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Chemical Compound Review

Plaquenil     2-[4-[(7-chloroquinolin-4- yl)amino]pentyl...

Synonyms: Ercoquin, Quensyl, Polirreumin, Oxychlorochin, Oxichloroquine, ...
 
 
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Analytical, diagnostic and therapeutic context of Plaquenil

References

  1. Penicillamine and hydroxychloroquine in the treatment of severe juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind placebo-controlled trial. Brewer, E.J., Giannini, E.H., Kuzmina, N., Alekseev, L. N. Engl. J. Med. (1986) [Pubmed]
  2. Hydroxychloroquine-induced vertigo. Prince, D.S., Hardin, J.G. JAMA (1975) [Pubmed]
  3. Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases. Klinger, G., Morad, Y., Westall, C.A., Laskin, C., Spitzer, K.A., Koren, G., Ito, S., Buncic, R.J. Lancet (2001) [Pubmed]
  4. Systemic lupus erythematosus presenting as panniculitis (lupus profundus). Díaz-Jouanen, E., DeHoratius, R.J., Alarcón-Segovia, D., Messner, R.P. Ann. Intern. Med. (1975) [Pubmed]
  5. Systemic lupus erythematosus: emerging concepts. Part 2: Dermatologic and joint disease, the antiphospholipid antibody syndrome, pregnancy and hormonal therapy, morbidity and mortality, and pathogenesis. Boumpas, D.T., Fessler, B.J., Austin, H.A., Balow, J.E., Klippel, J.H., Lockshin, M.D. Ann. Intern. Med. (1995) [Pubmed]
  6. Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort. Pons-Estel, G.J., Alarcón, G.S., McGwin, G., Danila, M.I., Zhang, J., Bastian, H.M., Reveille, J.D., Vilá, L.M. Arthritis Rheum. (2009) [Pubmed]
  7. Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study. Van Gool, W.A., Weinstein, H.C., Scheltens, P., Walstra, G.J., Scheltens, P.K. Lancet (2001) [Pubmed]
  8. Hydroxychloroquine and pain thresholds. Middleton, G.D., McFarlin, J.E., Lipsky, P.E. Arthritis Rheum. (1995) [Pubmed]
  9. Ocular adverse effects associated with systemic medications : recognition and management. Santaella, R.M., Fraunfelder, F.W. Drugs (2007) [Pubmed]
  10. Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications. O'Dell, J.R., Haire, C.E., Erikson, N., Drymalski, W., Palmer, W., Eckhoff, P.J., Garwood, V., Maloley, P., Klassen, L.W., Wees, S., Klein, H., Moore, G.F. N. Engl. J. Med. (1996) [Pubmed]
  11. Hydroxychloroquine in systemic lupus erythematosus. Disla, E., Brar, H., Taranta, A. N. Engl. J. Med. (1991) [Pubmed]
  12. Hydroxychloroquine in decompensated, treatment-refractory noninsulin-dependent diabetes mellitus. A new job for an old drug? Quatraro, A., Consoli, G., Magno, M., Caretta, F., Nardozza, A., Ceriello, A., Giugliano, D. Ann. Intern. Med. (1990) [Pubmed]
  13. Animal toxicity and pharmacokinetics of hydroxychloroquine sulfate. McChesney, E.W. Am. J. Med. (1983) [Pubmed]
  14. Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine. Raoult, D., Houpikian, P., Tissot Dupont, H., Riss, J.M., Arditi-Djiane, J., Brouqui, P. Arch. Intern. Med. (1999) [Pubmed]
  15. Cholesterol-lowering effect of hydroxychloroquine in patients with rheumatic disease: reversal of deleterious effects of steroids on lipids. Wallace, D.J., Metzger, A.L., Stecher, V.J., Turnbull, B.A., Kern, P.A. Am. J. Med. (1990) [Pubmed]
  16. Hydroxychloroquine treatment of hypercalcemia in a patient with sarcoidosis undergoing hemodialysis. Barré, P.E., Gascon-Barré, M., Meakins, J.L., Goltzman, D. Am. J. Med. (1987) [Pubmed]
  17. Etanercept treatment of cutaneous granulomas in common variable immunodeficiency. Lin, J.H., Liebhaber, M., Roberts, R.L., Dyer, Z., Stiehm, E.R. J. Allergy Clin. Immunol. (2006) [Pubmed]
  18. Induction of apoptosis in peripheral blood lymphocytes following treatment in vitro with hydroxychloroquine. Meng, X.W., Feller, J.M., Ziegler, J.B., Pittman, S.M., Ireland, C.M. Arthritis Rheum. (1997) [Pubmed]
  19. New American Academy of Ophthalmology recommendations on screening for hydroxychloroquine retinopathy. Marmor, M.F. Arthritis Rheum. (2003) [Pubmed]
  20. Electroretinograms of children born to mothers treated with hydroxychloroquine during pregnancy and breast-feeding: comment on the article by Costedoat-Chalumeau et al. Cimaz, R., Brucato, A., Meregalli, E., Muscará, M., Sergi, P. Arthritis Rheum. (2004) [Pubmed]
  21. Western and Chinese antirheumatic drug-induced T cell apoptotic DNA damage uses different caspase cascades and is independent of Fas/Fas ligand interaction. Lai, J.H., Ho, L.J., Lu, K.C., Chang, D.M., Shaio, M.F., Han, S.H. J. Immunol. (2001) [Pubmed]
  22. Pharmacologic actions of 4-aminoquinoline compounds. Mackenzie, A.H. Am. J. Med. (1983) [Pubmed]
  23. Hydroxychloroquine inhibits calcium signals in T cells: a new mechanism to explain its immunomodulatory properties. Goldman, F.D., Gilman, A.L., Hollenback, C., Kato, R.M., Premack, B.A., Rawlings, D.J. Blood (2000) [Pubmed]
  24. Safety of hydroxychloroquine in pregnant patients with connective tissue diseases: a study of one hundred thirty-three cases compared with a control group. Costedoat-Chalumeau, N., Amoura, Z., Duhaut, P., Huong, d.u. .L.T., Sebbough, D., Wechsler, B., Vauthier, D., Denjoy, I., Lupoglazoff, J.M., Piette, J.C. Arthritis Rheum. (2003) [Pubmed]
  25. Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine. Boya, P., Gonzalez-Polo, R.A., Poncet, D., Andreau, K., Vieira, H.L., Roumier, T., Perfettini, J.L., Kroemer, G. Oncogene (2003) [Pubmed]
  26. Granulomatous infiltration of the talus and abnormal vitamin D and calcium metabolism in a patient with sarcoidosis: successful treatment with hydroxychloroquine. DeSimone, D.P., Brilliant, H.L., Basile, J., Bell, N.H. Am. J. Med. (1989) [Pubmed]
  27. Treatment of intractable rheumatoid arthritis with combined cyclophosphamide, azathioprine, and hydroxychloroquine. A follow-up study. Csuka, M., Carrera, G.F., McCarty, D.J. JAMA (1986) [Pubmed]
  28. Intractable rheumatoid arthritis. Treatment with combined cyclophosphamide, azathioprine, and hydroxychloroquine. McCarty, D.J., Carrera, G.F. JAMA (1982) [Pubmed]
  29. Effects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis. van der Heijde, D.M., van Riel, P.L., Nuver-Zwart, I.H., Gribnau, F.W., vad de Putte, L.B. Lancet (1989) [Pubmed]
  30. Controlled trial of hydroxychloroquine and D-penicillamine singly and in combination in the treatment of rheumatoid arthritis. Bunch, T.W., O'Duffy, J.D., Tompkins, R.B., O'Fallon, W.M. Arthritis Rheum. (1984) [Pubmed]
  31. Treatment of early seropositive rheumatoid arthritis: a two-year, double-blind comparison of minocycline and hydroxychloroquine. O'Dell, J.R., Blakely, K.W., Mallek, J.A., Eckhoff, P.J., Leff, R.D., Wees, S.J., Sems, K.M., Fernandez, A.M., Palmer, W.R., Klassen, L.W., Paulsen, G.A., Haire, C.E., Moore, G.F. Arthritis Rheum. (2001) [Pubmed]
  32. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Blackburn, W.D., Prupas, H.M., Silverfield, J.C., Poiley, J.E., Caldwell, J.R., Collins, R.L., Miller, M.J., Sikes, D.H., Kaplan, H., Fleischmann, R. Arthritis Rheum. (1995) [Pubmed]
  33. Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model. Martirosyan, A.R., Rahim-Bata, R., Freeman, A.B., Clarke, C.D., Howard, R.L., Strobl, J.S. Biochem. Pharmacol. (2004) [Pubmed]
  34. Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL-1-alpha) and IL-6 in human monocytes and T cells. Sperber, K., Quraishi, H., Kalb, T.H., Panja, A., Stecher, V., Mayer, L. J. Rheumatol. (1993) [Pubmed]
  35. Chloroquine decreases cell-surface expression of tumour necrosis factor receptors in human histiocytic U-937 cells. Jeong, J.Y., Choi, J.W., Jeon, K.I., Jue, D.M. Immunology (2002) [Pubmed]
  36. Circulating levels of interleukin 10 and other cytokines in rheumatoid arthritis treated with cyclosporin A or combination therapy. Ferraccioli, G., Falleti, E., De Vita, S., Di Poi, E., Damato, R., Casatta, L., Salaffi, F. J. Rheumatol. (1998) [Pubmed]
  37. Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in mice. Edwards, M.H., Pierangeli, S., Liu, X., Barker, J.H., Anderson, G., Harris, E.N. Circulation (1997) [Pubmed]
  38. Plasma hydroxychloroquine concentrations and efficacy in rheumatoid arthritis. Miller, D.R., Fiechtner, J.J., Carpenter, J.R., Brown, R.R., Stroshane, R.M., Stecher, V.J. Arthritis Rheum. (1987) [Pubmed]
  39. The relative toxicity of disease-modifying antirheumatic drugs. Fries, J.F., Williams, C.A., Ramey, D., Bloch, D.A. Arthritis Rheum. (1993) [Pubmed]
  40. Hydroxychloroquine and postoperative thromboembolism after total hip replacement. Loudon, J.R. Am. J. Med. (1988) [Pubmed]
 
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