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Chemical Compound Review

AC1N9ZJI     (3S,7R)-3,7-dimethyl-9- (2,6,6-trimethyl-1...

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Disease relevance of Retinoic acid


Psychiatry related information on Retinoic acid


High impact information on Retinoic acid

  • Finally, retinoic acid receptors regulate many developmental control genes, including homeobox genes and growth factor genes [11].
  • The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling [12].
  • The two factors compete for binding to the miR-223 promoter: NFI-A maintains miR-223 at low levels, whereas its replacement by C/EBPalpha, following retinoic acid (RA)-induced differentiation, upregulates miR-223 expression [13].
  • Retinoic acid (RA) induces proliferation arrest, differentiation, and apoptosis, and defects in retinoic acid receptor (RAR) signaling have been implicated in cancer [12].
  • Cyp26a1(-/-) mouse fetuses have lethal morphogenetic phenotypes mimicking those generated by excess retinoic acid administration, indicating that human CYP26A1 may be essential in controlling retinoic acid levels during development [14].

Chemical compound and disease context of Retinoic acid


Biological context of Retinoic acid


Anatomical context of Retinoic acid


Associations of Retinoic acid with other chemical compounds


Gene context of Retinoic acid


Analytical, diagnostic and therapeutic context of Retinoic acid


  1. Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentiation. Dinsmore, J.H., Solomon, F. Cell (1991) [Pubmed]
  2. Developmental activation of the H-2K gene is correlated with an increase in DNA methylation. Tanaka, K., Appella, E., Jay, G. Cell (1983) [Pubmed]
  3. Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin. Kraemer, K.H., DiGiovanna, J.J., Moshell, A.N., Tarone, R.E., Peck, G.L. N. Engl. J. Med. (1988) [Pubmed]
  4. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Nagy, L., Kao, H.Y., Chakravarti, D., Lin, R.J., Hassig, C.A., Ayer, D.E., Schreiber, S.L., Evans, R.M. Cell (1997) [Pubmed]
  5. Plasminogen activator in chick embryo muscle cells: induction of enzyme by RSV, PMA and retinoic acid. Miskin, R., Easton, T.G., Reich, E. Cell (1978) [Pubmed]
  6. Survival motor neuron (SMN) protein: role in neurite outgrowth and neuromuscular maturation during neuronal differentiation and development. Fan, L., Simard, L.R. Hum. Mol. Genet. (2002) [Pubmed]
  7. Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain. Luthi-Carter, R., Hanson, S.A., Strand, A.D., Bergstrom, D.A., Chun, W., Peters, N.L., Woods, A.M., Chan, E.Y., Kooperberg, C., Krainc, D., Young, A.B., Tapscott, S.J., Olson, J.M. Hum. Mol. Genet. (2002) [Pubmed]
  8. Retinoids modulate endothelial cell production of matrix-degrading proteases and tissue inhibitors of metalloproteinases (TIMP). Braunhut, S.J., Moses, M.A. J. Biol. Chem. (1994) [Pubmed]
  9. Altered activation by calcitonin and inhibition by somatostatin of human embryonal carcinoma cell adenylate cyclase with retinoic acid-induced differentiation. Liapi, C., Anderson, W.B., Evain-Brion, D. Dev. Biol. (1986) [Pubmed]
  10. Topical retinoic acid enhances, and a dark tan protects, from subedemal solar-simulated photocarcinogenesis. Halliday, G.M., Robertson, B.O., Barnetson, R.S. J. Invest. Dermatol. (2000) [Pubmed]
  11. The roles of retinoids in vertebrate development. Means, A.L., Gudas, L.J. Annu. Rev. Biochem. (1995) [Pubmed]
  12. The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. Epping, M.T., Wang, L., Edel, M.J., Carlée, L., Hernandez, M., Bernards, R. Cell (2005) [Pubmed]
  13. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Fazi, F., Rosa, A., Fatica, A., Gelmetti, V., De Marchis, M.L., Nervi, C., Bozzoni, I. Cell (2005) [Pubmed]
  14. Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Niederreither, K., Abu-Abed, S., Schuhbaur, B., Petkovich, M., Chambon, P., Dollé, P. Nat. Genet. (2002) [Pubmed]
  15. Topical tretinoin (retinoic acid) therapy for hyperpigmented lesions caused by inflammation of the skin in black patients. Bulengo-Ransby, S.M., Griffiths, C.E., Kimbrough-Green, C.K., Finkel, L.J., Hamilton, T.A., Ellis, C.N., Voorhees, J.J. N. Engl. J. Med. (1993) [Pubmed]
  16. Possible role of retinoic acid binding protein in retinoid stimulation of embryonal carcinoma cell differentiation. Jetten, A.M., Jetten, M.E. Nature (1979) [Pubmed]
  17. Nerve growth factor induces adrenergic neuronal differentiation in F9 teratocarcinoma cells. Liesi, P., Rechardt, L., Wartiovaara, J. Nature (1983) [Pubmed]
  18. HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: lovastatin specifically targets P-glycoprotein-expressing cells. Dimitroulakos, J., Yeger, H. Nat. Med. (1996) [Pubmed]
  19. Multiple cell type-specific proteins differentially regulate target sequence recognition by the alpha retinoic acid receptor. Glass, C.K., Devary, O.V., Rosenfeld, M.G. Cell (1990) [Pubmed]
  20. Hormonal induction of differentiation in teratocarcinoma stem cells: generation of parietal endoderm by retinoic acid and dibutyryl cAMP. Strickland, S., Smith, K.K., Marotti, K.R. Cell (1980) [Pubmed]
  21. Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors. Nagpal, S., Saunders, M., Kastner, P., Durand, B., Nakshatri, H., Chambon, P. Cell (1992) [Pubmed]
  22. Cooperativity and hierarchical levels of functional organization in the SV40 enhancer. Fromental, C., Kanno, M., Nomiyama, H., Chambon, P. Cell (1988) [Pubmed]
  23. A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Chowdhury, K., Deutsch, U., Gruss, P. Cell (1987) [Pubmed]
  24. Plasminogen activator in chick fibroblasts: induction of synthesis by retinoic acid; synergism with viral transformation and phorbol ester. Wilson, E.L., Reich, E. Cell (1978) [Pubmed]
  25. The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Strickland, S., Mahdavi, V. Cell (1978) [Pubmed]
  26. Lipid composition and lateral diffusion in plasma membranes of teratocarcinoma-derived cell lines. Searls, D.B., Edidin, M. Cell (1981) [Pubmed]
  27. Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development. Nohno, T., Noji, S., Koyama, E., Ohyama, K., Myokai, F., Kuroiwa, A., Saito, T., Taniguchi, S. Cell (1991) [Pubmed]
  28. Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin. Lotan, R., Xu, X.C., Lippman, S.M., Ro, J.Y., Lee, J.S., Lee, J.J., Hong, W.K. N. Engl. J. Med. (1995) [Pubmed]
  29. Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer. Glass, C.K., Lipkin, S.M., Devary, O.V., Rosenfeld, M.G. Cell (1989) [Pubmed]
  30. The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Näär, A.M., Boutin, J.M., Lipkin, S.M., Yu, V.C., Holloway, J.M., Glass, C.K., Rosenfeld, M.G. Cell (1991) [Pubmed]
  31. v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action. Sharif, M., Privalsky, M.L. Cell (1991) [Pubmed]
  32. UV-induced extracellular factor from human fibroblasts communicates the UV response to nonirradiated cells. Schorpp, M., Mallick, U., Rahmsdorf, H.J., Herrlich, P. Cell (1984) [Pubmed]
  33. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Kakizuka, A., Miller, W.H., Umesono, K., Warrell, R.P., Frankel, S.R., Murty, V.V., Dmitrovsky, E., Evans, R.M. Cell (1991) [Pubmed]
  34. Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia. Wells, R.A., Catzavelos, C., Kamel-Reid, S. Nat. Genet. (1997) [Pubmed]
  35. Retinoic acid rescues inner ear defects in Hoxa1 deficient mice. Pasqualetti, M., Neun, R., Davenne, M., Rijli, F.M. Nat. Genet. (2001) [Pubmed]
  36. Differential formation of desmosomes and hemidesmosomes in epidermal cell cultures treated with retinoic acid. Christophers, E., Wolff, H.H. Nature (1975) [Pubmed]
  37. Retinoic acid normalizes the increased gene transcription rate of TGF-alpha and EGFR in head and neck cancer cell lines. Rubin Grandis, J., Zeng, Q., Tweardy, D.J. Nat. Med. (1996) [Pubmed]
  38. p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells. Kawasaki, H., Song, J., Eckner, R., Ugai, H., Chiu, R., Taira, K., Shi, Y., Jones, N., Yokoyama, K.K. Genes Dev. (1998) [Pubmed]
  39. Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Mark, M., Ghyselinck, N.B., Chambon, P. Annu. Rev. Pharmacol. Toxicol. (2006) [Pubmed]
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