Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

TCAB bis(3,4-dichlorophenyl)diazene

Synonyms: CCRIS 1273, LS-824, AG-D-81155, BRN 4871675, AC1L1B40, ...

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Disease relevance of CCRIS 1273

Toxicity of 3,3',4,4'-tetrachloroazobenzene in rats and mice [1].
A delayed wasting syndrome similar to that induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was observed in male Sprague-Dawley rats exposed to 3,3', 4,4'-tetrachloroazoxybenzene (TCAOB) and 3,3',4,4'-tetrachloroazobenzene (TCAB) [2].

High impact information on CCRIS 1273

The genetic toxicity of 3,3',4,4'-tetrachloroazobenzene and 3,3',4, 4'-tetrachloroazoxybenzene: discordance between acute mouse bone marrow and subchronic mouse peripheral blood micronucleus test results [3].
The clearance profile and tissue distribution of 2 occupational toxicants, 3,3',4,4'-tetrachloroazobenzene (TCAB) and 3,3',4,4'-tetrachloroazoxybenzene (TCAOB), were examined in male Sprague-Dawley rats [4].
An increased alkaline elution of DNA was also observed following IQ addition to cultures of hepatocytes from 3,3',4,4'-tetrachloroazobenzene-induced rat liver, and the DNA damage was again dose related [5].
The effects of 3,3',4,4'-tetrachloroazobenzene (TCAB) and 3,3',4,4'-tetrachloroazoxybenzene (TCAOB) on lymphoid organs in male Sprague-Dawley rats were investigated in various acute exposure studies [6].
Embryotoxicity of 3,3',4,4'-tetrachloroazobenzene and 3,3',4,4'-tetrachloroazoxybenzene in the chick embryo [7].

Chemical compound and disease context of CCRIS 1273

The toxicity of 3,3',4,4'-tetrachloroazobenzene (TCAB) and 3,3',4,4'-tetrachloroazoxybenzene (TCAOB) to chick embryos was examined [7].

Anatomical context of CCRIS 1273

Metabolism studies of 3,3',4,4'-tetrachloroazobenzene. I. In vitro metabolic pathways with rat liver microsomes [8].

Associations of CCRIS 1273 with other chemical compounds

The metabolism of 3,3',4,4'-tetrachloroazobenzene (TCAB), an important environmental and occupational toxicant, by rat liver microsomes has been examined in a NADPH-generating system [8].

Gene context of CCRIS 1273

Induction of hepatic microsomal cytochrome P-448 by 3,3',4,4'-tetrachloroazobenzene and the corresponding azoxy and hydrazo analogs [9].

References

Toxicity of 3,3',4,4'-tetrachloroazobenzene in rats and mice. van Birgelen, A.P., Hébert, C.D., Wenk, M.L., Grimes, L.K., Chapin, R.E., Mahler, J., Travlos, G.S., Bucher, J.R. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
Delayed wasting syndrome and alterations of liver gluconeogenic enzymes in rats exposed to the TCDD congener 3,3', 4,4'-tetrachloroazoxybenzene. Hsia, M.T., Kreamer, B.L. Toxicol. Lett. (1985) [Pubmed]
The genetic toxicity of 3,3',4,4'-tetrachloroazobenzene and 3,3',4, 4'-tetrachloroazoxybenzene: discordance between acute mouse bone marrow and subchronic mouse peripheral blood micronucleus test results. Witt, K.L., Zeiger, E., Tice, R.R., van Birgelen, A.P. Mutat. Res. (2000) [Pubmed]
Excretion and distribution of two occupational toxicants, tetrachloroazobenzene and tetrachloroazoxybenzene in the rat. Burant, C.F., Hsia, M.T. Toxicology (1984) [Pubmed]
DNA damage of mammalian cells by the beef extract mutagen 2-amino-3-methylimidazo[4,5-f]quinoline. Caderni, G., Kreamer, B.L., Dolara, P. Food Chem. Toxicol. (1983) [Pubmed]
Thymic atrophy induced by acute exposure of 3,3',4,4'-tetrachloroazobenzene and 3,3',4,4'-tetrachloroazoxybenzene in rats. Hsia, M.T., Burant, C.F., Kreamer, B.L., Schrankel, K.R. Toxicology (1982) [Pubmed]
Embryotoxicity of 3,3',4,4'-tetrachloroazobenzene and 3,3',4,4'-tetrachloroazoxybenzene in the chick embryo. Schrankel, K.R., Kreamer, B.L., Hsia, M.T. Arch. Environ. Contam. Toxicol. (1982) [Pubmed]
Metabolism studies of 3,3',4,4'-tetrachloroazobenzene. I. In vitro metabolic pathways with rat liver microsomes. Hsia, M.T., Kreamer, B.L. Chem. Biol. Interact. (1981) [Pubmed]
Induction of hepatic microsomal cytochrome P-448 by 3,3',4,4'-tetrachloroazobenzene and the corresponding azoxy and hydrazo analogs. Hsia, M.T., Kreamer, B.L. Res. Commun. Chem. Pathol. Pharmacol. (1979) [Pubmed]

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