J.D., Hintz, M.A., Fahnlander, A., Remington, M., Winter, C., Corey, L. N. Engl. J. Med. (1984) [Pubmed]
 
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