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Chemical Compound Review

3-DEAZAURIDINE     1-[3,4-dihydroxy-5- (hydroxymethyl)oxolan-2...

Synonyms: DeazaUrd, bmse000731, NSC-126849, AC1L5MSF, ICN 1007, ...
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Disease relevance of 3-DEAZAURIDINE


High impact information on 3-DEAZAURIDINE


Chemical compound and disease context of 3-DEAZAURIDINE


Biological context of 3-DEAZAURIDINE


Associations of 3-DEAZAURIDINE with other chemical compounds


Gene context of 3-DEAZAURIDINE


Analytical, diagnostic and therapeutic context of 3-DEAZAURIDINE


  1. Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline in neoplastic and normal cells. Lauzon, G.J., Paterson, A.R., Belch, A.W. Cancer Res. (1978) [Pubmed]
  2. The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine. Jackson, R.C. J. Biol. Chem. (1978) [Pubmed]
  3. Effects of 2-deoxy-D-glucose and 3 deazauridine individually and in combination on the replication of Japanese B encephalitis virus. Woodman, D.R., Williams, J.C. Antimicrob. Agents Chemother. (1977) [Pubmed]
  4. Toxicity of combinations of arabinosylcytosine and 3-deazauridine toward neoplastic cells in culture. Mills-Yamamoto, C., Lauzon, G.J., Paterson, A.R. Biochem. Pharmacol. (1978) [Pubmed]
  5. 3-Deazauridine triggers dose-dependent apoptosis in myeloid leukemia cells and enhances retinoic acid-induced granulocytic differentiation of HL-60 cells. Savickiene, J., Gineitis, A. Int. J. Biochem. Cell Biol. (2003) [Pubmed]
  6. Dual effects of pyrazofurin and 3-deazauridine upon pyrimidine and purine biosynthesis in mouse L1210 leukemia. Sant, M.E., Lyons, S.D., Kemp, A.J., McClure, L.K., Szabados, E., Christopherson, R.I. Cancer Res. (1989) [Pubmed]
  7. In vivo cellular kinetic and pharmacological studies of 1-beta-D-arabinofuranosylcytosine and 3-deazauridine chemotherapy for relapsing acute leukemia. Barlogie, B., Plunkett, W., Raber, M., Latreille, J., Keating, M., McCredie, K. Cancer Res. (1981) [Pubmed]
  8. Pharmacokinetics and disposition of 3-deazauridine in humans. Benvenuto, J.A., Hall, S.W., Farquhar, D., Stewart, D.J., Benjamin, R.S., Loo, T.L. Cancer Res. (1979) [Pubmed]
  9. Penetration of 3-deazauridine into human brain, intracerebral tumor, and cerebrospinal fluid. Stewart, D.J., Benvenuto, J.A., Leavens, M., Hall, S.W., Benjamin, R.S., Plunkett, W., McCredie, K.B., Burgess, M.A., Loo, T.L. Cancer Res. (1979) [Pubmed]
  10. 2',3'-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis. Balzarini, J., Cooney, D.A., Dalal, M., Kang, G.J., Cupp, J.E., DeClercq, E., Broder, S., Johns, D.G. Mol. Pharmacol. (1987) [Pubmed]
  11. Modulation of cytosine arabinoside toxicity by 3-deazauridine in a murine leukemia model. Grem, J.L., Plowman, J., Rubinstein, L., Hawkins, M.J., Harrison, S.D. Leuk. Res. (1991) [Pubmed]
  12. Kinetics of deamination of 5-aza-2'-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside. Chabot, G.G., Bouchard, J., Momparler, R.L. Biochem. Pharmacol. (1983) [Pubmed]
  13. Ara-C metabolism: implications for drug resistance and drug interactions. Chabner, B.A., Hande, K.R., Drake, J.C. Bulletin du cancer. (1979) [Pubmed]
  14. The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate. van Berg, A.A., Mooyer, P.A., van Lenthe, H., Stet, E.H., De Abreu, R.A., van Kuilenburg, A.B., van Gennip, A.H. Biochem. Pharmacol. (1995) [Pubmed]
  15. Regulation of pyrimidine biosynthesis in cultured L1210 cells by 3-deazauridine. Karle, J.M., Cysyk, R.L. Biochem. Pharmacol. (1984) [Pubmed]
  16. Chemotherapy of L1210 and L1210/ARA-C leukemia with 5-aza-2'-deoxycytidine and 3-deazauridine. Momparler, R.L., Momparler, L.F. Cancer Chemother. Pharmacol. (1989) [Pubmed]
  17. Enzyme pattern-directed chemotherapy: synergistic interaction of 3-deazauridine with D-galactosamine. Jackson, R.C., Williams, J.C., Weber, G. Cancer treatment reports. (1976) [Pubmed]
  18. Correlation of nucleoside and nucleobase transporter gene expression with antimetabolite drug cytotoxicity. Lu, X., Gong, S., Monks, A., Zaharevitz, D., Moscow, J.A. J. Exp. Ther. Oncol. (2002) [Pubmed]
  19. Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism. Heinemann, V., Schulz, L., Issels, R.D., Plunkett, W. Semin. Oncol. (1995) [Pubmed]
  20. Sample preparation and estimation of plasma concentration of 3-deazauridine by high-performance liquid chromatography. Lin, K.T., Momparler, R.L., Rivard, G.E. Therapeutic drug monitoring. (1983) [Pubmed]
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