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Chemical Compound Review

AGN-PC-00AIJ3     icosa-5,8,11,14-tetraenoic acid

Synonyms: AG-B-56765, AG-F-70356, AG-H-11197, KBioGR_000259, KBioGR_001370, ...
 
 
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Disease relevance of arachidonic acid

 

Psychiatry related information on arachidonic acid

 

High impact information on arachidonic acid

 

Chemical compound and disease context of arachidonic acid

 

Biological context of arachidonic acid

 

Anatomical context of arachidonic acid

 

Associations of arachidonic acid with other chemical compounds

 

Gene context of arachidonic acid

  • We show that cPLA2 selectively cleaves arachidonic acid from natural membrane vesicles and demonstrate that cPLA2 translocates to membrane vesicles in response to physiologically relevant changes in free calcium [34].
  • Mice lacking COX-2 have normal inflammatory responses to treatments with tetradecanoyl phorbol acetate or with arachidonic acid [35].
  • Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid [36].
  • Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability: involvement of the CD14 antigen [37].
  • These eicosanoids, formed by cyclooxygenase-dependent metabolism of arachidonic acid, are important physiologic mediators of renal glomerular hemodynamics and tubular sodium and water reabsorption [38].
 

Analytical, diagnostic and therapeutic context of arachidonic acid

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