Chemical Compound Review:
cc-58 2-morpholin-4-yl-8-phenyl- chromen-4-one
Synonyms:
PubChem16766, SureCN94377, AG-E-02402, CHEBI:65329, CS-0150, ...
- Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Zhu, W.Z., Zheng, M., Koch, W.J., Lefkowitz, R.J., Kobilka, B.K., Xiao, R.P. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells. Chen, C.N., Li, Y.S., Yeh, Y.T., Lee, P.L., Usami, S., Chien, S., Chiu, J.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- A role for adrenomedullin as a pain-related peptide in the rat. Ma, W., Chabot, J.G., Quirion, R. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Angiotensin II activates phosphatidylinositol 3-kinase in vascular smooth muscle cells. Saward, L., Zahradka, P. Circ. Res. (1997)
- Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Hu, L., Hofmann, J., Lu, Y., Mills, G.B., Jaffe, R.B. Cancer Res. (2002)
- Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells. Kaliman, P., Viñals, F., Testar, X., Palacín, M., Zorzano, A. J. Biol. Chem. (1996)
- Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Aoki, K., Tamai, Y., Horiike, S., Oshima, M., Taketo, M.M. Nat. Genet. (2003)
- Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Yao, R., Cooper, G.M. Science (1995)
- Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Jiang, K., Zhong, B., Gilvary, D.L., Corliss, B.C., Hong-Geller, E., Wei, S., Djeu, J.Y. Nat. Immunol. (2000)
- Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Goswami, A., Burikhanov, R., de Thonel, A., Fujita, N., Goswami, M., Zhao, Y., Eriksson, J.E., Tsuruo, T., Rangnekar, V.M. Mol. Cell (2005)
- Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Chung, C.Y., Potikyan, G., Firtel, R.A. Mol. Cell (2001)
- Signal transduction pathways involved in soluble fractalkine-induced monocytic cell adhesion. Cambien, B., Pomeranz, M., Schmid-Antomarchi, H., Millet, M.A., Breittmayer, V., Rossi, B., Schmid-Alliana, A. Blood (2001)
- Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Fan, Q.W., Specht, K.M., Zhang, C., Goldenberg, D.D., Shokat, K.M., Weiss, W.A. Cancer Res. (2003)
- Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis. Cronshaw, D.G., Owen, C., Brown, Z., Ward, S.G. J. Immunol. (2004)
- Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells. Thiel, A., Heinonen, M., Rintahaka, J., Hallikainen, T., Hemmes, A., Dixon, D.A., Haglund, C., Ristimäki, A. J. Biol. Chem. (2006)
- The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1. Abdul-Ghani, R., Serra, V., Györffy, B., Jürchott, K., Solf, A., Dietel, M., Schäfer, R. Oncogene (2006)
- Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Walker, E.H., Pacold, M.E., Perisic, O., Stephens, L., Hawkins, P.T., Wymann, M.P., Williams, R.L. Mol. Cell (2000)
- Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation. Liu, H., Perlman, H., Pagliari, L.J., Pope, R.M. J. Exp. Med. (2001)
- Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. Rui, L., Aguirre, V., Kim, J.K., Shulman, G.I., Lee, A., Corbould, A., Dunaif, A., White, M.F. J. Clin. Invest. (2001)
- Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Andrew, N., Insall, R.H. Nat. Cell Biol. (2007)
- Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase. Brunskill, N.J., Stuart, J., Tobin, A.B., Walls, J., Nahorski, S. J. Clin. Invest. (1998)
- 1alpha,25-dihydroxyvitamin D(3)-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complex. Hmama, Z., Nandan, D., Sly, L., Knutson, K.L., Herrera-Velit, P., Reiner, N.E. J. Exp. Med. (1999)
- Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. Palframan, R.T., Collins, P.D., Severs, N.J., Rothery, S., Williams, T.J., Rankin, S.M. J. Exp. Med. (1998)
- Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning. Carini, R., Grazia De Cesaris, M., Splendore, R., Baldanzi, G., Nitti, M.P., Alchera, E., Filigheddu, N., Domenicotti, C., Pronzato, M.A., Graziani, A., Albano, E. Gastroenterology (2004)
- Regulatory role of phosphatidylinositol 3-kinase on TNF-alpha-induced cyclooxygenase 2 expression in colonic epithelial cells. Weaver, S.A., Russo, M.P., Wright, K.L., Kolios, G., Jobin, C., Robertson, D.A., Ward, S.G. Gastroenterology (2001)
- Increased expression and function of integrins in enterocytes by endotoxin impairs epithelial restitution. Qureshi, F.G., Leaphart, C., Cetin, S., Li, J., Grishin, A., Watkins, S., Ford, H.R., Hackam, D.J. Gastroenterology (2005)
- A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. Bony, C., Roche, S., Shuichi, U., Sasaki, T., Crackower, M.A., Penninger, J., Mano, H., Pucéat, M. J. Cell Biol. (2001)
- Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells. Brown, W.J., DeWald, D.B., Emr, S.D., Plutner, H., Balch, W.E. J. Cell Biol. (1995)
- Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Chalecka-Franaszek, E., Chuang, D.M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles. Misra, S., Ujházy, P., Varticovski, L., Arias, I.M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis. Niemann, C., Brinkmann, V., Spitzer, E., Hartmann, G., Sachs, M., Naundorf, H., Birchmeier, W. J. Cell Biol. (1998)
- Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. Fujita, T., Azuma, Y., Fukuyama, R., Hattori, Y., Yoshida, C., Koida, M., Ogita, K., Komori, T. J. Cell Biol. (2004)
- PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Li, D.M., Sun, H. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. Takaishi, H., Konishi, H., Matsuzaki, H., Ono, Y., Shirai, Y., Saito, N., Kitamura, T., Ogawa, W., Kasuga, M., Kikkawa, U., Nishizuka, Y. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Jiang, B.H., Zheng, J.Z., Aoki, M., Vogt, P.K. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Reversal of the Ras-induced transformed phenotype by HR12, a novel ras farnesylation inhibitor, is mediated by the Mek/Erk pathway. Reuveni, H., Geiger, T., Geiger, B., Levitzki, A. J. Cell Biol. (2000)
- Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase. Taguchi, Y., Kondo, T., Watanabe, M., Miyaji, M., Umehara, H., Kozutsumi, Y., Okazaki, T. Blood (2004)
- Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis. Chen, J.K., Capdevila, J., Harris, R.C. Mol. Cell. Biol. (2001)
- The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy. Sourbier, C., Lindner, V., Lang, H., Agouni, A., Schordan, E., Danilin, S., Rothhut, S., Jacqmin, D., Helwig, J.J., Massfelder, T. Cancer Res. (2006)
- The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Lin, J., Adam, R.M., Santiestevan, E., Freeman, M.R. Cancer Res. (1999)