Chemical Compound Review:
CHEMBL279433 4-[[5-[[4-(3-chlorophenyl)-3- oxo-piperazin...
Synonyms:
AG-K-24107, SureCN1683541, CHEBI:129948, CTK7C7787, DNC003581, ...
- A phase I and pharmacological study of the farnesyl protein transferase inhibitor L-778,123 in patients with solid malignancies. Britten, C.D., Rowinsky, E.K., Soignet, S., Patnaik, A., Yao, S.L., Deutsch, P., Lee, Y., Lobell, R.B., Mazina, K.E., McCreery, H., Pezzuli, S., Spriggs, D. Clin. Cancer Res. (2001)
- A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer. Martin, N.E., Brunner, T.B., Kiel, K.D., DeLaney, T.F., Regine, W.F., Mohiuddin, M., Rosato, E.F., Haller, D.G., Stevenson, J.P., Smith, D., Pramanik, B., Tepper, J., Tanaka, W.K., Morrison, B., Deutsch, P., Gupta, A.K., Muschel, R.J., McKenna, W.G., Bernhard, E.J., Hahn, S.M. Clin. Cancer Res. (2004)
- A Phase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer. Hahn, S.M., Bernhard, E.J., Regine, W., Mohiuddin, M., Haller, D.G., Stevenson, J.P., Smith, D., Pramanik, B., Tepper, J., DeLaney, T.F., Kiel, K.D., Morrison, B., Deutsch, P., Muschel, R.J., McKenna, W.G. Clin. Cancer Res. (2002)
- Inhibition of lymphocyte activation and function by the prenylation inhibitor L-778,123. Si, M.S., Reitz, B.A., Borie, D.C. Investigational new drugs. (2005)
- Farnesyl transferase inhibitors: a major breakthrough in anticancer therapy? Naples, 12 April 2002. Caponigro, F. Anticancer Drugs (2002)
- Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf. Zhang, Z., Wang, Y., Lantry, L.E., Kastens, E., Liu, G., Hamilton, A.D., Sebti, S.M., Lubet, R.A., You, M. Oncogene (2003)
- Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes. Reid, T.S., Long, S.B., Beese, L.S. Biochemistry (2004)
- The effects of the farnesyl transferase inhibitor FTI L-778,123 on normal, myelodysplastic, and myeloid leukemia bone marrow progenitor proliferation in vitro. Huang, X.K., Meyer, P., Li, B., Raza, A., Preisler, H.D. Leuk. Lymphoma (2003)
- Farnesyl transferase inhibitors for patients with lung cancer. Johnson, B.E., Heymach, J.V. Clin. Cancer Res. (2004)
- High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123. Buser, C.A., Dinsmore, C.J., Fernandes, C., Greenberg, I., Hamilton, K., Mosser, S.D., Walsh, E.S., Williams, T.M., Koblan, K.S. Anal. Biochem. (2001)
- American Association for Cancer Research 1999: 10-14 April, Philadelphia, Pennsylvania. Lavelle, F. Expert opinion on investigational drugs. (1999)