Chemical Compound Review:
Tnp-470 [(3S,4S,5S,6R)-5-methoxy-4- [(2R,3R)-2...
Synonyms:
CHEMBL424278, AGM-1470, CHEBI:47708, NSC-642492, DNC001374, ...
- Inhibition of angiogenesis in vivo by interleukin 12. Voest, E.E., Kenyon, B.M., O'Reilly, M.S., Truitt, G., D'Amato, R.J., Folkman, J. J. Natl. Cancer Inst. (1995)
- Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470; AGM-1470). Yamaoka, M., Yamamoto, T., Masaki, T., Ikeyama, S., Sudo, K., Fujita, T. Cancer Res. (1993)
- A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells. Abe, J., Zhou, W., Takuwa, N., Taguchi, J., Kurokawa, K., Kumada, M., Takuwa, Y. Cancer Res. (1994)
- Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma. Inoue, K., Chikazawa, M., Fukata, S., Yoshikawa, C., Shuin, T. Clin. Cancer Res. (2003)
- The angiogenesis inhibitor tnp-470 effectively inhibits human neuroblastoma xenograft growth, especially in the setting of subclinical disease. Shusterman, S., Grupp, S.A., Barr, R., Carpentieri, D., Zhao, H., Maris, J.M. Clin. Cancer Res. (2001)
- Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470. Klauber, N., Rohan, R.M., Flynn, E., D'Amato, R.J. Nat. Med. (1997)
- Simulation of human B-lymphocyte proliferation by AGM-1470, a potent inhibitor of angiogenesis. Antoine, N., Bours, V., Heinen, E., Simar, L.J., Castronovo, V. J. Natl. Cancer Inst. (1995)
- The role of angiogenesis in the tumor growth of Syrian hamster pancreatic cancer cell line HPD-NR. Egawa, S., Tsutsumi, M., Konishi, Y., Kobari, M., Matsuno, S., Nagasaki, K., Futami, H., Yamaguchi, K. Gastroenterology (1995)
- Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1. Zhang, Y., Griffith, E.C., Sage, J., Jacks, T., Liu, J.O. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Efficacy of CDDP and AGM-1470 chemotherapy against lung metastasis in rat osteosarcoma depends on the timing of combined administration. Morishita, T., Mii, Y., Miyauchi, Y., Miura, S., Honoki, K., Aoki, M., Kido, A., Tamai, S., Tsutsumi, M., Konishi, Y. Jpn. J. Clin. Oncol. (1997)
- AGM-1470, a potent angiogenesis inhibitor, prevents the entry of normal but not transformed endothelial cells into the G1 phase of the cell cycle. Antoine, N., Greimers, R., De Roanne, C., Kusaka, M., Heinen, E., Simar, L.J., Castronovo, V. Cancer Res. (1994)
- Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes. Placidi, L., Cretton-Scott, E., de Sousa, G., Rahmani, R., Placidi, M., Sommadossi, J.P. Cancer Res. (1995)
- The influence of angiogenesis inhibitor AGM-1470 on immune system status and tumor growth in vitro. Schoof, D.D., Obando, J.A., Cusack, J.C., Goedegebuure, P.S., Brem, H., Eberlein, T.J. Int. J. Cancer (1993)
- Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines. Yamaoka, M., Yamamoto, T., Ikeyama, S., Sudo, K., Fujita, T. Cancer Res. (1993)
- In vitro and in vivo stimulation of the murine immune system by AGM-1470, a potent angiogenesis inhibitor. Antoine, N., Daukandt, M., Heinen, E., Simar, L.J., Castronovo, V. Am. J. Pathol. (1996)
- Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models. Schirner, M., Hoffmann, J., Menrad, A., Schneider, M.R. Clin. Cancer Res. (1998)
- Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Griffith, E.C., Su, Z., Turk, B.E., Chen, S., Chang, Y.H., Wu, Z., Biemann, K., Liu, J.O. Chem. Biol. (1997)
- Suppression of collagen-induced arthritis by an angiogenesis inhibitor, AGM-1470, in combination with cyclosporin: reduction of vascular endothelial growth factor (VEGF). Oliver, S.J., Cheng, T.P., Banquerigo, M.L., Brahn, E. Cell. Immunol. (1995)
- The potent angioinhibin AGM-1470 stimulates normal but not human tumoral lymphocytes. Antoine, N., Daukandt, M., Locigno, R., Heinen, E., Simar, L.J., Castronovo, V. Tumori. (1996)
- Suppression of arthritis and protection from bone destruction by treatment with TNP-470/AGM-1470 in a transgenic mouse model of rheumatoid arthritis. de Bandt, M., Grossin, M., Weber, A.J., Chopin, M., Elbim, C., Pla, M., Gougerot-Pocidalo, M.A., Gaudry, M. Arthritis Rheum. (2000)
- Selective inhibition of protein kinase C, mitogen-activated protein kinase, and neutrophil activation in response to calcium pyrophosphate dihydrate crystals, formyl-methionyl-leucyl-phenylalanine, and phorbol ester by O-(chloroacetyl-carbamoyl) fumagillol (AGM-1470; TNP-470). Tudan, C., Jackson, J.K., Pelech, S.L., Attardo, G., Burt, H. Biochem. Pharmacol. (1999)
- Angiogenesis inhibition suppresses collagen arthritis. Peacock, D.J., Banquerigo, M.L., Brahn, E. J. Exp. Med. (1992)
- Increased growth and incidence of lymph node metastases due to the angiogenesis inhibitor AGM-1470. Hori, K., Li, H.C., Saito, S., Sato, Y. Br. J. Cancer (1997)
- Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent. Kusaka, M., Sudo, K., Fujita, T., Marui, S., Itoh, F., Ingber, D., Folkman, J. Biochem. Biophys. Res. Commun. (1991)