Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Helmatac methylN-(6-butyl-1H- benzoimidazol-2...

Synonyms: Verminum, Helatac, Parbendazol, PBDZ, Parbendazole, ...

Havercroft, J.C. et al., Prozesky, L. et al., Quinlan, R.A. et al., Upcroft, J. et al.

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High impact information on Parbendazole

Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy [1].
Immunofluorescence studies using antitubulin antibody showed that parbendazole effectively depolymerizes cytoplasmic microtubules in animal cells leaving only one or two microtubules associated with one centriole [1].
Albendazole-resistant Giardia were cross-resistant to parbendazole [2].
Out of a total of 68 lambs, born from ewes treated at various stages of gestation with parbendazole at 180 mg/kg, 5 showed the paralysis syndrome, 5 showed skeletal deformities, 2 were ataxic, while 1 foetus was aborted [3].
A correlation between in vivo and in vitro effects of the microtubule inhibitors colchicine, parbendazole and nocodazole on myxamoebae of Physarum polycephalum [4].

References

Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. Havercroft, J.C., Quinlan, R.A., Gull, K. J. Cell. Sci. (1981) [Pubmed]
Albendazole resistance in Giardia is correlated with cytoskeletal changes but not with a mutation at amino acid 200 in beta-tubulin. Upcroft, J., Mitchell, R., Chen, N., Upcroft, P. Microb. Drug Resist. (1996) [Pubmed]
Paralysis in lambs caused by overdosing with parbendazole. Prozesky, L., Joubert, J.P., Ekron, M.D. Onderstepoort J. Vet. Res. (1981) [Pubmed]
A correlation between in vivo and in vitro effects of the microtubule inhibitors colchicine, parbendazole and nocodazole on myxamoebae of Physarum polycephalum. Quinlan, R.A., Roobol, A., Pogson, C.I., Gull, K. J. Gen. Microbiol. (1981) [Pubmed]

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