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Chemical Compound Review

SureCN35371     8-(6-aminopurin-9-yl)-3- hydroxy-3-oxo-2,4...

Synonyms: AGN-PC-00JUGS, NSC-94017, Probes1_000341, Probes2_000489, NSC-127975, ...
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Disease relevance of Cyclic AMP


Psychiatry related information on Cyclic AMP


High impact information on Cyclic AMP


Chemical compound and disease context of Cyclic AMP


Biological context of Cyclic AMP


Anatomical context of Cyclic AMP


Associations of Cyclic AMP with other chemical compounds

  • These results suggest that the synthesis of both cyclic GMP and cyclic AMP is mediated by the same enzyme, adenylate cyclase, Interestingly, a reciprocal effect of glucose starvation was observed on the accumulation of both cyclic nucleotides [28].
  • It has been proposed that adenosine is toxic to lymphoid cells by virtue of its ability to increase the intracellular concentrations of cyclic AMP [29].
  • Prostaglandin E1 increased lymphocyte cyclic AMP five to 10 times whereas prostagladin F2alpha did not affect cellular levels of this nucleotide [27].
  • Dual control for transcription of the galactose operon by cyclic AMP and its receptor protein at two interspersed promoters [30].
  • Milrinone, a phosphodiesterase inhibitor, enhances cardiac contractility by increasing intracellular levels of cyclic AMP, but the long-term effect of this type of positive inotropic agent on the survival of patients with chronic heart failure has not been determined [31].

Gene context of Cyclic AMP


Analytical, diagnostic and therapeutic context of Cyclic AMP

  • In this study, we used two-dimensional gel electrophoresis to analyze the responses of cultured S49 mouse lymphoma cells to incubation with analogs or inducers of cyclic AMP (cAMP) [2].
  • To test this hypothesis we studied the ability of NA alone and in combination with alpha-and beta-adrenergic antagonists to increase cyclic AMP levels and to mimic the effects of nerves by maintaining high rates of protein synthesis and high mitotic indices (MI) in denervated blastemata in organ culture [36].
  • Here we report the localization of myosin 'rods', analogous to the thick filaments of muscle, by ameliorated immunofluorescence and demonstrate the dynamic translocation of these rods in response to exogenously added cyclic AMP, which is a chemoattractant for Dictyostelium amoebae [37].
  • We report here that in a bursting molluscan neurone, intracellular iontophoresis of cyclic AMP under voltage clamp elicits an inward current of maximal amplitude in the pacemaker voltage region [38].
  • We have used gene targeting to selectively eliminate the transcription factor CREM (cyclic AMP- responsive element modulator), which is thought to be important for mammalian spermatogenesis [39].


  1. How cyclic AMP and its receptor protein act in Escherichia coli. Adhya, S., Garges, S. Cell (1982) [Pubmed]
  2. Two-dimensional gel analysis of cyclic AMP effects in cultured S49 mouse lymphoma cells: protein modifications, inductions and repressions. Steinberg, R.A., Coffino, P. Cell (1979) [Pubmed]
  3. Localization of pheochromocytoma by measurement of plasma cyclic AMP. Miura, Y., Nezu, M., Kimura, S., Yoshinaga, K., Endoh, M. N. Engl. J. Med. (1984) [Pubmed]
  4. Defect of receptor-cyclase coupling protein in psudohypoparathyroidism. Farfel, Z., Brickman, A.S., Kaslow, H.R., Brothers, V.M., Bourne, H.R. N. Engl. J. Med. (1980) [Pubmed]
  5. Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups. Stewart, A.F., Horst, R., Deftos, L.J., Cadman, E.C., Lang, R., Broadus, A.E. N. Engl. J. Med. (1980) [Pubmed]
  6. Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation. Mann, J.J., Brown, R.P., Halper, J.P., Sweeney, J.A., Kocsis, J.H., Stokes, P.E., Bilezikian, J.P. N. Engl. J. Med. (1985) [Pubmed]
  7. Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha. Maillet, M., Robert, S.J., Cacquevel, M., Gastineau, M., Vivien, D., Bertoglio, J., Zugaza, J.L., Fischmeister, R., Lezoualc'h, F. Nat. Cell Biol. (2003) [Pubmed]
  8. Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases. Wei, F., Qiu, C.S., Kim, S.J., Muglia, L., Maas, J.W., Pineda, V.V., Xu, H.M., Chen, Z.F., Storm, D.R., Muglia, L.J., Zhuo, M. Neuron (2002) [Pubmed]
  9. Abnormal levels of 3':5'-cyclic AMP in isoproterenol-stimulated fibroblasts from patients with cystic fibrosis. Buchwald, M. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  10. Cyclic AMP signal transduction in posttraumatic stress disorder. Lerer, B., Ebstein, R.P., Shestatsky, M., Shemesh, Z., Greenberg, D. The American journal of psychiatry. (1987) [Pubmed]
  11. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Hanson, R.W., Reshef, L. Annu. Rev. Biochem. (1997) [Pubmed]
  12. Transcriptional regulation by cyclic AMP. Montminy, M. Annu. Rev. Biochem. (1997) [Pubmed]
  13. The structure and regulation of protein phosphatases. Cohen, P. Annu. Rev. Biochem. (1989) [Pubmed]
  14. Phosphorylation-regulated Cl- channel in CHO cells stably expressing the cystic fibrosis gene. Tabcharani, J.A., Chang, X.B., Riordan, J.R., Hanrahan, J.W. Nature (1991) [Pubmed]
  15. Spermine inhibits induction of ornithine decarboxylase by cyclic AMP but not by dexamethasone in rat hepatoma cells. Theoharides, T.C., Cannelakis, Z.N. Nature (1975) [Pubmed]
  16. Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease. Torres, V.E., Wang, X., Qian, Q., Somlo, S., Harris, P.C., Gattone, V.H. Nat. Med. (2004) [Pubmed]
  17. Selective reduction of forskolin-stimulated cyclic AMP accumulation by inhibitors of protein synthesis. Brooker, G., Pedone, C., Barovsky, K. Science (1983) [Pubmed]
  18. Growth arrest and morphological change of human breast cancer cells by dibutyryl cyclic AMP and L-arginine. Cho-Chung, Y.S., Clair, T., Bodwin, J.S., Berghoffer, B. Science (1981) [Pubmed]
  19. A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1. Boshart, M., Weih, F., Schmidt, A., Fournier, R.E., Schütz, G. Cell (1990) [Pubmed]
  20. Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit. Xu, X., Toselli, P.A., Russell, L.D., Seldin, D.C. Nat. Genet. (1999) [Pubmed]
  21. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. Weinstein, L.S., Shenker, A., Gejman, P.V., Merino, M.J., Friedman, E., Spiegel, A.M. N. Engl. J. Med. (1991) [Pubmed]
  22. Schwann cell growth factors. Raff, M.C., Abney, E., Brockes, J.P., Hornby-Smith, A. Cell (1978) [Pubmed]
  23. Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation. Kato, J.Y., Matsuoka, M., Polyak, K., Massagué, J., Sherr, C.J. Cell (1994) [Pubmed]
  24. Stimulus-response coupling in neurohypophysial peptide target cells. Jard, S., Bockaert, J. Physiol. Rev. (1975) [Pubmed]
  25. Antibodies that promote thyroid growth. A distinct population of thyroid-stimulating autoantibodies. Valente, W.A., Vitti, P., Rotella, C.M., Vaughan, M.M., Aloj, S.M., Grollman, E.F., Ambesi-Impiombato, F.S., Kohn, L.D. N. Engl. J. Med. (1983) [Pubmed]
  26. Letter: Lower lymphocyte cyclic-AMP levels after aspirin. Snider, D.E., Parker, C.W. N. Engl. J. Med. (1975) [Pubmed]
  27. Adherence of human peripheral blood lymphycytes to measles-infected cells. Enhancement by prostaglandin E1. Zurier, R.B., Dore-Duffy, P., Viola, M.V. N. Engl. J. Med. (1977) [Pubmed]
  28. A possible involvement of cya gene in the synthesis of cyclic guanosine 3':5'-monophosphate in E. coli. Shibuya, M., Takebe, Y., Kaziro, Y. Cell (1977) [Pubmed]
  29. Characterization of a cell culture model for the study of adenosine deaminase- and purine nucleoside phosphorylase-deficient immunologic disease. Ullman, B., Cohen, A., Martin, D.W. Cell (1976) [Pubmed]
  30. Dual control for transcription of the galactose operon by cyclic AMP and its receptor protein at two interspersed promoters. Musso, R.E., Di Lauro, R., Adhya, S., de Crombrugghe, B. Cell (1977) [Pubmed]
  31. Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. Packer, M., Carver, J.R., Rodeheffer, R.J., Ivanhoe, R.J., DiBianco, R., Zeldis, S.M., Hendrix, G.H., Bommer, W.J., Elkayam, U., Kukin, M.L. N. Engl. J. Med. (1991) [Pubmed]
  32. The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S., Wigler, M. Cell (1987) [Pubmed]
  33. DNA binding activities of three murine Jun proteins: stimulation by Fos. Nakabeppu, Y., Ryder, K., Nathans, D. Cell (1988) [Pubmed]
  34. A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia. Horvath, A., Boikos, S., Giatzakis, C., Robinson-White, A., Groussin, L., Griffin, K.J., Stein, E., Levine, E., Delimpasi, G., Hsiao, H.P., Keil, M., Heyerdahl, S., Matyakhina, L., Libè, R., Fratticci, A., Kirschner, L.S., Cramer, K., Gaillard, R.C., Bertagna, X., Carney, J.A., Bertherat, J., Bossis, I., Stratakis, C.A. Nat. Genet. (2006) [Pubmed]
  35. Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR1. Cherry, J.R., Johnson, T.R., Dollard, C., Shuster, J.R., Denis, C.L. Cell (1989) [Pubmed]
  36. Noradrenaline and cyclic AMP--independent growth stimulation in newt limb blastemata. Rathbone, M.P., Petri, J., Choo, A.F., Logan, D.M., Carlone, R.L., Foret, J.E. Nature (1980) [Pubmed]
  37. Reversible cyclic AMP-dependent change in distribution of myosin thick filaments in Dictyostelium. Yumura, S., Fukui, Y. Nature (1985) [Pubmed]
  38. Patch- and voltage-clamp analysis of cyclic AMP-stimulated inward current underlying neurone bursting. Green, D.J., Gillette, R. Nature (1983) [Pubmed]
  39. Severe impairment of spermatogenesis in mice lacking the CREM gene. Blendy, J.A., Kaestner, K.H., Weinbauer, G.F., Nieschlag, E., Schütz, G. Nature (1996) [Pubmed]
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