Chemical Compound Review:
Genpharm 4-amino-3-(4- chlorophenyl)butanoic acid
Synonyms:
Lioresal, baclofen, Atrofen, Baclophen, Baclospas, ...
van Hilten,
van de Beek,
Hoff,
Voormolen,
Delhaas,
Kang,
Jiang,
Goldman,
Nedergaard,
White,
McIllhinney,
Wise,
Ciruela,
Chan,
Emson,
Billinton,
Marshall,
Lehmann,
Antonsson,
Bremner-Danielsen,
Flärdh,
Hansson-Brändén,
Kärrberg,
Wiesenfeld-Hallin,
Aldskogius,
Grant,
Hao,
Hökfelt,
Xu,
- Intrathecal baclofen for severe spinal spasticity. Penn, R.D., Savoy, S.M., Corcos, D., Latash, M., Gottlieb, G., Parke, B., Kroin, J.S. N. Engl. J. Med. (1989)
- Baclofen for intractable hiccups. Burke, A.M., White, A.B., Brill, N. N. Engl. J. Med. (1988)
- Intrathecal baclofen for the treatment of dystonia in patients with reflex sympathetic dystrophy. van Hilten, B.J., van de Beek, W.J., Hoff, J.I., Voormolen, J.H., Delhaas, E.M. N. Engl. J. Med. (2000)
- Dual actions of substance P on nociception: possible role of endogenous opioids. Frederickson, R.C., Burgis, V., Harrell, C.E., Edwards, J.D. Science (1978)
- Intrathecal baclofen for spasticity in cerebral palsy. Albright, A.L., Cervi, A., Singletary, J. JAMA (1991)
- Hallucinations after withdrawal of baclofen. Lees, A.J., Clarke, C.R., Harrison, M.J. Lancet (1977)
- A controlled clinical trial of baclofen as protective therapy in early Huntington's disease. Shoulson, I., Odoroff, C., Oakes, D., Behr, J., Goldblatt, D., Caine, E., Kennedy, J., Miller, C., Bamford, K., Rubin, A. Ann. Neurol. (1989)
- Effect of baclofen on sleep-related periodic leg movements. Guilleminault, C., Flagg, W. Ann. Neurol. (1984)
- Baclofen therapy may be associated with chorea in Alzheimer's disease. Crystal, H.A. Ann. Neurol. (1990)
- Baclofen use in the treatment of alcohol delirium tremens. Leggio, L., Abenavoli, L., Caputo, F., Gasbarrini, G., Addolorato, G. Arch. Intern. Med. (2005)
- Novel GABA responses from rod-driven retinal horizontal cells. Qian, H., Dowling, J.E. Nature (1993)
- Direct hyperpolarizing action of baclofen on hippocampal pyramidal cells. Newberry, N.R., Nicoll, R.A. Nature (1984)
- Pre- and postsynaptic GABAB receptors in the hippocampus have different pharmacological properties. Dutar, P., Nicoll, R.A. Neuron (1988)
- Voltage- and ligand-activated inwardly rectifying currents in dorsal raphe neurons in vitro. Williams, J.T., Colmers, W.F., Pan, Z.Z. J. Neurosci. (1988)
- A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus. Averbuch-Heller, L., Tusa, R.J., Fuhry, L., Rottach, K.G., Ganser, G.L., Heide, W., Büttner, U., Leigh, R.J. Ann. Neurol. (1997)
- Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus. McCormick, D.A. J. Neurosci. (1992)
- Light induces chromatin modification in cells of the mammalian circadian clock. Crosio, C., Cermakian, N., Allis, C.D., Sassone-Corsi, P. Nat. Neurosci. (2000)
- Kinetics of GABAB receptor-mediated inhibition of calcium currents and excitatory synaptic transmission in hippocampal neurons in vitro. Pfrieger, F.W., Gottmann, K., Lux, H.D. Neuron (1994)
- Enhancement of synaptic efficacy by presynaptic GABA(B) receptors. Brenowitz, S., David, J., Trussell, L. Neuron (1998)
- GABAB receptor inhibition of P-type Ca2+ channels in central neurons. Mintz, I.M., Bean, B.P. Neuron (1993)
- Activation of the GABA(B) receptor inhibits transient lower esophageal sphincter relaxations in dogs. Lehmann, A., Antonsson, M., Bremner-Danielsen, M., Flärdh, M., Hansson-Brändén, L., Kärrberg, L. Gastroenterology (1999)
- Central inhibitory dysfunctions: mechanisms and clinical implications. Wiesenfeld-Hallin, Z., Aldskogius, H., Grant, G., Hao, J.X., Hökfelt, T., Xu, X.J. The Behavioral and brain sciences. (1997)
- Astrocyte-mediated potentiation of inhibitory synaptic transmission. Kang, J., Jiang, L., Goldman, S.A., Nedergaard, M. Nat. Neurosci. (1998)
- Nerve growth cone guidance mediated by G protein-coupled receptors. Xiang, Y., Li, Y., Zhang, Z., Cui, K., Wang, S., Yuan, X.B., Wu, C.P., Poo, M.M., Duan, S. Nat. Neurosci. (2002)
- Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus. Scanziani, M., Capogna, M., Gähwiler, B.H., Thompson, S.M. Neuron (1992)
- GABA in the nucleus accumbens shell participates in the central regulation of feeding behavior. Stratford, T.R., Kelley, A.E. J. Neurosci. (1997)
- Neurotransmitter activation of inwardly rectifying potassium current in dissociated hippocampal CA3 neurons: interactions among multiple receptors. Sodickson, D.L., Bean, B.P. J. Neurosci. (1998)
- The weaver mutation reverses the function of dopamine and GABA in mouse dopaminergic neurons. Guatteo, E., Fusco, F.R., Giacomini, P., Bernardi, G., Mercuri, N.B. J. Neurosci. (2000)
- The blocking action of baclofen on excitatory transmission in the rat hippocampal slice. Olpe, H.R., Baudry, M., Fagni, L., Lynch, G. J. Neurosci. (1982)
- The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. White, J.H., McIllhinney, R.A., Wise, A., Ciruela, F., Chan, W.Y., Emson, P.C., Billinton, A., Marshall, F.H. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. Martin, S.C., Russek, S.J., Farb, D.H. Mol. Cell. Neurosci. (1999)
- Ts65Dn, a Mouse Model of Down Syndrome, Exhibits Increased GABAB-Induced Potassium Current. Best, T.K., Siarey, R.J., Galdzicki, Z. J. Neurophysiol. (2007)
- Differential effect of baclofen on hypothalamic GnRH and pituitary LH beta gene expression in steroid-treated rats. Cho, B.N., Kim, K. Mol. Cells (1997)
- Molecular and cellular diversity of neuronal G-protein-gated potassium channels. Koyrakh, L., Luján, R., Colón, J., Karschin, C., Kurachi, Y., Karschin, A., Wickman, K. J. Neurosci. (2005)
- Dopamine depletion reorganizes projections from the nucleus accumbens and ventral pallidum that mediate opioid-induced motor activity. Churchill, L., Klitenick, M.A., Kalivas, P.W. J. Neurosci. (1998)
- G protein-coupled receptors mediate a fast excitatory postsynaptic current in CA3 pyramidal neurons in hippocampal slices. Miller, L.D., Petrozzino, J.J., Connor, J.A. J. Neurosci. (1995)