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Chemical Compound Review

Ara-AMP     [5-(6-aminopurin-9-yl)-3,4- dihydroxy...

Synonyms: AGN-PC-00YJ7D, SureCN144997, ACMC-209mq0, CHEBI:117144, NSC-127223, ...
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Disease relevance of Adenosine monophosphate

  • To investigate this possibility and to define the mechanism of defective hormone action, we measured the adenylate cyclase-stimulating bioactivity (B) and receptor-binding (R) activity of purified immunoreactive serum thyrotropin (I) from seven patients with hypothalamic hypothyroidism [1].
  • A similar apparent anomaly is seen with pertussis toxin, which has been shown to inhibit the Gi subunit of adenylate cyclase, and has a greater effect on cAMP accumulation and lipolysis than the activation by cholera toxin of the Gs subunit [2].
  • The essential change appears to be an hypertrophy of the cyclic AMP system, in response to inhibition by opiate of a neuronal adenylate cyclase [3].
  • EF, a calmodulin- and Ca2+-dependent adenylate cyclase, is responsible for the edema seen in the disease [4].
  • Parathyroid hormone-responsive adenylate cyclase in induced transplantable osteogenic rat sarcoma [5].

Psychiatry related information on Adenosine monophosphate


High impact information on Adenosine monophosphate

  • On medullary adenylate cyclase of pig kidney, the relation between receptor occupancy and enzyme activation was found to be complex and nonlinear [11].
  • A sharp decrease in the poly(A) chain growth rate after the addition of approximately 200 adenylate residues invites speculations about a role of the poly(A)-binding protein in poly(A) tail length control [12].
  • Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy [13].
  • The enhancement of adenylate cyclase activity requires protein kinase C (PKC) activation, indicating cross-talk between these two signal transduction pathways [14].
  • We also compared these two groups in terms of the inhibition of platelet monoamine oxidase activity by ethanol in vitro (400 mM), and in terms of the stimulation of adenylate cyclase activity by various agents [15].

Chemical compound and disease context of Adenosine monophosphate


Biological context of Adenosine monophosphate

  • These phosphorylation changes also occur when cAMP-induced activation of adenylate cyclase is blocked by pretreatment of amebas with caffeine [21].
  • Earlier studies, and further evidence presented here, show that there is no satisfactory correlation between the sudden adjustment of RNA accumulation and the kinetics of changes in the levels of prospective signalling compounds, such as glycolytic intermediates, ppGpp, ATP, or the three adenylate nucleotides [22].
  • This novel combination of imprecise termination of transcription or "sizing" of transcripts, and variable addition of adenylate residues, is discussed with regard to the mechanism of expression of the mammalian mitochondrial ribosomal RNA genes [23].
  • These results indicate that the beta-adrenergic receptor polypeptide contains both the ligand binding site and the site responsible for mediating stimulation of adenylate cyclase activity, presumably via interaction with the guanine nucleotide regulatory protein [24].
  • Arginine vasopressin receptors are G protein-coupled and have been divided into at least three types; the V1a (vascular/hepatic) and V1b (anterior pituitary) receptors which act through phosphatidylinositol hydrolysis to mobilize intracellular Ca2+, and the V2 (kidney) receptor which is coupled to adenylate cyclase [25].

Anatomical context of Adenosine monophosphate


Associations of Adenosine monophosphate with other chemical compounds


Gene context of Adenosine monophosphate

  • The extent to which selected peptides can inhibit adenylate cyclase through the Y5 receptor and stimulate food intake in rats correspond well [36].
  • The pituitary adenylate cyclase-activating polypeptide (PACAP)/ glucagon superfamily includes nine hormones in humans that are related by structure, distribution (especially the brain and gut), function (often by activation of cAMP), and receptors (a subset of seven-transmembrane receptors) [37].
  • The expressed hCTR was coupled to adenylate cyclase [38].
  • As predicted by in vivo studies, cotransfection of Neurofibromatosis Factor 1 significantly improves coupling of PDFR to adenylate cyclase. pdfr mutant flies display increased circadian arrhythmicity, and also display altered geotaxis that is epistatic to that of pdf mutants [39].
  • The amino acid sequence deduced from an open reading frame identified as the pseT gene contains a sequence which corresponds particularly well with that part of the adenine nucleotide binding site of adenylate kinase shown to form a flexible loop [40].

Analytical, diagnostic and therapeutic context of Adenosine monophosphate

  • Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase [41].
  • Since both beta receptors and cholera toxin-stimulated adenylate cyclase activities are present in C6/B104 cocultures, we conclude that the beta receptor/adenylate cyclase transduction mechanism in cocultured C6 cells is uncoupled [17].
  • Addition of choleragen to rat pineal organ cultures caused a long-lasting stimulation of adenylate cyclase activity, and this was followed by increases in seroton N-acetyltransferase and cyclic adenosine monophosphate phosphodiesterase activities [42].
  • Opioid agonists affect the activity of adenylate cyclase and ion channels in some tissues, but neither has been shown to mediate opioid analgesia [43].
  • In addition, the possible transducing mechanisms coupling IL-2 receptor stimulation and the electroencephalogram (EEG) spectrum power responses elicited from the locus coeruleus seem to involve stimulation of specific receptors coupled to adenylate cyclase through a Gi protein [44].


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  15. Differences in platelet enzyme activity between alcoholics and nonalcoholics. Tabakoff, B., Hoffman, P.L., Lee, J.M., Saito, T., Willard, B., De Leon-Jones, F. N. Engl. J. Med. (1988) [Pubmed]
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  18. Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis. Hackett, M., Guo, L., Shabanowitz, J., Hunt, D.F., Hewlett, E.L. Science (1994) [Pubmed]
  19. Prostacyclin production and mediation of adenylate cyclase activity in the pulmonary artery. Alterations after prolonged hypoxia in the rat. Shaul, P.W., Kinane, B., Farrar, M.A., Buja, L.M., Magness, R.R. J. Clin. Invest. (1991) [Pubmed]
  20. ATP receptor regulation of adenylate cyclase and protein kinase C activity in cultured renal LLC-PK1 cells. Anderson, R.J., Breckon, R., Dixon, B.S. J. Clin. Invest. (1991) [Pubmed]
  21. Chemoattractant-elicited increases in myosin phosphorylation in Dictyostelium. Berlot, C.H., Spudich, J.A., Devreotes, P.N. Cell (1985) [Pubmed]
  22. A novel nucleotide implicated in the response of E. coli to energy source downshift. Gallant, J., Shell, L., Bittner, R. Cell (1976) [Pubmed]
  23. The 3' terminus of the large ribosomal subunit ("17S") RNA from hamster mitochondria is ragged and oligoadenylated. Dubin, D.T., Timko, K.D., Baer, R.J. Cell (1981) [Pubmed]
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  25. Molecular cloning and expression of a rat V1a arginine vasopressin receptor. Morel, A., O'Carroll, A.M., Brownstein, M.J., Lolait, S.J. Nature (1992) [Pubmed]
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  28. Odorant-sensitive adenylate cyclase may mediate olfactory reception. Pace, U., Hanski, E., Salomon, Y., Lancet, D. Nature (1985) [Pubmed]
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  30. Human serum lipoproteins activate adipocyte plasma membrane adenylate cyclase. Pairault, J., Levilliers, J., Chapman, M.J. Nature (1977) [Pubmed]
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  32. Forskolin activation of adenylate cyclase in vivo stimulates nerve regeneration. Kilmer, S.L., Carlsen, R.C. Nature (1984) [Pubmed]
  33. Substantia nigra of the rat contains a dopamine sensitive adenylate cyclase. Phillipson, O.T., Horn, A.S. Nature (1976) [Pubmed]
  34. Serotonin-activated adenylate cyclase during early development of Schistosoma mansoni. Kasschau, M.R., Mansour, T.E. Nature (1982) [Pubmed]
  35. Progesterone inhibits membrane-bound adenylate cyclase in Xenopus laevis oocytes. Finidori-Lepicard, J., Schorderet-Slatkine, S., Hanoune, J., Baulieu, E.E. Nature (1981) [Pubmed]
  36. A receptor subtype involved in neuropeptide-Y-induced food intake. Gerald, C., Walker, M.W., Criscione, L., Gustafson, E.L., Batzl-Hartmann, C., Smith, K.E., Vaysse, P., Durkin, M.M., Laz, T.M., Linemeyer, D.L., Schaffhauser, A.O., Whitebread, S., Hofbauer, K.G., Taber, R.I., Branchek, T.A., Weinshank, R.L. Nature (1996) [Pubmed]
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  39. PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors. Mertens, I., Vandingenen, A., Johnson, E.C., Shafer, O.T., Li, W., Trigg, J.S., De Loof, A., Schoofs, L., Taghert, P.H. Neuron (2005) [Pubmed]
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