Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

CHEMBL164131 N,N-diprop-2-enylnitrous amide

Synonyms: CCRIS 6153, NSC-37648, LS-7130, NSC37648, NSC 37648, ...

Bauman, P.A. et al., Pour, P.M. et al., Grandjean, C.J. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of N-Nitrosodiallylamine

Weekly intragastric administration of 20, 40, and 80 mg/kg body weight diallylnitrosamine to BD IX rats selectively induced nasal and paranasal cavity tumors with incidences of 30%, 85%, and 65% in females and of 0%, 75%, and 80% in males, respectively [1].

High impact information on N-Nitrosodiallylamine

Single and multiple intragastric doses of diallylnitrosamine [(DAN) CAS: 16338-97-9] administered to Syrian golden hamsters induced tumors, primarily of the respiratory tract, in which the nasal cavity epithelium was the preferred site [2].
These data indicate that the allyl group of N-nitrosodiallylamine is readily oxidized by hepatocytes in vitro [3].

Associations of N-Nitrosodiallylamine with other chemical compounds

Isolated rat hepatocytes were incubated with approximately equimolar amounts of N-nitrosodi-n-propylamine (NDPA) and N-nitrosodiallylamine (NDAA) in order to compare their metabolism [3].

References

Selective induction of nasal cavity tumors in rats by diallylnitrosamine. Pour, P.M., Grandjean, C.J., Knepper, S. J. Cancer Res. Clin. Oncol. (1985) [Pubmed]
Carcinogenicity of diallylnitrosamine following intragastric administration to Syrian hamsters. Grandjean, C.J., Althoff, J., Pour, P.M. J. Natl. Cancer Inst. (1985) [Pubmed]
Metabolism of N-nitrosodi-n-propylamine and N-nitrosodiallylamine by isolated rat hepatocytes. Bauman, P.A., Hotchkiss, J.H., Parker, R.S. Cancer Lett. (1985) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use

[search][advanced]