Disease relevance of meclofenamate

• INTERPRETATION: Our findings establish central nervous system dysfunction in the region of the hypothalamus as the primum movens in the pathophysiology of cluster headache [1].
• Idiopathic interstitial pneumonias: Primum movens: epithelial, endothelial or whatever [2].
• Meclofenamate (Meclomen) therapy of psoriasis [3].
• Erythema multiforme induced by meclofenamate sodium (Meclomen) [4].
• The pathogenesis of idiopathic interstitial pneumonias (IIPs), particularly of idiopathic pulmonary fibrosis (IPF), is still unknown and the precise nature of the primum movens is strongly debated [2].

High impact information on meclofenamate

• Female reproductive activity depends upon cyclic morphofunctional changes of the ovarian tissue during the female's fertile period, but the primum movens of an active gonadal rearrangement can be found from early phases of embryo development [5].
• CONCLUSIONS: We propose that endotoxin contamination is the primum movens of a chain of events that involves intra-islet cytokine production and release and islet cell apoptosis, and endotoxin contamination can ultimately lead to primary nonfunction in vivo [6].
• Recent studies using positron emission tomography suggest that a central nervous system dysfunction in the region of the hypothalamus is the primum movens in the pathophysiology of cluster headache [7].
• It was shown that the effort stops as a consequence of exhaustion of postural muscles (rectus abdominis and rectus femoris), and not of the primum movens [8].
• The ankle muscles were activated before the pelvis, the back and the scapular girdle, with the upper limb muscles activated only after the onset of the primum movens of push action (serratus anterior): the activation process followed a distal to proximal progression order [9].

Chemical compound and disease context of meclofenamate

• N-(2,6-Dichloro-m-tolyl) anthranilic acid, sodium salt (meclofenamate sodium, Meclomen) was compared to placebo in two controlled multicenter trials of similar design, one in 180 patients with osteoarthritis of the hip and the other in 237 patients with osteoarthritis of the knee [10].

Biological context of meclofenamate

• Chromosome aberrations and clastogenic activity were not demonstrated after oral administration of Meclomen to male rats [11].
• Plantar-opening wedge osteotomy of the three cuneiform bones, preceded by selective plantar release, corrects forefoot pronation which is the primum movens of the deformity, and corrects the cavus at its apex [12].
• In right ventricle myocardial ischemia and infarction the primum movens of altered right ventricular function is not an increase in afterload, but the ischemic involvement of the right ventricle, more often in the setting of an inferior acute myocardial infarction [13].
• CONCLUSIONS: Infection with H. pylori, especially that expressing CagA-positivity, is primum movens in developing GC and MALT-lymphoma and the upregulation of growth factors, particularly of gastrin, and COX-2 and dysregulation of the Bax/Bcl-2 system seem to contribute to gastric cancerogenesis [14].

Anatomical context of meclofenamate

• The primum movens could be a disorder of the pituitary-adrenal axis secondary to a dysfunction of neurotransmitters with stimulation of ACTH-secreting cells of the adenohypophysis by the certicotropin-releasing factor (CRF) [15].
• The "primum movens" is the activation of the complement pathway mediated by the binding of natural xenogenic antibodies to the endothelium of the graft, followed by the lysis of the endothelial cells with subsequent oedema, thrombosis and necrosis of the transplanted organ [16].
• In Alzheimer disease (AD) the "primum movens" is amyloid (AM) production within the cerebral cortex [17].
• Factors inducing the thickening of arterial intima in childhood considered as "primum movens" of atherogenesis are mentioned [18].
• Massive local adrenaline release is regarded as the primum movens mechanism triggering the liberation of other beta-receptor activators resulting in sterile edema and exudate [19].

Associations of meclofenamate with other chemical compounds

• The analgesic effectiveness of meclofenamate sodium (Meclomen) at two dose levels, 200 mg and 100 mg, was compared with the effectiveness of a placebo and aspirin, 600 mg, in a double-blind study of 174 adult outpatients who had undergone removal of impacted third molars [20].
• Meclofenamic acid sodium (Meclomen) was found to inhibit both the cyclooxygenase and the lipoxygenase pathways of arachidonic acid metabolism [21].

Gene context of meclofenamate

• Clinical manifestations and pathophysiological mechanisms of diabetic angiopathy can be traced back to the development of endothelial cell dysfunction with alterations in the eNOS/NO system production or availability as the primum movens in its natural history [22].
• However, meclomen did show some enhancement of antiproliferative activity of human IFN alpha against human adenocarcinoma lung cells [23].
• Sodium meclofenamate ('Meclomen') in the treatment of rheumatoid arthritis: a double-blind comparison with aspirin and placebo [24].

Analytical, diagnostic and therapeutic context of meclofenamate

• This 6-month, double-blind, controlled clinical trial determined the efficacy of the non-steroidal anti-inflammatory drug, meclofenamate sodium (Meclomen), as an adjunct to scaling and root planing in the treatment of rapidly progressive periodontitis (RPP) [25].

References