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Chemical Compound Review

AC1MBZLL     N-[4-[ (carbamothioylhydrazinylidene) methyl...

Synonyms: AG-C-14988, AG-D-15782, CTK6A0755, KB-188929, MCULE-4893643717, ...
 
 
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Disease relevance of Thioacetazon

 

High impact information on Thioacetazon

  • In contrast, MAb 42/6 had minimal effects on cytotoxicity of the ribonucleotide reductase inhibitor, isoquinaldehyde thiosemicarbazone, to either HL60 or KB cells [5].
  • Among HIV-positive patients who received treatment for active tuberculosis, thiacetazone has been associated with cutaneous hypersensitivity and recurrent tuberculosis [1].
  • As an alternative approach to using P-gp inhibitors, we characterize a thiosemicarbazone derivative (NSC73306) identified in a generic screen as a compound that exploits, rather than suppresses, P-gp function to induce cytotoxicity [6].
  • While the ED2 cells showed resistance to 2,3-dihydro-1H-pyrazole-[2,3a]-imidazole/Desferal (6-fold), the ED1 and ED2 cell lines showed less resistance to hydroxyurea, 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone, and the dialdehyde of inosine [7].
  • Studies were carried out to determine the effects of preincubation of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ) with hepatic microsomes on the ability of MAIQ to inhibit CDP reductase activity in vitro [8].
 

Chemical compound and disease context of Thioacetazon

 

Biological context of Thioacetazon

 

Anatomical context of Thioacetazon

 

Associations of Thioacetazon with other chemical compounds

 

Gene context of Thioacetazon

 

Analytical, diagnostic and therapeutic context of Thioacetazon

References

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  2. Thiacetazone-induced hypersensitivity. Kole, H.M. Lancet (1991) [Pubmed]
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  18. Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice. Bermudez, L.E., Reynolds, R., Kolonoski, P., Aralar, P., Inderlied, C.B., Young, L.S. Antimicrob. Agents Chemother. (2003) [Pubmed]
  19. Novel tetranuclear orthometalated complexes of Pd(II) and Pt(II) derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cell lines. Interaction of these complexes with DNA. Quiroga, A.G., Pérez, J.M., López-Solera, I., Masaguer, J.R., Luque, A., Román, P., Edwards, A., Alonso, C., Navarro-Ranninger, C. J. Med. Chem. (1998) [Pubmed]
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  26. Synthesis, characterisation, X-ray structure and biological activity of three new 5-formyluracil thiosemicarbazone complexes. Ferrari, M.B., Bisceglie, F., Pelosi, G., Tarasconi, P., Albertin, R., Bonati, A., Lunghi, P., Pinelli, S. J. Inorg. Biochem. (2001) [Pubmed]
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  28. Flow cytometric determination of estrogen receptors in intact cells. Oxenhandler, R.W., McCune, R., Subtelney, A., Truelove, C., Tyrer, H.W. Cancer Res. (1984) [Pubmed]
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