Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Muscarone trimethyl-[(5-methyl-4-oxo- oxolan-2...

Synonyms: Allomuscarone, AC1MIY1P, 4780-69-2, 13552-60-8

Carroll, P.J. et al., Tsukamoto, S. et al.

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High impact information on Allomuscarone

MM2 calculations predicted a preferred gauche arrangement of the side chain for 1 and its analogues; such an arrangement was also observed in the solid state of muscarone picrate [1].
Structure-activity relationships are discussed in comparison with those for muscarone analogues [2].

References

Conformational studies of muscarone analogues: X-ray analysis and molecular mechanics calculations. Carroll, P.J., De Amici, M., De Micheli, C., Toma, L. J. Med. Chem. (1992) [Pubmed]
Synthesis and structure-activity studies of a series of 1-oxa-8-azaspiro[4.5]decanes as M1 muscarinic agonists. Tsukamoto, S., Fujii, M., Yasunaga, T., Matsuda, K., Wanibuchi, F., Hidaka, K., Furuya, T., Tamura, T. Chem. Pharm. Bull. (1995) [Pubmed]

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