Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Corynetoxin N-[(2R,3R,4R,5S,6R)-2- [(2S,3R,4R,5R)-6-[2...

Synonyms: AC1MJ5O4, 82196-90-5

Jago, M.V. et al., Vogel, P. et al., Yeoh, G.C. et al., Finnie, J.W. et al.

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Disease relevance of Corynetoxin

Ultrastructural changes in the cerebellum of nursling rats given corynetoxin, the aetiological agent of annual ryegrass toxicity [1].

High impact information on Corynetoxin

Effect of corynetoxin isolated from parasitized annual ryegrass on albumin and transferrin synthesis and secretion by cultured fetal rat hepatocytes [2].
The lethal dose was about 35 micrograms/kg bodyweight for pure tunicamycin given by subcutaneous injection and 3 to 5 mg/kg for corynetoxin administered orally as slurries of bacterial galls of known corynetoxin content [3].

Chemical compound and disease context of Corynetoxin

Quantitative toxicity studies were carried out in sheep using corynetoxin, tunicamycin and toxic annual ryegrass (Lolium rigidum) [3].

Analytical, diagnostic and therapeutic context of Corynetoxin

The name 'corynetoxin' is tentatively proposed for the series, individual members being designated according to their order of elution from the high performance liquid chromatography column as corynetoxins 1 to 8 [4].

References

Ultrastructural changes in the cerebellum of nursling rats given corynetoxin, the aetiological agent of annual ryegrass toxicity. Finnie, J.W., Mukherjee, T.M. J. Comp. Pathol. (1986) [Pubmed]
Effect of corynetoxin isolated from parasitized annual ryegrass on albumin and transferrin synthesis and secretion by cultured fetal rat hepatocytes. Yeoh, G.C., Vogel, P., Daly, J., Brighton, V.J., Light, A., Petterson, D.S. Exp. Cell Res. (1984) [Pubmed]
Tunicamycin and corynetoxin poisoning in sheep. Jago, M.V., Culvenor, C.C. Aust. Vet. J. (1987) [Pubmed]
Isolation of a group of glycolipid toxins from seedheads of annual ryegrass Lolium rigidum Gaud.) infected by Corynebacterium rathayi. Vogel, P., Petterson, D.S., Berry, P.H., Frahn, J.L., Anderton, N., Cockrum, P.A., Edgar, J.A., Jago, M.V., Lanigan, G.W., Payne, A.L., Culvenor, C.C. The Australian journal of experimental biology and medical science. (1981) [Pubmed]

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