Disease relevance of Arthrex

• Thus, at present, proquazone would seem to be as effective as other NSAIDs used in the management of rheumatoid arthritis and osteoarthritis [1].
• Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states [1].
• Treatment of acute gouty arthritis with proquazone and indomethacin. A comparative, double-blind trial [2].
• We describe using a core harvester, the Osteochondral Autograft Transfer System (OATS; Arthrex, Naples, Fla), to remove a Herbert-Whipple screw placed earlier in a failed attempt to fix an osteochondritis dissecans lesion on the lateral aspect of the medial femoral condyle [3].
• In 13 patients with hydrarthrosis of the knee, samples of synovial fluid and blood were drawn at regular intervals, following a single oral dose of 600 mg proquazone [4].

High impact information on Arthrex

• Evidence from small groups of patients with rheumatoid arthritis treated for a year or more suggests that proquazone may inhibit or arrest progression of bone erosions [1].
• Study aims were to evaluate the biomechanical properties of Mitek GII anchors compared with the Arthrex Bio-Tenodesis Screw for free tendon reconstruction of the anterior talofibular ligament [5].
• The clinical application of this method suggests that the pharmacokinetics of proquazone in adults and children are similar [6].
• For adequate intravenous dosing of the poorly water-soluble proquazone, advantage was taken of the high degree of protein binding of the drug [7].
• The pharmacokinetics of proquazone and of the measured metabolites after intravenous administration and after the 300-mg po dose were first order, whereas deviations from linear kinetics were observed at the 900-mg dose level [7].

Chemical compound and disease context of Arthrex

• A new anti-inflammatory drug, proquazone, and ibuprofen in the treatment of degenerative joint disease of the knee (gonarthrosis). A double-blind comparative study [8].
• The efficacy and tolerance of 900 mg/day proquazone were compared with those of 500 mg/day naproxen in a three-month trial with 40 patients suffering from osteoarthritis of the hip [9].

Biological context of Arthrex

• In addition, a round-threaded titanium (RCI; Smith & Nephew DonJoy, Carlsbad, CA), a round-threaded biodegradable screw (Sysorb; Sulzer Orthopedics, Münsingen, Switzerland), and a conventional titanium interference screw (Arthrex Inc, Naples, FL) were compared [10].
• Percutaneous absorption of griseofulvin and proquazone in the rat and in isolated human skin [11].
• Immunological effects of Biarison in the treatment of rheumatoid arthritis and systemic lupus erythematosus. A preliminary report [12].
• The toxicology profile of the anti-inflammatory drug proquazone in animals [13].
• Possible explanations for this effect are discussed and it is concluded that the administration of proquazone with or after food should be doubly advantageous for the patient as it ought to offer protection from local gastrointestinal irritation and at the same time lead to an enhanced bioavailability [14].

Anatomical context of Arthrex

• Protein binding and erythrocyte partitioning of the antirheumatic proquazone [15].
• The analgesic efficacy of 75, 150, and 300 mg proquazone, a new nonsteroidal antiinflammatory agents, was compared to that of 650 mg aspirin and a placebo in outpatients who had moderate or severe pain following the surgical removal of impacted third molars [16].
• The objective of this study was to evaluate the initial fixation strength of a metal interference screw (9 x 25 mm; Arthrex, Naples, FL) with respect to its position relative to the bone plug in anterior cruciate ligament reconstruction using a bone-patellar tendon-bone graft [17].
• The surgical technique was based on an arthroscopically assisted reconstruction of the coracoclavicular ligaments with a suture anchor (Arthrex, Naples, FL, USA) and a supplemental stabilization of the AC-joint capsule with a suture cerclage (Fibre Wire 2, Arthrex) performed on ten cadaveric shoulder specimens [18].
• The distribution of proquazone and three of its metabolites in serum and synovial fluid [4].

Associations of Arthrex with other chemical compounds

• The objective of this study was to evaluate the fixation strength of a biodegradable interference screw (Arthrex, Naples, FL) compared with press fit fixation and a titanium interference screw in anterior cruciate ligament (ACL) reconstruction using a bone-patellar tendon-bone (BPTB) graft [19].
• Eighteen patients (11 men and 7 women) suffering from primary or secondary gout, were treated with either proquazone or indomethacin for acute attacks in a double-blind study [2].
• The efficacy and tolerance of proquazone, 900 mg, and ibuprofen, 1200 mg, were compared in a randomized, double-blind clinical trial of 6 months' duration, with 44 patients, 21 on proquazone and 23 on ibuprofen [20].
• A comparative, double-blind trial with proquazone and naproxen in the treatment of rheumatoid arthritis [21].
• The oedema disk technique was used to study the effects of orally administered nonsteroidal antiphlogistics (piroxicam, phenylbutazone, proquazone, azapropazone and nifluminic acid) on the inflammation induced with croton oil in the mouse ear [22].

Gene context of Arthrex

• Two cases of stress reaction of the medial supracondylar area of the femur after ACL reconstruction with hamstring tendons using BioTransfix (Arthrex, Naples, FL, USA) devices for fixation within femur are presented [23].
• Cyclic fatigue strength was significantly less for the 10-mm Bionix Arrow, the S.D. Sorb Stapler, and the 12-mm Arthrex Meniscal Dart (P<0.01) compared to all other devices [24].
• Mean axial stiffness was 2425 N/mm, 2358 N/mm and 2258 N/mm, respectively, for the EBI, Arthrex, and Alaron surgical plates [25].
• PURPOSE: The present study was conducted to evaluate 4 different fluid delivery systems: Arthrex AR-6450, Stryker 1.5L High Flow Pump, Arthro FMS 4, and Acufex InteliJet [26].
• METHODS: Five knots were evaluated (Weston, Tennessee, Duncan, SMC, and the new San Diego knot) using 2 suture materials, No. 2 Ethibond (Ethicon, Somerville, NJ) or No. 2 Fiberwire (Arthrex, Naples, FL) [27].

Analytical, diagnostic and therapeutic context of Arthrex

• The overall impression from clinical trials to date is that proquazone at dosages of greater than or equal to 900 mg/day produces a high incidence of gastrointestinal symptoms such as diarrhoea (in approximately 30% of patients) [1].
• Preliminary studies have confirmed the efficacy of proquazone in acute inflammatory disorders, and shown that it provides useful analgesic relief in acute pain states such as dysmenorrhoea, headache and after minor surgery [1].
• A method for the determination of proquazone and its m-hydroxy metabolite in serum and urine by reversed-phase high-performance liquid chromatography is described [6].
• Each dosage level of proquazone and aspirin provided significant analgesia compared to placebo and was well tolerated [16].
• METHODS: A 15-mm medial opening gap was stabilized in each of eight medium composite tibial bones either with the modified Arthrex Osteotomy Plate (Puddu Plate) or the TomoFix Plate [28].

References