Chemical Compound Review:
Lonidamin 1-[(2,4-dichlorophenyl) methyl]indazole-3...
Synonyms:
Doridamina, Lonidamina, lonidamine, Lonidaminum, DICA, ...
Comella,
Frasci,
Panza,
Manzione,
Lorusso,
Di Rienzo,
Cioffi,
De Cataldis,
Maiorino,
Bilancia,
Nicolella,
Natale,
Carpagnano,
Pacilio,
De Lena,
Bianco,
Comella,
Ono,
Iwanaga,
Hirayama,
Kawamura,
Sowa,
Hasegawa,
Papaldo,
Lopez,
Cortesi,
Cammilluzzi,
Antimi,
Terzoli,
Lepidini,
Vici,
Barone,
Ferretti,
Di Cosimo,
Nistico,
Carlini,
Conti,
Di Lauro,
Botti,
Vitucci,
Fabi,
Giannarelli,
Marolla,
- Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment. Miccoli, L., Poirson-Bichat, F., Sureau, F., Bras Gonçalves, R., Bourgeois, Y., Dutrillaux, B., Poupon, M.F., Oudard, S. J. Natl. Cancer Inst. (1998)
- Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells. Ramos, A.M., Fernández, C., Amrán, D., Sancho, P., de Blas, E., Aller, P. Blood (2005)
- Phase I trial of lonidamine with whole body hyperthermia in advanced cancer. Robins, H.I., Longo, W.L., Lagoni, R.K., Neville, A.J., Hugander, A., Schmitt, C.L., Riggs, C. Cancer Res. (1988)
- Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide. Papaldo, P., Lopez, M., Cortesi, E., Cammilluzzi, E., Antimi, M., Terzoli, E., Lepidini, G., Vici, P., Barone, C., Ferretti, G., Di Cosimo, S., Nistico, C., Carlini, P., Conti, F., Di Lauro, L., Botti, C., Vitucci, C., Fabi, A., Giannarelli, D., Marolla, P. J. Clin. Oncol. (2003)
- Chemosensitization by knockdown of adenine nucleotide translocase-2. Le Bras, M., Borgne-Sanchez, A., Touat, Z., El Dein, O.S., Deniaud, A., Maillier, E., Lecellier, G., Rebouillat, D., Lemaire, C., Kroemer, G., Jacotot, E., Brenner, C. Cancer Res. (2006)
- Mitochondrion as a novel target of anticancer chemotherapy. Costantini, P., Jacotot, E., Decaudin, D., Kroemer, G. J. Natl. Cancer Inst. (2000)
- Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene. Del Bufalo, D., Biroccio, A., Soddu, S., Laudonio, N., D'Angelo, C., Sacchi, A., Zupi, G. J. Clin. Invest. (1996)
- Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: final results of a phase III study with a factorial design. Berruti, A., Bitossi, R., Gorzegno, G., Bottini, A., Alquati, P., De Matteis, A., Nuzzo, F., Giardina, G., Danese, S., De Lena, M., Lorusso, V., Farris, A., Sarobba, M.G., DeFabiani, E., Bonazzi, G., Castiglione, F., Bumma, C., Moro, G., Bruzzi, P., Dogliotti, L. J. Clin. Oncol. (2002)
- Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells. Floridi, A., Paggi, M.G., D'Atri, S., De Martino, C., Marcante, M.L., Silvestrini, B., Caputo, A. Cancer Res. (1981)
- Lonidamine as a modulator of alkylating agent activity in vitro and in vivo. Teicher, B.A., Herman, T.S., Holden, S.A., Epelbaum, R., Liu, S.D., Frei, E. Cancer Res. (1991)
- Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells. Floridi, A., Paggi, M.G., Marcante, M.L., Silvestrini, B., Caputo, A., De Martino, C. J. Natl. Cancer Inst. (1981)
- Potentiation of radiation effects on two murine tumors by lonidamine. Kim, J.H., Alfieri, A.A., Kim, S.H., Young, C.W. Cancer Res. (1986)
- Testin is tightly associated with testicular cell membrane upon its secretion by sertoli cells whose steady-state mRNA level in the testis correlates with the turnover and integrity of inter-testicular cell junctions. Grima, J., Zhu, L., Cheng, C.Y. J. Biol. Chem. (1997)
- Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore. Ravagnan, L., Marzo, I., Costantini, P., Susin, S.A., Zamzami, N., Petit, P.X., Hirsch, F., Goulbern, M., Poupon, M.F., Miccoli, L., Xie, Z., Reed, J.C., Kroemer, G. Oncogene (1999)
- Cisplatin, gemcitabine, and vinorelbine combination therapy in advanced non-small-cell lung cancer: a phase II randomized study of the Southern Italy Cooperative Oncology Group. Comella, P., Frasci, G., Panza, N., Manzione, L., Lorusso, V., Di Rienzo, G., Cioffi, R., De Cataldis, G., Maiorino, L., Bilancia, D., Nicolella, G., Natale, M., Carpagnano, F., Pacilio, C., De Lena, M., Bianco, A., Comella, G. J. Clin. Oncol. (1999)
- The H+-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma. Fang, J., Quinones, Q.J., Holman, T.L., Morowitz, M.J., Wang, Q., Zhao, H., Sivo, F., Maris, J.M., Wahl, M.L. Mol. Pharmacol. (2006)
- Enhancement of cisplatin activity by lonidamine in human ovarian cancer cells. Silvestrini, R., Zaffaroni, N., Villa, R., Orlandi, L., Costa, A. Int. J. Cancer (1992)
- Etoposide with lonidamine or pentoxifylline as modulators of alkylating agent activity in vivo. Tanaka, J., Teicher, B.A., Herman, T.S., Holden, S.A., Dezube, B., Frei, E. Int. J. Cancer (1991)
- Contribution of caveolin-1 alpha and Akt to TNF-alpha-induced cell death. Ono, K., Iwanaga, Y., Hirayama, M., Kawamura, T., Sowa, N., Hasegawa, K. Am. J. Physiol. Lung Cell Mol. Physiol. (2004)
- Lonidamine as a modulator of taxol activity in human ovarian cancer cells: effects on cell cycle and induction of apoptosis. Orlandi, L., Zaffaroni, N., Bearzatto, A., Villa, R., De Marco, C., Silvestrini, R. Int. J. Cancer (1998)
- Morphological changes in the hearts of CD1 mice following chronic treatment with doxorubicin and lonidamine. Sanguedolce, R., Flandina, C., Cucchiara, T., Varvara, F., Rausa, L. Res. Commun. Chem. Pathol. Pharmacol. (1993)
- Mechanism of lonidamine inhibition of the CFTR chloride channel. Gong, X., Burbridge, S.M., Lewis, A.C., Wong, P.Y., Linsdell, P. Br. J. Pharmacol. (2002)
- Combination therapy: lonidamine, hyperthermia, and chemotherapy against the RIF-1 tumor in vivo. Ning, S.C., Hahn, G.M. Cancer Res. (1991)
- Mitochondrial permeability transition-pore inhibition enhances functional recovery after long-time hypothermic heart preservation. Rajesh, K.G., Sasaguri, S., Ryoko, S., Maeda, H. Transplantation (2003)
- Double-blind randomized study of lonidamine and radiotherapy in head and neck cancer. Magno, L., Terraneo, F., Bertoni, F., Tordiglione, M., Bardelli, D., Rosignoli, M.T., Ciottoli, G.B. Int. J. Radiat. Oncol. Biol. Phys. (1994)
- Toxicity and clinical tolerance of lonidamine. Robustelli della Cuna, G., Pedrazzoli, P. Semin. Oncol. (1991)