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Chemical Compound Review

Modecate     2-[4-[3-[2-(trifluoromethyl) phenothiazin...

Synonyms: Moditen-depo, Dapotum D, SureCN41288, Moditen depot, CCRIS 3954, ...
 
 
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Disease relevance of Lyogen

 

Psychiatry related information on Lyogen

 

High impact information on Lyogen

 

Chemical compound and disease context of Lyogen

 

Biological context of Lyogen

 

Anatomical context of Lyogen

  • Treatment with a single weekly dose of fluphenazine decanoate (5 mg/kg) for 3 weeks resulted in increased HVA levels in all the above brain regions, cisternal cerebrospinal fluid and plasma [23].
  • This response was not seen following administration of NT into other striatal regions or the substantia nigra and was suppressed by the NT antagonist SR 48692 (100 micrograms/kg i.p.). Vacuous chewing movements were also seen following chronic administration of fluphenazine decanoate [24].
  • The roles of depot injection sites and proximal lymph nodes in the presystemic absorption of fluphenazine decanoate and fluphenazine: ex vivo experiments in rats [25].
  • These patients, treated with high total doses of different oral neuroleptics and fluphenazine depot, showed some EEG and ECG abnormalities, eye changes, slight leucopenia, a low number of staff nuclei neutrophils and infiltrations at the injection site, but these reactions did not result in any practical handicaps [26].
 

Associations of Lyogen with other chemical compounds

 

Gene context of Lyogen

 

Analytical, diagnostic and therapeutic context of Lyogen

References

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  13. Daytime variation in serum prolactin level in patients receiving oral and depot antipsychotic medication. Goode, D.J., Meltzer, H.Y., Fang, V.S. Biol. Psychiatry (1981) [Pubmed]
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  21. Systemic relaxin in pregnant pony mares grazed on endophyte-infected fescue: effects of fluphenazine treatment. Ryan, P.L., Bennett-Wimbush, K., Vaala, W.E., Bagnell, C.A. Theriogenology (2001) [Pubmed]
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  28. A long term comparative trial of penfluridol and fluphenazine decanoate in schizophrenic outpatients. Iqbal, M.J., Young, M.A., Charles, J., Elgart, B., Von Greiff, H., Simpson, G.M. The Journal of clinical psychiatry. (1978) [Pubmed]
  29. Comparative study of the pharmacokinetics of zuclopenthixol decanoate and fluphenazine decanoate. Viala, A., Ba, B., Durand, A., Gouezo, F., Hou, N., Jørgensen, A. Psychopharmacology (Berl.) (1988) [Pubmed]
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